Spatial Representations of Granule Cells and Mossy Cells of the Dentate Gyrus

Granule cells in the dentate gyrus of the hippocampus are thought to be essential to memory function by decorrelating overlapping input patterns (pattern separation). A second excitatory cell type in the dentate gyrus, the mossy cell, forms an intricate circuit with granule cells, CA3c pyramidal cel...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Jg. 93; H. 3; S. 677
Hauptverfasser:	GoodSmith, Douglas, Chen, Xiaojing, Wang, Cheng, Kim, Sang Hoon, Song, Hongjun, Burgalossi, Andrea, Christian, Kimberly M, Knierim, James J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 08.02.2017
Schlagworte:	Action Potentials - physiology Animals Brain Mapping CA3 Region, Hippocampal - cytology CA3 Region, Hippocampal - physiology Decision Trees Dentate Gyrus - cytology Dentate Gyrus - physiology Exploratory Behavior - physiology Interneurons - cytology Interneurons - physiology Memory Models, Neurological Mossy Fibers, Hippocampal - physiology Neurons - cytology Neurons - physiology Pyramidal Cells - cytology Pyramidal Cells - physiology Rats Rats, Long-Evans Spatial Processing - physiology dentate gyrus pattern separation hilus mossy cell granule cell
ISSN:	1097-4199, 1097-4199
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Abstract	Granule cells in the dentate gyrus of the hippocampus are thought to be essential to memory function by decorrelating overlapping input patterns (pattern separation). A second excitatory cell type in the dentate gyrus, the mossy cell, forms an intricate circuit with granule cells, CA3c pyramidal cells, and local interneurons, but the influence of mossy cells on dentate function is often overlooked. Multiple tetrode recordings, supported by juxtacellular recording techniques, showed that granule cells fired very sparsely, whereas mossy cells in the hilus fired promiscuously in multiple locations and in multiple environments. The activity patterns of these cell types thus represent different environments through distinct computational mechanisms: sparse coding in granule cells and changes in firing field locations in mossy cells.
AbstractList	Granule cells in the dentate gyrus of the hippocampus are thought to be essential to memory function by decorrelating overlapping input patterns (pattern separation). A second excitatory cell type in the dentate gyrus, the mossy cell, forms an intricate circuit with granule cells, CA3c pyramidal cells, and local interneurons, but the influence of mossy cells on dentate function is often overlooked. Multiple tetrode recordings, supported by juxtacellular recording techniques, showed that granule cells fired very sparsely, whereas mossy cells in the hilus fired promiscuously in multiple locations and in multiple environments. The activity patterns of these cell types thus represent different environments through distinct computational mechanisms: sparse coding in granule cells and changes in firing field locations in mossy cells.Granule cells in the dentate gyrus of the hippocampus are thought to be essential to memory function by decorrelating overlapping input patterns (pattern separation). A second excitatory cell type in the dentate gyrus, the mossy cell, forms an intricate circuit with granule cells, CA3c pyramidal cells, and local interneurons, but the influence of mossy cells on dentate function is often overlooked. Multiple tetrode recordings, supported by juxtacellular recording techniques, showed that granule cells fired very sparsely, whereas mossy cells in the hilus fired promiscuously in multiple locations and in multiple environments. The activity patterns of these cell types thus represent different environments through distinct computational mechanisms: sparse coding in granule cells and changes in firing field locations in mossy cells. Granule cells in the dentate gyrus of the hippocampus are thought to be essential to memory function by decorrelating overlapping input patterns (pattern separation). A second excitatory cell type in the dentate gyrus, the mossy cell, forms an intricate circuit with granule cells, CA3c pyramidal cells, and local interneurons, but the influence of mossy cells on dentate function is often overlooked. Multiple tetrode recordings, supported by juxtacellular recording techniques, showed that granule cells fired very sparsely, whereas mossy cells in the hilus fired promiscuously in multiple locations and in multiple environments. The activity patterns of these cell types thus represent different environments through distinct computational mechanisms: sparse coding in granule cells and changes in firing field locations in mossy cells.
Author	Chen, Xiaojing Kim, Sang Hoon GoodSmith, Douglas Christian, Kimberly M Knierim, James J Wang, Cheng Burgalossi, Andrea Song, Hongjun
Author_xml	– sequence: 1 givenname: Douglas surname: GoodSmith fullname: GoodSmith, Douglas organization: Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA – sequence: 2 givenname: Xiaojing surname: Chen fullname: Chen, Xiaojing organization: Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA – sequence: 3 givenname: Cheng surname: Wang fullname: Wang, Cheng organization: Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA – sequence: 4 givenname: Sang Hoon surname: Kim fullname: Kim, Sang Hoon organization: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore MD 21205 USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore MD 21205 USA – sequence: 5 givenname: Hongjun surname: Song fullname: Song, Hongjun organization: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore MD 21205 USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore MD 21205 USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore MD 21205 USA – sequence: 6 givenname: Andrea surname: Burgalossi fullname: Burgalossi, Andrea organization: Werner-Reichardt Centre for Integrative Neuroscience, 72076 Tübingen, Germany – sequence: 7 givenname: Kimberly M surname: Christian fullname: Christian, Kimberly M organization: Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore MD 21205 USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore MD 21205 USA – sequence: 8 givenname: James J surname: Knierim fullname: Knierim, James J email: jknierim@jhu.edu organization: Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore MD 21205 USA. Electronic address: jknierim@jhu.edu
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Snippet	Granule cells in the dentate gyrus of the hippocampus are thought to be essential to memory function by decorrelating overlapping input patterns (pattern...
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SubjectTerms	Action Potentials - physiology Animals Brain Mapping CA3 Region, Hippocampal - cytology CA3 Region, Hippocampal - physiology Decision Trees Dentate Gyrus - cytology Dentate Gyrus - physiology Exploratory Behavior - physiology Interneurons - cytology Interneurons - physiology Memory Models, Neurological Mossy Fibers, Hippocampal - physiology Neurons - cytology Neurons - physiology Pyramidal Cells - cytology Pyramidal Cells - physiology Rats Rats, Long-Evans Spatial Processing - physiology
Title	Spatial Representations of Granule Cells and Mossy Cells of the Dentate Gyrus
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