Decoding Gray Matter Involvement in Multiple Sclerosis via Imaging

Multiple sclerosis (MS) is increasingly understood not only as a white matter disease but also involving both the deep and cortical gray matter (GM). GM pathology in people with MS (pwMS) includes the presence of lesions, leptomeningeal inflammation, atrophy, altered iron concentration, and microstr...

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Bibliographic Details
Published in:Neuroimaging clinics of North America Vol. 34; no. 3; p. 453
Main Authors: Zivadinov, Robert, Schweser, Ferdinand, Jakimovski, Dejan, Bergsland, Niels, Dwyer, Michael G
Format: Journal Article
Language:English
Published: United States 01.08.2024
Subjects:
Brain - diagnostic imaging
Brain - pathology
Gray Matter - diagnostic imaging
Gray Matter - pathology
Humans
Magnetic Resonance Imaging - methods
Multiple Sclerosis - diagnostic imaging
Multiple Sclerosis - pathology
Neuroimaging - methods
Atrophy
Iron concentration
3T
Cortical lesions
Pathology
Leptomeningeal inflammation
7T
Gray matter
ISSN:1557-9867, 1557-9867
Online Access:Get more information
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Summary:Multiple sclerosis (MS) is increasingly understood not only as a white matter disease but also involving both the deep and cortical gray matter (GM). GM pathology in people with MS (pwMS) includes the presence of lesions, leptomeningeal inflammation, atrophy, altered iron concentration, and microstructural changes. Studies using 7T and 3T MR imaging with optimized protocols established that GM damage is a principal driver of disease progression in pwMS. Future work is needed to incorporate the assessment of these GM imaging biomarkers into the clinical workup of pwMS and the assessment of treatment efficacy.
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ISSN:1557-9867
1557-9867
DOI:10.1016/j.nic.2024.03.007