Vision and Vision-Related Measures in Progressive Multiple Sclerosis
Over the last few years there has been growing interest in use of visual measures as useful tools for multiple sclerosis (MS) prognosis and tracking. Optic neuritis (ON) being a prevalent and often-presenting symptom of the disease, as well as the high occurrence rate of posterior visual system dama...
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| Vydané v: | Frontiers in Neurology Ročník 10; s. 455 |
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| Hlavní autori: | , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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Switzerland
Frontiers Media SA
03.05.2019
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| ISSN: | 1664-2295, 1664-2295 |
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| Abstract | Over the last few years there has been growing interest in use of visual measures as useful tools for multiple sclerosis (MS) prognosis and tracking. Optic neuritis (ON) being a prevalent and often-presenting symptom of the disease, as well as the high occurrence rate of posterior visual system damage independent of ON (optic radiation lesions), make the visual system a prime candidate for such endeavors. However, while the visual system makes for a convenient model in early stages of MS, processes which may be true in those stages may drastically change as the disease progresses, due to accumulated disease load. Here, we examine whether vision-related tools reflect demyelinative and axonal damage of the visual pathways and may be used for assessment in the clinical setup in progressive multiple sclerosis (MS) patients, in whom disease load may alter the early stage picture.
Forty-eight progressive MS patients, with and without prior optic neuritis (ON), underwent a battery of behavioral tests, visual evoked potential (VEP) tests, optical coherence tomography (OCT), and structural MRI scans, at two time-points. Data were analyzed for stability between visits and for correlation between behavioral and electrophysiological data.
All measures were stable between visits. Significant differences were found in all measures between the affected and fellow eyes of ON patients and in VEP latencies between the affected and non-ON eyes. Motion perception differentially correlated with latencies of both ON eyes and with the non-ON eyes. Retinal nerve fiber layer thickness correlated with the latencies of non-ON eyes but not of either ON eye. No difference in lesion load was found between the ON and non-ON patients.
ON still leaves its mark in the patient's visual system over time, with all visual measures of the affected eyes notably reduced compared to fellow eyes. Motion perception, reflecting myelination level along the visual pathway, shows its usefulness also in progressive MS. In the non-ON eyes, axonal loss appears to explain prolonged latencies, unlike in ON eyes, where demyelination appears to be the main mechanism. Lastly, the visual measures assessed herein are applicable as valid assessment tools in therapeutic studies. |
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| AbstractList | Background: Over the last few years there has been growing interest in use of visual measures as useful tools for multiple sclerosis (MS) prognosis and tracking. Optic neuritis (ON) being a prevalent and often-presenting symptom of the disease, as well as the high occurrence rate of posterior visual system damage independent of ON (optic radiation lesions), make the visual system a prime candidate for such endeavors. However, while the visual system makes for a convenient model in early stages of MS, processes which may be true in those stages may drastically change as the disease progresses, due to accumulated disease load. Here, we examine whether vision-related tools reflect demyelinative and axonal damage of the visual pathways and may be used for assessment in the clinical setup in progressive multiple sclerosis (MS) patients, in whom disease load may alter the early stage picture. Methods: Forty-eight progressive MS patients, with and without prior optic neuritis (ON), underwent a battery of behavioral tests, visual evoked potential (VEP) tests, optical coherence tomography (OCT), and structural MRI scans, at two time-points. Data were analyzed for stability between visits and for correlation between behavioral and electrophysiological data. Results: All measures were stable between visits. Significant differences were found in all measures between the affected and fellow eyes of ON patients and in VEP latencies between the affected and non-ON eyes. Motion perception differentially correlated with latencies of both ON eyes and with the non-ON eyes. Retinal nerve fiber layer thickness correlated with the latencies of non-ON eyes but not of either ON eye. No difference in lesion load was found between the ON and non-ON patients. Conclusions: ON still leaves its mark in the patient's visual system over time, with all visual measures of the affected eyes notably reduced compared to fellow eyes. Motion perception, reflecting myelination level along the visual pathway, shows its usefulness also in progressive MS. In the non-ON eyes, axonal loss appears to explain prolonged latencies, unlike in ON eyes, where demyelination appears to be the main mechanism. Lastly, the visual measures assessed herein are applicable as valid assessment tools in therapeutic studies.Background: Over the last few years there has been growing interest in use of visual measures as useful tools for multiple sclerosis (MS) prognosis and tracking. Optic neuritis (ON) being a prevalent and often-presenting symptom of the disease, as well as the high occurrence rate of posterior visual system damage independent of ON (optic radiation lesions), make the visual system a prime candidate for such endeavors. However, while the visual system makes for a convenient model in early stages of MS, processes which may be true in those stages may drastically change as the disease progresses, due to accumulated disease load. Here, we examine whether vision-related tools reflect demyelinative and axonal damage of the visual pathways and may be used for assessment in the clinical setup in progressive multiple sclerosis (MS) patients, in whom disease load may alter the early stage picture. Methods: Forty-eight progressive MS patients, with and without prior optic neuritis (ON), underwent a battery of behavioral tests, visual evoked potential (VEP) tests, optical coherence tomography (OCT), and structural MRI scans, at two time-points. Data were analyzed for stability between visits and for correlation between behavioral and electrophysiological data. Results: All measures were stable between visits. Significant differences were found in all measures between the affected and fellow eyes of ON patients and in VEP latencies between the affected and non-ON eyes. Motion perception differentially correlated with latencies of both ON eyes and with the non-ON eyes. Retinal nerve fiber layer thickness correlated with the latencies of non-ON eyes but not of either ON eye. No difference in lesion load was found between the ON and non-ON patients. Conclusions: ON still leaves its mark in the patient's visual system over time, with all visual measures of the affected eyes notably reduced compared to fellow eyes. Motion perception, reflecting myelination level along the visual pathway, shows its usefulness also in progressive MS. In the non-ON eyes, axonal loss appears to explain prolonged latencies, unlike in ON eyes, where demyelination appears to be the main mechanism. Lastly, the visual measures assessed herein are applicable as valid assessment tools in therapeutic studies. Background: Over the last few years there has been growing interest in use of visual measures as useful tools for multiple sclerosis (MS) prognosis and tracking. Optic neuritis (ON) being a prevalent and often-presenting symptom of the disease, as well as the high occurrence rate of posterior visual system damage independent of ON (optic radiation lesions), make the visual system a prime candidate for such endeavors. However, while the visual system makes for a convenient model in early stages of MS, processes which may be true in those stages may drastically change as the disease progresses, due to accumulated disease load. Here, we examine whether vision-related tools reflect demyelinative and axonal damage of the visual pathways and may be used for assessment in the clinical setup in progressive multiple sclerosis (MS) patients, in whom disease load may alter the early stage picture.Methods: Forty-eight progressive MS patients, with and without prior optic neuritis (ON), underwent a battery of behavioral tests, visual evoked potential (VEP) tests, optical coherence tomography (OCT), and structural MRI scans, at two time-points. Data were analyzed for stability between visits and for correlation between behavioral and electrophysiological data.Results: All measures were stable between visits. Significant differences were found in all measures between the affected and fellow eyes of ON patients and in VEP latencies between the affected and non-ON eyes. Motion perception differentially correlated with latencies of both ON eyes and with the non-ON eyes. Retinal nerve fiber layer thickness correlated with the latencies of non-ON eyes but not of either ON eye. No difference in lesion load was found between the ON and non-ON patients.Conclusions: ON still leaves its mark in the patient's visual system over time, with all visual measures of the affected eyes notably reduced compared to fellow eyes. Motion perception, reflecting myelination level along the visual pathway, shows its usefulness also in progressive MS. In the non-ON eyes, axonal loss appears to explain prolonged latencies, unlike in ON eyes, where demyelination appears to be the main mechanism. Lastly, the visual measures assessed herein are applicable as valid assessment tools in therapeutic studies. Over the last few years there has been growing interest in use of visual measures as useful tools for multiple sclerosis (MS) prognosis and tracking. Optic neuritis (ON) being a prevalent and often-presenting symptom of the disease, as well as the high occurrence rate of posterior visual system damage independent of ON (optic radiation lesions), make the visual system a prime candidate for such endeavors. However, while the visual system makes for a convenient model in early stages of MS, processes which may be true in those stages may drastically change as the disease progresses, due to accumulated disease load. Here, we examine whether vision-related tools reflect demyelinative and axonal damage of the visual pathways and may be used for assessment in the clinical setup in progressive multiple sclerosis (MS) patients, in whom disease load may alter the early stage picture. Forty-eight progressive MS patients, with and without prior optic neuritis (ON), underwent a battery of behavioral tests, visual evoked potential (VEP) tests, optical coherence tomography (OCT), and structural MRI scans, at two time-points. Data were analyzed for stability between visits and for correlation between behavioral and electrophysiological data. All measures were stable between visits. Significant differences were found in all measures between the affected and fellow eyes of ON patients and in VEP latencies between the affected and non-ON eyes. Motion perception differentially correlated with latencies of both ON eyes and with the non-ON eyes. Retinal nerve fiber layer thickness correlated with the latencies of non-ON eyes but not of either ON eye. No difference in lesion load was found between the ON and non-ON patients. ON still leaves its mark in the patient's visual system over time, with all visual measures of the affected eyes notably reduced compared to fellow eyes. Motion perception, reflecting myelination level along the visual pathway, shows its usefulness also in progressive MS. In the non-ON eyes, axonal loss appears to explain prolonged latencies, unlike in ON eyes, where demyelination appears to be the main mechanism. Lastly, the visual measures assessed herein are applicable as valid assessment tools in therapeutic studies. |
| Author | Dimitrios Karussis Michael Scheel Rebecca Jost Netta Levin Yael Backner Friedemann Paul Panayiota Petrou Noa Raz Hanna Zimmermann Haya Glick-Shames |
| AuthorAffiliation | 1 fMRI Unit, Neurology Department, Hadassah-Hebrew University Medical Center , Jerusalem , Israel 3 NeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health , Berlin , Germany 4 Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin , Berlin , Germany 2 Neurology Department, The Multiple Sclerosis Center, Hadassah-Hebrew University Medical Center , Jerusalem , Israel |
| AuthorAffiliation_xml | – name: 3 NeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health , Berlin , Germany – name: 1 fMRI Unit, Neurology Department, Hadassah-Hebrew University Medical Center , Jerusalem , Israel – name: 4 Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité-Universitätsmedizin Berlin , Berlin , Germany – name: 2 Neurology Department, The Multiple Sclerosis Center, Hadassah-Hebrew University Medical Center , Jerusalem , Israel |
| Author_xml | – sequence: 1 givenname: Yael surname: Backner fullname: Backner, Yael – sequence: 2 givenname: Panayiota surname: Petrou fullname: Petrou, Panayiota – sequence: 3 givenname: Haya surname: Glick-Shames fullname: Glick-Shames, Haya – sequence: 4 givenname: Noa surname: Raz fullname: Raz, Noa – sequence: 5 givenname: Hanna surname: Zimmermann fullname: Zimmermann, Hanna – sequence: 6 givenname: Rebecca surname: Jost fullname: Jost, Rebecca – sequence: 7 givenname: Michael surname: Scheel fullname: Scheel, Michael – sequence: 8 givenname: Friedemann surname: Paul fullname: Paul, Friedemann – sequence: 9 givenname: Dimitrios surname: Karussis fullname: Karussis, Dimitrios – sequence: 10 givenname: Netta surname: Levin fullname: Levin, Netta |
| BackLink | https://cir.nii.ac.jp/crid/1872835443063001728$$DView record in CiNii https://www.ncbi.nlm.nih.gov/pubmed/31130910$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_clinph_2024_02_020 crossref_primary_10_1007_s00415_021_10561_2 crossref_primary_10_1016_j_msard_2022_104116 crossref_primary_10_3390_s20010007 crossref_primary_10_1038_s41582_024_01006_1 crossref_primary_10_3389_fnins_2021_692599 crossref_primary_10_4103_njcp_njcp_1568_21 crossref_primary_10_1016_j_msard_2021_103349 crossref_primary_10_1177_13524585211032801 crossref_primary_10_25259_SNI_719_2024 crossref_primary_10_7759_cureus_56094 crossref_primary_10_1016_j_neuroimage_2020_117204 crossref_primary_10_1007_s00415_023_12075_5 crossref_primary_10_1007_s00415_024_12803_5 crossref_primary_10_3389_fnmol_2023_1125115 crossref_primary_10_1016_j_clinph_2022_02_013 crossref_primary_10_3390_jcm11102936 crossref_primary_10_1002_hbm_25744 crossref_primary_10_3390_cells10061507 crossref_primary_10_3389_fneur_2020_00450 |
| Cites_doi | 10.1007/s13167-017-0102-x 10.1177/1352458516649677 10.1177/1352458514538110 10.3109/02713683.2015.1119283 10.1002/ana.22005 10.1006/nimg.2002.1040 10.1016/j.jns.2015.07.037 10.1038/nrneurol.2014.108 10.1371/journal.pone.0102546 10.1016/S1474-4422(17)30278-8 10.18240/ijo.2018.02.24 10.1016/j.neuroimage.2004.07.051 10.1002/ana.22692 10.1016/j.neuroimage.2011.11.032 10.1016/j.neuroimage.2007.09.031 10.1212/WNL.0b013e3182a1aa3e 10.1177/1352458511431076 10.1097/WNO.0000000000000634 10.1016/S1474-4422(13)70259-X 10.1136/bmj.4.5893.661 10.1196/annals.1379.009 10.1212/NXI.0000000000000449 10.1007/s00330-014-3358-8 10.1212/WNL.0b013e31821f4602 10.1002/ana.22366 10.1212/WNL.0000000000000522 10.1212/NXI.0000000000000135 10.1093/brain/awu335 10.1001/jamaneurol.2017.3880 10.1016/j.ophtha.2007.08.004 10.1002/ana.20851 |
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| Copyright | Copyright © 2019 Backner, Petrou, Glick-Shames, Raz, Zimmermann, Jost, Scheel, Paul, Karussis and Levin. 2019 Backner, Petrou, Glick-Shames, Raz, Zimmermann, Jost, Scheel, Paul, Karussis and Levin |
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| Keywords | VEP OCT fellow eye motion perception multiple sclerosis optic neuritis |
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| References | Polman (B12) 2011; 69 Langdon (B13) 2012; 18 Oberwahrenbrock (B8) 2018; 5 Raz (B4) 2011; 76 Petzold (B7) 2017; 16 Smith (B17) 2002; 17 Talman (B6) 2010; 67 Klistorner (B28) 2014; 82 Raz (B20) 2012; 71 Halliday (B23) 1973; 4 Raz (B24) 2013; 81 Group (B22) 2008; 115 Backner (B32) 2018; 38 Backner (B10) 2018; 75 Alshowaeir (B27) 2018; 11 Schippling (B15) 2015; 21 Petzold (B1) 2014; 10 Sriram (B30) 2014; 9 Galetta (B2) 2015; 2 (B21) 1988; 2 Esen (B31) 2016; 41 Smith (B18) 2004; 23 Shattuck (B19) 2008; 39 Sinnecker (B29) 2015; 25 Benoliel (B25) 2016; 23 Toosy (B11) 2014; 13 Balcer (B3) 2014; 138 Raz (B14) 2015; 357 Schmidt (B16) 2012; 59 Costello (B5) 2006; 59 Sperling (B26) 2007; 1097 Kuchling (B9) 2017; 8 |
| References_xml | – volume: 8 start-page: 279 year: 2017 ident: B9 article-title: Diffusion tensor imaging for multilevel assessment of the visual pathway: possibilities for personalized outcome prediction in autoimmune disorders of the central nervous system publication-title: EPMA J. doi: 10.1007/s13167-017-0102-x – volume: 23 start-page: 220 year: 2016 ident: B25 article-title: Cortical functional modifications following optic neuritis publication-title: Mult Scler. doi: 10.1177/1352458516649677 – volume: 21 start-page: 163 year: 2015 ident: B15 article-title: Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria publication-title: Multiple Scler J. doi: 10.1177/1352458514538110 – volume: 41 start-page: 1353 year: 2016 ident: B31 article-title: Evaluation of the innermost retinal layers and visual evoked potentials in patients with multiple sclerosis publication-title: Curr Eye Res. doi: 10.3109/02713683.2015.1119283 – volume: 67 start-page: 749 year: 2010 ident: B6 article-title: Longitudinal study of vision and retinal nerve fiber layer thickness in multiple sclerosis publication-title: Ann Neurol. doi: 10.1002/ana.22005 – volume: 17 start-page: 479 year: 2002 ident: B17 article-title: Accurate, robust, and automated longitudinal and cross-sectional brain change analysis publication-title: Neuroimage. doi: 10.1006/nimg.2002.1040 – volume: 357 start-page: 235 year: 2015 ident: B14 article-title: Temporal aspects of visual perception in demyelinative diseases publication-title: J Neurol Sci. doi: 10.1016/j.jns.2015.07.037 – volume: 10 start-page: 447 year: 2014 ident: B1 article-title: The investigation of acute optic neuritis: a review and proposed protocol publication-title: Nat Rev Neurol. doi: 10.1038/nrneurol.2014.108 – volume: 9 start-page: e102546 year: 2014 ident: B30 article-title: Relationship between optical coherence tomography and electrophysiology of the visual pathway in non-optic neuritis eyes of multiple sclerosis patients publication-title: PLoS ONE. doi: 10.1371/journal.pone.0102546 – volume: 16 start-page: 797 year: 2017 ident: B7 article-title: Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(17)30278-8 – volume: 11 start-page: 329 year: 2018 ident: B27 article-title: Mechanism of delayed conduction of fellow eyes in patients with optic neuritis publication-title: Int J Ophthalmol. doi: 10.18240/ijo.2018.02.24 – volume: 23 start-page: S208 year: 2004 ident: B18 article-title: Advances in functional and structural MR image analysis and implementation as FSL publication-title: Neuroimage. doi: 10.1016/j.neuroimage.2004.07.051 – volume: 71 start-page: 531 year: 2012 ident: B20 article-title: Demyelination affects temporal aspects of perception: an optic neuritis study publication-title: Ann Neurol. doi: 10.1002/ana.22692 – volume: 59 start-page: 3774 year: 2012 ident: B16 article-title: An automated tool for detection of FLAIR-hyperintense white-matter lesions in multiple sclerosis publication-title: Neuroimage. doi: 10.1016/j.neuroimage.2011.11.032 – volume: 39 start-page: 1064 year: 2008 ident: B19 article-title: Construction of a 3D probabilistic atlas of human cortical structures publication-title: Neuroimage. doi: 10.1016/j.neuroimage.2007.09.031 – volume: 81 start-page: 702 year: 2013 ident: B24 article-title: Temporal reorganization to overcome monocular demyelination publication-title: Neurology. doi: 10.1212/WNL.0b013e3182a1aa3e – volume: 18 start-page: 891 year: 2012 ident: B13 article-title: Recommendations for a brief international cognitive assessment for multiple sclerosis (BICAMS) publication-title: Multiple Sclerosis J. doi: 10.1177/1352458511431076 – volume: 38 start-page: 85 year: 2018 ident: B32 article-title: Keep your eyes wide open: on visual-and vision-related measurements to better understand multiple sclerosis pathophysiology publication-title: J Neuro-Ophthalmol. doi: 10.1097/WNO.0000000000000634 – volume: 13 start-page: 83 year: 2014 ident: B11 article-title: Optic neuritis publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(13)70259-X – volume: 4 start-page: 661 year: 1973 ident: B23 article-title: Visual evoked response in diagnosis of multiple sclerosis publication-title: Br Med J. doi: 10.1136/bmj.4.5893.661 – volume: 1097 start-page: 146 year: 2007 ident: B26 article-title: Functional MRI studies of associative encoding in normal aging, mild cognitive impairment, and Alzheimer's disease publication-title: Ann N Y Acad Sci. doi: 10.1196/annals.1379.009 – volume: 5 start-page: e449 year: 2018 ident: B8 article-title: Multicenter reliability of semiautomatic retinal layer segmentation using OCT publication-title: Neurol Neuroimmunol Neuroinflamm. doi: 10.1212/NXI.0000000000000449 – volume: 25 start-page: 122 year: 2015 ident: B29 article-title: Optic radiation damage in multiple sclerosis is associated with visual dysfunction and retinal thinning-an ultrahigh-field MR pilot study publication-title: Eur Radiol. doi: 10.1007/s00330-014-3358-8 – volume: 76 start-page: 2103 year: 2011 ident: B4 article-title: Sustained motion perception deficit following optic neuritis behavioral and cortical evidence publication-title: Neurology. doi: 10.1212/WNL.0b013e31821f4602 – volume: 69 start-page: 292 year: 2011 ident: B12 article-title: Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria publication-title: Ann Neurol. doi: 10.1002/ana.22366 – volume: 82 start-page: 2165 year: 2014 ident: B28 article-title: Axonal loss of retinal neurons in multiple sclerosis associated with optic radiation lesions publication-title: Neurology. doi: 10.1212/WNL.0000000000000522 – volume: 2 start-page: e135 year: 2015 ident: B2 article-title: Acute optic neuritis Unmet clinical needs and model for new therapies publication-title: Neurol Neuroimmunol Neuroinflamm. doi: 10.1212/NXI.0000000000000135 – volume: 138 start-page: 11 year: 2014 ident: B3 article-title: Vision and vision-related outcome measures in multiple sclerosis publication-title: Brain. doi: 10.1093/brain/awu335 – volume: 75 start-page: 287 year: 2018 ident: B10 article-title: Anatomical wiring and functional networking changes in the visual system following optic neuritis publication-title: JAMA Neurol. doi: 10.1001/jamaneurol.2017.3880 – volume: 115 start-page: e1075 year: 2008 ident: B22 article-title: Visual function 15 years after optic neuritis: a final follow-up report from the optic neuritis treatment trial publication-title: Ophthalmology. doi: 10.1016/j.ophtha.2007.08.004 – volume: 2 start-page: 1 year: 1988 ident: B21 article-title: Visual acuity measurement standard publication-title: Italian J Ophthalmol. – volume: 59 start-page: 963 year: 2006 ident: B5 article-title: Quantifying axonal loss after optic neuritis with optical coherence tomography publication-title: Ann Neurol. doi: 10.1002/ana.20851 |
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| Snippet | Over the last few years there has been growing interest in use of visual measures as useful tools for multiple sclerosis (MS) prognosis and tracking. Optic... Background: Over the last few years there has been growing interest in use of visual measures as useful tools for multiple sclerosis (MS) prognosis and... |
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| SubjectTerms | fellow eye Function and Dysfunction of the Nervous System motion perception multiple sclerosis Neurology Neurology. Diseases of the nervous system OCT optic neuritis RC346-429 VEP |
| Title | Vision and Vision-Related Measures in Progressive Multiple Sclerosis |
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