Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype

Fanconi anemia (FA) is a human genetic disease characterized by chromosome instability, cancer predisposition, and cellular hypersensitivity to DNA crosslinking agents. The FA pathway regulates the repair of DNA crosslinks. A critical step in this pathway is the monoubiquitination and deubiquitinati...

Full description

Saved in:

Bibliographic Details
Published in:	Developmental cell Vol. 16; no. 2; p. 314
Main Authors:	Kim, Jung Min, Parmar, Kalindi, Huang, Min, Weinstock, David M, Ruit, Carrie Ann, Kutok, Jeffrey L, D'Andrea, Alan D
Format:	Journal Article
Language:	English
Published:	United States 01.02.2009
Subjects:	Animals Arabidopsis Proteins Crosses, Genetic DNA Repair Endopeptidases - genetics Endopeptidases - physiology Fanconi Anemia - genetics Fanconi Anemia Complementation Group D2 Protein - metabolism Female Fibroblasts - metabolism Gene Deletion Genomic Instability Lymphocytes - metabolism Male Mice Mice, Knockout Phenotype Ubiquitin-Specific Proteases
ISSN:	1878-1551, 1878-1551
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!