Endothelial NADPH oxidase 4 protects ApoE-/- mice from atherosclerotic lesions

Vascular reactive oxygen species (ROS) are known to be involved in atherosclerosis development and progression. NADPH oxidase 4 (Nox4) is a constitutively active ROS-producing enzyme that is highly expressed in the vascular endothelium. Nox4 is unique in its biology and has been implicated in vascul...

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Bibliographic Details
Published in:	Free radical biology & medicine Vol. 89; pp. 1 - 7
Main Authors:	Craige, Siobhan M., Kant, Shashi, Reif, Michaella, Chen, Kai, Pei, Yongmei, Angoff, Rebecca, Sugamura, Koichi, Fitzgibbons, Timothy, Keaney, John F.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.12.2015
Subjects:	Animals Aorta - cytology Aorta - metabolism Apolipoproteins E - physiology Atherosclerosis Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - pathology Atherosclerosis - prevention & control Blotting, Western Cell Proliferation Cells, Cultured CXCL9 Cytokines - blood Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Female Humans Immunoenzyme Techniques Interferon-gamma - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic NADPH Oxidase 4 NADPH Oxidases - genetics NADPH Oxidases - metabolism Oxidative Stress Reactive oxygen species Reactive Oxygen Species - metabolism Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics T regulatory cells T-Lymphocytes, Regulatory - metabolism Reactive oxygen species CXCL9 NADPH Oxidase 4 T regulatory cells Atherosclerosis
ISSN:	0891-5849, 1873-4596, 1873-4596
Online Access:	Get full text
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