Vision and Vision-Related Measures in Progressive Multiple Sclerosis

Over the last few years there has been growing interest in use of visual measures as useful tools for multiple sclerosis (MS) prognosis and tracking. Optic neuritis (ON) being a prevalent and often-presenting symptom of the disease, as well as the high occurrence rate of posterior visual system dama...

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Vydané v:Frontiers in Neurology Ročník 10; s. 455
Hlavní autori: Backner, Yael, Petrou, Panayiota, Glick-Shames, Haya, Raz, Noa, Zimmermann, Hanna, Jost, Rebecca, Scheel, Michael, Paul, Friedemann, Karussis, Dimitrios, Levin, Netta
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland Frontiers Media SA 03.05.2019
Frontiers Media S.A
Predmet:
fellow eye
Function and Dysfunction of the Nervous System
motion perception
multiple sclerosis
Neurology
Neurology. Diseases of the nervous system
OCT
optic neuritis
RC346-429
VEP
VEP
OCT
fellow eye
motion perception
multiple sclerosis
optic neuritis
ISSN:1664-2295, 1664-2295
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Shrnutí:Over the last few years there has been growing interest in use of visual measures as useful tools for multiple sclerosis (MS) prognosis and tracking. Optic neuritis (ON) being a prevalent and often-presenting symptom of the disease, as well as the high occurrence rate of posterior visual system damage independent of ON (optic radiation lesions), make the visual system a prime candidate for such endeavors. However, while the visual system makes for a convenient model in early stages of MS, processes which may be true in those stages may drastically change as the disease progresses, due to accumulated disease load. Here, we examine whether vision-related tools reflect demyelinative and axonal damage of the visual pathways and may be used for assessment in the clinical setup in progressive multiple sclerosis (MS) patients, in whom disease load may alter the early stage picture. Forty-eight progressive MS patients, with and without prior optic neuritis (ON), underwent a battery of behavioral tests, visual evoked potential (VEP) tests, optical coherence tomography (OCT), and structural MRI scans, at two time-points. Data were analyzed for stability between visits and for correlation between behavioral and electrophysiological data. All measures were stable between visits. Significant differences were found in all measures between the affected and fellow eyes of ON patients and in VEP latencies between the affected and non-ON eyes. Motion perception differentially correlated with latencies of both ON eyes and with the non-ON eyes. Retinal nerve fiber layer thickness correlated with the latencies of non-ON eyes but not of either ON eye. No difference in lesion load was found between the ON and non-ON patients. ON still leaves its mark in the patient's visual system over time, with all visual measures of the affected eyes notably reduced compared to fellow eyes. Motion perception, reflecting myelination level along the visual pathway, shows its usefulness also in progressive MS. In the non-ON eyes, axonal loss appears to explain prolonged latencies, unlike in ON eyes, where demyelination appears to be the main mechanism. Lastly, the visual measures assessed herein are applicable as valid assessment tools in therapeutic studies.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
Edited by: Letizia Leocani, San Raffaele Hospital (IRCCS), Italy
This article was submitted to Multiple Sclerosis and Neuroimmunology, a section of the journal Frontiers in Neurology
Reviewed by: Edgar Carnero Contentti, Hospital Alemán, Argentina; Izumi Kawachi, Niigata University, Japan
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2019.00455