Autophagy in major human diseases

Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy‐related processes cause s...

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Published in:	The EMBO journal Vol. 40; no. 19; pp. e108863 - n/a
Main Authors:	Klionsky, Daniel J, Petroni, Giulia, Amaravadi, Ravi K, Baehrecke, Eric H, Ballabio, Andrea, Boya, Patricia, Bravo‐San Pedro, José Manuel, Cadwell, Ken, Cecconi, Francesco, Choi, Augustine M K, Choi, Mary E, Chu, Charleen T, Codogno, Patrice, Colombo, Maria Isabel, Cuervo, Ana Maria, Deretic, Vojo, Dikic, Ivan, Elazar, Zvulun, Eskelinen, Eeva‐Liisa, Fimia, Gian Maria, Gewirtz, David A, Green, Douglas R, Hansen, Malene, Jäättelä, Marja, Johansen, Terje, Juhász, Gábor, Karantza, Vassiliki, Kraft, Claudine, Kroemer, Guido, Ktistakis, Nicholas T, Kumar, Sharad, Lopez‐Otin, Carlos, Macleod, Kay F, Madeo, Frank, Martinez, Jennifer, Meléndez, Alicia, Mizushima, Noboru, Münz, Christian, Penninger, Josef M, Perera, Rushika M, Piacentini, Mauro, Reggiori, Fulvio, Rubinsztein, David C, Ryan, Kevin M, Sadoshima, Junichi, Santambrogio, Laura, Scorrano, Luca, Simon, Hans‐Uwe, Simon, Anna Katharina, Simonsen, Anne, Stolz, Alexandra, Tavernarakis, Nektarios, Tooze, Sharon A, Yoshimori, Tamotsu, Yuan, Junying, Yue, Zhenyu, Zhong, Qing, Galluzzi, Lorenzo, Pietrocola, Federico
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.10.2021 Springer Nature B.V John Wiley and Sons Inc
Subjects:	aging Animals Autophagy Autophagy - drug effects Autophagy - genetics Autophagy - immunology Biomarkers cancer Disease Susceptibility Disorders EMBO07 Eye disorders Gene Expression Regulation Genetic Predisposition to Disease Homeostasis Host-Pathogen Interactions Humans inflammation metabolic syndromes Mutation neurodegeneration Organ Specificity Pathogenesis Phagocytosis Review Signal Transduction neurodegeneration cancer metabolic syndromes aging inflammation
ISSN:	0261-4189, 1460-2075, 1460-2075
Online Access:	Get full text
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