Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons

Dual leucine zipper kinase (DLK) has been implicated in cell death signaling secondary to axonal damage in retinal ganglion cells (RGCs) and other neurons. To better understand the pathway through which DLK acts, we developed enhanced functional genomic screens in primary RGCs, including use of arra...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Jg. 94; H. 6; S. 1142
Hauptverfasser:	Welsbie, Derek S, Mitchell, Katherine L, Jaskula-Ranga, Vinod, Sluch, Valentin M, Yang, Zhiyong, Kim, Jessica, Buehler, Eugen, Patel, Amit, Martin, Scott E, Zhang, Ping-Wu, Ge, Yan, Duan, Yukan, Fuller, John, Kim, Byung-Jin, Hamed, Eman, Chamling, Xitiz, Lei, Lei, Fraser, Iain D C, Ronai, Ze'ev A, Berlinicke, Cynthia A, Zack, Donald J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 21.06.2017
Schlagworte:	Animals Cell Death Cell Survival - drug effects Cell Survival - genetics Disease Models, Animal Flow Cytometry Human Embryonic Stem Cells - cytology Humans Immunoprecipitation MAP Kinase Kinase Kinases - genetics MAP Kinase Kinase Kinases - metabolism Mice Mice, Knockout Neurites Neurons Optic Nerve Injuries - genetics Optic Nerve Injuries - pathology Piperazines - pharmacology Protein Kinase Inhibitors - pharmacology Real-Time Polymerase Chain Reaction Retina - cytology Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - metabolism Retinal Ganglion Cells - pathology LZK (leucine zipper kinase) Neuroprotection RGC (retinal ganglion cell) RNAi screen glaucoma cell death signaling DLK (dual leucine zipper kinase)
ISSN:	1097-4199, 1097-4199
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