The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses

HLA class I (HLA-I) glycoproteins drive immune responses by presenting antigens to cognate CD8 T cells. This process is often hijacked by tumors and pathogens for immune evasion. Because options for restoring HLA-I antigen presentation are limited, we aimed to identify druggable HLA-I pathway target...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Jg. 54; H. 1; S. 132
Hauptverfasser:	Jongsma, Marlieke L M, de Waard, Antonius A, Raaben, Matthijs, Zhang, Tao, Cabukusta, Birol, Platzer, René, Blomen, Vincent A, Xagara, Anastasia, Verkerk, Tamara, Bliss, Sophie, Kong, Xiangrui, Gerke, Carolin, Janssen, Lennert, Stickel, Elmer, Holst, Stephanie, Plomp, Rosina, Mulder, Arend, Ferrone, Soldano, Claas, Frans H J, Heemskerk, Mirjam H M, Griffioen, Marieke, Halenius, Anne, Overkleeft, Hermen, Huppa, Johannes B, Wuhrer, Manfred, Brummelkamp, Thijn R, Neefjes, Jacques, Spaapen, Robbert M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 12.01.2021
Schlagworte:	Antigen Presentation Aspartic Acid Endopeptidases - genetics Aspartic Acid Endopeptidases - metabolism CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Glioma - immunology Glioma - mortality Glycosphingolipids - immunology Glycosphingolipids - metabolism Glycosyltransferases - metabolism Histocompatibility Antigens Class I - immunology Histocompatibility Antigens Class I - metabolism HLA Antigens - immunology HLA Antigens - metabolism Humans Immunotherapy - methods Lymphocyte Activation Signal Transduction Survival Analysis Tumor Escape antigen presentation immune recognition B3GNT5 glycosphingolipids immunotherapy HLA class I MHC class I glioma T cells SPPL3
ISSN:	1097-4180, 1097-4180
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