Evaluation of intranasal delivery route of drug administration for brain targeting

[Display omitted] •The two main pathways of intranasal drug absorption are the olfactory and trigeminal routes.•The intranasal drugs can bypass the blood-brain barrier and blood-CSF barrier.•There are in vitro, ex vivo and in vivo models for testing drug penetration by intranasal route.•The drug pen...

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Bibliographic Details
Published in:	Brain research bulletin Vol. 143; pp. 155 - 170
Main Authors:	Erdő, Franciska, Bors, Luca Anna, Farkas, Dániel, Bajza, Ágnes, Gizurarson, Sveinbjörn
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.10.2018
Subjects:	CNS indication Delivery enhancer techniques Drug delivery Intranasal administration Transporter interactions IFN-β1b BBB EPO AUC ANG II RPMI 2650 l-DOPA V1 V2 V3 Delivery enhancer techniques AD P-gp FGF PACAP IN FST EN IGF-1 Intranasal administration NGF OEC LCC IL-6 TST CNS indication ADNP E ONF CNS Drug delivery SC IF γ MCP1 Transporter interactions CSF GA MSC MCAO GLP-1 CaCo-2 MOG SCA-1 VEGF OSN HIV PD scFv TJ TEER TGF-β1 PK HD ALI GALP
ISSN:	0361-9230, 1873-2747, 1873-2747
Online Access:	Get full text
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