Association of physical activity with risk of chronic kidney disease in China: A population-based cohort study

•Total physical activity was inversely associated with the risk of chronic kidney disease (CKD).•Nonoccupational physical activity was inversely associated with the risk of CKD.•Both low-intensity and moderate- to vigorous-intensity physical activity were inversely associated with the risk of CKD.•P...

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Published in:Journal of sport and health science Vol. 13; no. 2; pp. 204 - 211
Main Authors: Shi, Kexiang, Zhu, Yunqing, Lv, Jun, Sun, Dianjianyi, Pei, Pei, Du, Huaidong, Chen, Yiping, Yang, Ling, Han, Bing, Stevens, Rebecca, Chen, Junshi, Chen, Zhengming, Li, Liming, Yu, Canqing
Format: Journal Article
Language:English
Published: China Elsevier B.V 01.03.2024
Key Laboratory of Epidemiology of Major Diseases(Peking University),Ministry of Education,Beijing 100191,China%Peking University Center for Public Health and Epidemic Preparedness & Response,Beijing 100191,China%Clinical Trial Service Unit & Epidemiological Studies Unit(CTSU),Nuffield Department of Population Health,University of Oxford,Oxford OX3 7LF,UK
Peking University Center for Public Health and Epidemic Preparedness & Response,Beijing 100191,China
Medical Research Council Population Health Research Unit at the University of Oxford,Oxford OX3 7LF,UK%NCDs Prevention and Control Department,Henan Center for Disease Control and Prevention,Zhengzhou 450016,China%Clinical Trial Service Unit & Epidemiological Studies Unit(CTSU),Nuffield Department of Population Health,University of Oxford,Oxford OX3 7LF,UK%China National Center for Food Safety Risk Assessment,Beijing 100022,China
Department of Epidemiology & Biostatistics,School of Public Health,Peking University Health Science Center,Beijing 100191,China%Department of Epidemiology & Biostatistics,School of Public Health,Peking University Health Science Center,Beijing 100191,China
Shanghai University of Sport
Elsevier
Subjects:
Adult
Chronic kidney disease
Cohort Studies
Domain
Exercise
Humans
Hypertension, Renal
Incidence
Intensity
Nephritis
Original
Physical activity
Renal Insufficiency, Chronic - epidemiology
Chronic kidney disease
Physical activity
Domain
Intensity
ISSN:2095-2546, 2213-2961, 2213-2961
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Summary:•Total physical activity was inversely associated with the risk of chronic kidney disease (CKD).•Nonoccupational physical activity was inversely associated with the risk of CKD.•Both low-intensity and moderate- to vigorous-intensity physical activity were inversely associated with the risk of CKD.•Physical activity could be a target for intervention in CKD, no matter what type or intensity. Information on the association between physical activity (PA) and the risk of chronic kidney disease (CKD) is limited. We aimed to explore the associations of total, domain-specific, and intensity-specific PA with CKD and its subtypes in China. The study included 475,376 adults from the China Kadoorie Biobank aged 30–79 years during 2004–2008 at baseline. An interviewer-administered questionnaire was used to collect the information about PA, which was quantified as metabolic equivalent of task hours per day (MET-h/day) and categorized into 4 groups based on quartiles. Cox regression was used to analyze the association between PA and CKD risk. During a median follow-up of 12.1 years, 5415 incident CKD cases were documented, including 1159 incident diabetic kidney disease (DKD) cases and 362 incident hypertensive nephropathy (HTN) cases. Total PA was inversely associated with CKD risk, with an adjusted hazard ratio (HR, 95% confidence interval (95%CI)) of 0.83 (0.75–0.92) for incident CKD in the highest quartile of total PA as compared with participants in the lowest quartile. Similar results were observed for risk of DKD and HTN, and the corresponding HRs (95%CIs) were 0.75 (0.58–0.97) for DKD risk and 0.56 (0.37–0.85) for HTN risk. Increased nonoccupational PA, low-intensity PA, and moderate-to-vigorous-intensity PA were significantly associated with a decreased risk of CKD, with HRs (95%CIs) of 0.80 (0.73–0.88), 0.85 (0.77–0.94), and 0.85 (0.76–0.95) in the highest quartile, respectively. PA, including nonoccupational PA, low-intensity PA, and moderate-to-vigorous-intensity PA, was inversely associated with the risk of CKD, including DKD, HTN, and other CKD, and such associations were dose dependent. [Display omitted]
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The members of the steering committee and collaborative group are listed in the online-only supplementary materials.
ISSN:2095-2546
2213-2961
2213-2961
DOI:10.1016/j.jshs.2023.07.004