Specific alterations of regional myocardial work in strength-trained athletes using anabolic androgenic steroids compared to athletes with genetic hypertrophic cardiomyopathy

•Athletes who use steroids or are diagnosed with CMH have LV regional dysfunctions.•The anabolic steroids used by athletes induce a drop in myocardial work efficiency.•Regional myocardial work analysis differentiates between steroid use and CMH in athletes. Strength-trained athletes using anabolic a...

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Vydáno v:Journal of sport and health science Ročník 12; číslo 4; s. 477 - 485
Hlavní autoři: Grandperrin, Antoine, Schnell, Frédéric, Donal, Erwan, Galli, Elena, Hedon, Christophe, Cazorla, Olivier, Nottin, Stéphane
Médium: Journal Article
Jazyk:angličtina
Vydáno: China Elsevier B.V 01.07.2023
Avignon University,LaPEC UPR 4278,Avignon F-84000,France%Rennes University,CHU Rennes,Inserm,LTSI-UMR 1099,Rennes F-35000,France%Montpellier University,PhyMedExp,INSERM,CNRS,Physiology and Experimental Heart and Muscle Medicine,Montpellier 34295,France
Shanghai University of Sport
Elsevier
Témata:
Anabolic androgenic steroids
Hypertrophic cardiomyopathy
Left ventricular function
Myocardial work
Original
Speckle-tracking echocardiography
Anabolic androgenic steroids
Hypertrophic cardiomyopathy
Speckle-tracking echocardiography
Myocardial work
Left ventricular function
ISSN:2095-2546, 2213-2961, 2213-2961
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Shrnutí:•Athletes who use steroids or are diagnosed with CMH have LV regional dysfunctions.•The anabolic steroids used by athletes induce a drop in myocardial work efficiency.•Regional myocardial work analysis differentiates between steroid use and CMH in athletes. Strength-trained athletes using anabolic androgenic steroids (AAS) have left ventricular (LV) hypertrophy and myocardial fibrosis that can lead to sudden cardiac death. A similar feature was described in athletes with hypertrophic cardiomyopathy (HCM), which complicates the diagnosis for clinicians. In this context, we aimed to compare the LV function of the 2 populations by measuring global and regional strain and myocardial work using speckle-tracking imaging. Twenty-four strength-trained asymptomatic athletes using AAS (AAS-Athletes), 22 athletes diagnosed with HCM (HCM-Athletes), and 20 healthy control athletes (Ctrl-Athletes) underwent a resting echocardiography to assess LV function. We evaluated LV global and regional strains and myocardial work, with an evaluation of the constructive work (CW), wasted work, and work efficiency (WE). Compared to Ctrl-Athletes, both AAS-Athletes and HCM-Athletes had a thicker interventricular septum, with majored values in HCM-Athletes. LV strain was reduced in AAS-Athletes and even more in HCM-Athletes. Consequently, global WE was significantly diminished in both AAS and HCM-Athletes (93% ± 2% in Ctrl-Athletes, 90% ± 4% in AAS-Athletes, and 90% ± 5% in HCM-Athletes (mean ± SD); p < 0.05). Constructive work and WE regional analysis showed specific alterations, with the basal septal segments preferentially affected in AAS-Athletes, and both septal and apical segments affected in HCM-Athletes. The regional evaluation of myocardial work reported specific alterations of the major LV hypertrophy induced by the regular use of AAS compared to the LV hypertrophy due to HCM. This finding could help clinicians to differentiate between these 2 forms of pathological hypertrophy. [Display omitted]
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:2095-2546
2213-2961
2213-2961
DOI:10.1016/j.jshs.2022.07.004