High-Resolution CBV-fMRI Allows Mapping of Laminar Activity and Connectivity of Cortical Input and Output in Human M1

Layer-dependent fMRI allows measurements of information flow in cortical circuits, as afferent and efferent connections terminate in different cortical layers. However, it is unknown to what level human fMRI is specific and sensitive enough to reveal directional functional activity across layers. To...

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Vydané v:Neuron (Cambridge, Mass.) Ročník 96; číslo 6; s. 1253
Hlavní autori: Huber, Laurentius, Handwerker, Daniel A, Jangraw, David C, Chen, Gang, Hall, Andrew, Stüber, Carsten, Gonzalez-Castillo, Javier, Ivanov, Dimo, Marrett, Sean, Guidi, Maria, Goense, Jozien, Poser, Benedikt A, Bandettini, Peter A
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 20.12.2017
Predmet:
Brain - blood supply
Brain Mapping
Cerebrovascular Circulation - physiology
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Motor Cortex - diagnostic imaging
Motor Cortex - physiology
Oxygen - blood
Rest
cortical layers
neurovascular coupling
fMRI
BOLD
layer fMRI
VASO
ISSN:1097-4199, 1097-4199
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Popis
Shrnutí:Layer-dependent fMRI allows measurements of information flow in cortical circuits, as afferent and efferent connections terminate in different cortical layers. However, it is unknown to what level human fMRI is specific and sensitive enough to reveal directional functional activity across layers. To answer this question, we developed acquisition and analysis methods for blood-oxygen-level-dependent (BOLD) and cerebral-blood-volume (CBV)-based laminar fMRI and used these to discriminate four different tasks in the human motor cortex (M1). In agreement with anatomical data from animal studies, we found evidence for somatosensory and premotor input in superficial layers of M1 and for cortico-spinal motor output in deep layers. Laminar resting-state fMRI showed directional functional connectivity of M1 with somatosensory and premotor areas. Our findings demonstrate that CBV-fMRI can be used to investigate cortical activity in humans with unprecedented detail, allowing investigations of information flow between brain regions and outperforming conventional BOLD results that are often buried under vascular biases.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1097-4199
1097-4199
DOI:10.1016/j.neuron.2017.11.005