Vision and Vision-Related Measures in Progressive Multiple Sclerosis
Over the last few years there has been growing interest in use of visual measures as useful tools for multiple sclerosis (MS) prognosis and tracking. Optic neuritis (ON) being a prevalent and often-presenting symptom of the disease, as well as the high occurrence rate of posterior visual system dama...
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| Published in: | Frontiers in Neurology Vol. 10; p. 455 |
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| Main Authors: | , , , , , , , , , |
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| Language: | English |
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| Abstract | Over the last few years there has been growing interest in use of visual measures as useful tools for multiple sclerosis (MS) prognosis and tracking. Optic neuritis (ON) being a prevalent and often-presenting symptom of the disease, as well as the high occurrence rate of posterior visual system damage independent of ON (optic radiation lesions), make the visual system a prime candidate for such endeavors. However, while the visual system makes for a convenient model in early stages of MS, processes which may be true in those stages may drastically change as the disease progresses, due to accumulated disease load. Here, we examine whether vision-related tools reflect demyelinative and axonal damage of the visual pathways and may be used for assessment in the clinical setup in progressive multiple sclerosis (MS) patients, in whom disease load may alter the early stage picture.
Forty-eight progressive MS patients, with and without prior optic neuritis (ON), underwent a battery of behavioral tests, visual evoked potential (VEP) tests, optical coherence tomography (OCT), and structural MRI scans, at two time-points. Data were analyzed for stability between visits and for correlation between behavioral and electrophysiological data.
All measures were stable between visits. Significant differences were found in all measures between the affected and fellow eyes of ON patients and in VEP latencies between the affected and non-ON eyes. Motion perception differentially correlated with latencies of both ON eyes and with the non-ON eyes. Retinal nerve fiber layer thickness correlated with the latencies of non-ON eyes but not of either ON eye. No difference in lesion load was found between the ON and non-ON patients.
ON still leaves its mark in the patient's visual system over time, with all visual measures of the affected eyes notably reduced compared to fellow eyes. Motion perception, reflecting myelination level along the visual pathway, shows its usefulness also in progressive MS. In the non-ON eyes, axonal loss appears to explain prolonged latencies, unlike in ON eyes, where demyelination appears to be the main mechanism. Lastly, the visual measures assessed herein are applicable as valid assessment tools in therapeutic studies. |
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| AbstractList | Background: Over the last few years there has been growing interest in use of visual measures as useful tools for multiple sclerosis (MS) prognosis and tracking. Optic neuritis (ON) being a prevalent and often-presenting symptom of the disease, as well as the high occurrence rate of posterior visual system damage independent of ON (optic radiation lesions), make the visual system a prime candidate for such endeavors. However, while the visual system makes for a convenient model in early stages of MS, processes which may be true in those stages may drastically change as the disease progresses, due to accumulated disease load. Here, we examine whether vision-related tools reflect demyelinative and axonal damage of the visual pathways and may be used for assessment in the clinical setup in progressive multiple sclerosis (MS) patients, in whom disease load may alter the early stage picture. Methods: Forty-eight progressive MS patients, with and without prior optic neuritis (ON), underwent a battery of behavioral tests, visual evoked potential (VEP) tests, optical coherence tomography (OCT), and structural MRI scans, at two time-points. Data were analyzed for stability between visits and for correlation between behavioral and electrophysiological data. Results: All measures were stable between visits. Significant differences were found in all measures between the affected and fellow eyes of ON patients and in VEP latencies between the affected and non-ON eyes. Motion perception differentially correlated with latencies of both ON eyes and with the non-ON eyes. Retinal nerve fiber layer thickness correlated with the latencies of non-ON eyes but not of either ON eye. No difference in lesion load was found between the ON and non-ON patients. Conclusions: ON still leaves its mark in the patient's visual system over time, with all visual measures of the affected eyes notably reduced compared to fellow eyes. Motion perception, reflecting myelination level along the visual pathway, shows its usefulness also in progressive MS. In the non-ON eyes, axonal loss appears to explain prolonged latencies, unlike in ON eyes, where demyelination appears to be the main mechanism. Lastly, the visual measures assessed herein are applicable as valid assessment tools in therapeutic studies.Background: Over the last few years there has been growing interest in use of visual measures as useful tools for multiple sclerosis (MS) prognosis and tracking. Optic neuritis (ON) being a prevalent and often-presenting symptom of the disease, as well as the high occurrence rate of posterior visual system damage independent of ON (optic radiation lesions), make the visual system a prime candidate for such endeavors. However, while the visual system makes for a convenient model in early stages of MS, processes which may be true in those stages may drastically change as the disease progresses, due to accumulated disease load. Here, we examine whether vision-related tools reflect demyelinative and axonal damage of the visual pathways and may be used for assessment in the clinical setup in progressive multiple sclerosis (MS) patients, in whom disease load may alter the early stage picture. Methods: Forty-eight progressive MS patients, with and without prior optic neuritis (ON), underwent a battery of behavioral tests, visual evoked potential (VEP) tests, optical coherence tomography (OCT), and structural MRI scans, at two time-points. Data were analyzed for stability between visits and for correlation between behavioral and electrophysiological data. Results: All measures were stable between visits. Significant differences were found in all measures between the affected and fellow eyes of ON patients and in VEP latencies between the affected and non-ON eyes. Motion perception differentially correlated with latencies of both ON eyes and with the non-ON eyes. Retinal nerve fiber layer thickness correlated with the latencies of non-ON eyes but not of either ON eye. No difference in lesion load was found between the ON and non-ON patients. Conclusions: ON still leaves its mark in the patient's visual system over time, with all visual measures of the affected eyes notably reduced compared to fellow eyes. Motion perception, reflecting myelination level along the visual pathway, shows its usefulness also in progressive MS. In the non-ON eyes, axonal loss appears to explain prolonged latencies, unlike in ON eyes, where demyelination appears to be the main mechanism. Lastly, the visual measures assessed herein are applicable as valid assessment tools in therapeutic studies. Background: Over the last few years there has been growing interest in use of visual measures as useful tools for multiple sclerosis (MS) prognosis and tracking. Optic neuritis (ON) being a prevalent and often-presenting symptom of the disease, as well as the high occurrence rate of posterior visual system damage independent of ON (optic radiation lesions), make the visual system a prime candidate for such endeavors. However, while the visual system makes for a convenient model in early stages of MS, processes which may be true in those stages may drastically change as the disease progresses, due to accumulated disease load. Here, we examine whether vision-related tools reflect demyelinative and axonal damage of the visual pathways and may be used for assessment in the clinical setup in progressive multiple sclerosis (MS) patients, in whom disease load may alter the early stage picture.Methods: Forty-eight progressive MS patients, with and without prior optic neuritis (ON), underwent a battery of behavioral tests, visual evoked potential (VEP) tests, optical coherence tomography (OCT), and structural MRI scans, at two time-points. Data were analyzed for stability between visits and for correlation between behavioral and electrophysiological data.Results: All measures were stable between visits. Significant differences were found in all measures between the affected and fellow eyes of ON patients and in VEP latencies between the affected and non-ON eyes. Motion perception differentially correlated with latencies of both ON eyes and with the non-ON eyes. Retinal nerve fiber layer thickness correlated with the latencies of non-ON eyes but not of either ON eye. No difference in lesion load was found between the ON and non-ON patients.Conclusions: ON still leaves its mark in the patient's visual system over time, with all visual measures of the affected eyes notably reduced compared to fellow eyes. Motion perception, reflecting myelination level along the visual pathway, shows its usefulness also in progressive MS. In the non-ON eyes, axonal loss appears to explain prolonged latencies, unlike in ON eyes, where demyelination appears to be the main mechanism. Lastly, the visual measures assessed herein are applicable as valid assessment tools in therapeutic studies. Over the last few years there has been growing interest in use of visual measures as useful tools for multiple sclerosis (MS) prognosis and tracking. Optic neuritis (ON) being a prevalent and often-presenting symptom of the disease, as well as the high occurrence rate of posterior visual system damage independent of ON (optic radiation lesions), make the visual system a prime candidate for such endeavors. However, while the visual system makes for a convenient model in early stages of MS, processes which may be true in those stages may drastically change as the disease progresses, due to accumulated disease load. Here, we examine whether vision-related tools reflect demyelinative and axonal damage of the visual pathways and may be used for assessment in the clinical setup in progressive multiple sclerosis (MS) patients, in whom disease load may alter the early stage picture. Forty-eight progressive MS patients, with and without prior optic neuritis (ON), underwent a battery of behavioral tests, visual evoked potential (VEP) tests, optical coherence tomography (OCT), and structural MRI scans, at two time-points. Data were analyzed for stability between visits and for correlation between behavioral and electrophysiological data. All measures were stable between visits. Significant differences were found in all measures between the affected and fellow eyes of ON patients and in VEP latencies between the affected and non-ON eyes. Motion perception differentially correlated with latencies of both ON eyes and with the non-ON eyes. Retinal nerve fiber layer thickness correlated with the latencies of non-ON eyes but not of either ON eye. No difference in lesion load was found between the ON and non-ON patients. ON still leaves its mark in the patient's visual system over time, with all visual measures of the affected eyes notably reduced compared to fellow eyes. Motion perception, reflecting myelination level along the visual pathway, shows its usefulness also in progressive MS. In the non-ON eyes, axonal loss appears to explain prolonged latencies, unlike in ON eyes, where demyelination appears to be the main mechanism. Lastly, the visual measures assessed herein are applicable as valid assessment tools in therapeutic studies. |
| Author | Dimitrios Karussis Michael Scheel Rebecca Jost Netta Levin Yael Backner Friedemann Paul Panayiota Petrou Noa Raz Hanna Zimmermann Haya Glick-Shames |
| AuthorAffiliation | 1 fMRI Unit, Neurology Department, Hadassah-Hebrew University Medical Center , Jerusalem , Israel 3 NeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health , Berlin , Germany 4 Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin , Berlin , Germany 2 Neurology Department, The Multiple Sclerosis Center, Hadassah-Hebrew University Medical Center , Jerusalem , Israel |
| AuthorAffiliation_xml | – name: 3 NeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health , Berlin , Germany – name: 1 fMRI Unit, Neurology Department, Hadassah-Hebrew University Medical Center , Jerusalem , Israel – name: 4 Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin , Berlin , Germany – name: 2 Neurology Department, The Multiple Sclerosis Center, Hadassah-Hebrew University Medical Center , Jerusalem , Israel |
| Author_xml | – sequence: 1 givenname: Yael surname: Backner fullname: Backner, Yael – sequence: 2 givenname: Panayiota surname: Petrou fullname: Petrou, Panayiota – sequence: 3 givenname: Haya surname: Glick-Shames fullname: Glick-Shames, Haya – sequence: 4 givenname: Noa surname: Raz fullname: Raz, Noa – sequence: 5 givenname: Hanna surname: Zimmermann fullname: Zimmermann, Hanna – sequence: 6 givenname: Rebecca surname: Jost fullname: Jost, Rebecca – sequence: 7 givenname: Michael surname: Scheel fullname: Scheel, Michael – sequence: 8 givenname: Friedemann surname: Paul fullname: Paul, Friedemann – sequence: 9 givenname: Dimitrios surname: Karussis fullname: Karussis, Dimitrios – sequence: 10 givenname: Netta surname: Levin fullname: Levin, Netta |
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| Cites_doi | 10.1007/s13167-017-0102-x 10.1177/1352458516649677 10.1177/1352458514538110 10.3109/02713683.2015.1119283 10.1002/ana.22005 10.1006/nimg.2002.1040 10.1016/j.jns.2015.07.037 10.1038/nrneurol.2014.108 10.1371/journal.pone.0102546 10.1016/S1474-4422(17)30278-8 10.18240/ijo.2018.02.24 10.1016/j.neuroimage.2004.07.051 10.1002/ana.22692 10.1016/j.neuroimage.2011.11.032 10.1016/j.neuroimage.2007.09.031 10.1212/WNL.0b013e3182a1aa3e 10.1177/1352458511431076 10.1097/WNO.0000000000000634 10.1016/S1474-4422(13)70259-X 10.1136/bmj.4.5893.661 10.1196/annals.1379.009 10.1212/NXI.0000000000000449 10.1007/s00330-014-3358-8 10.1212/WNL.0b013e31821f4602 10.1002/ana.22366 10.1212/WNL.0000000000000522 10.1212/NXI.0000000000000135 10.1093/brain/awu335 10.1001/jamaneurol.2017.3880 10.1016/j.ophtha.2007.08.004 10.1002/ana.20851 |
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| Copyright | Copyright © 2019 Backner, Petrou, Glick-Shames, Raz, Zimmermann, Jost, Scheel, Paul, Karussis and Levin. 2019 Backner, Petrou, Glick-Shames, Raz, Zimmermann, Jost, Scheel, Paul, Karussis and Levin |
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| Keywords | VEP OCT fellow eye motion perception multiple sclerosis optic neuritis |
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| Snippet | Over the last few years there has been growing interest in use of visual measures as useful tools for multiple sclerosis (MS) prognosis and tracking. Optic... Background: Over the last few years there has been growing interest in use of visual measures as useful tools for multiple sclerosis (MS) prognosis and... |
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| SubjectTerms | fellow eye Function and Dysfunction of the Nervous System motion perception multiple sclerosis Neurology Neurology. Diseases of the nervous system OCT optic neuritis RC346-429 VEP |
| Title | Vision and Vision-Related Measures in Progressive Multiple Sclerosis |
| URI | https://cir.nii.ac.jp/crid/1872835443063001728 https://www.ncbi.nlm.nih.gov/pubmed/31130910 https://www.proquest.com/docview/2232124618 https://pubmed.ncbi.nlm.nih.gov/PMC6509148 https://doaj.org/article/946be2286b8644b997bae3b057c1fb0a |
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