Autophagy in major human diseases

Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy‐related processes cause s...

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Bibliographic Details
Published in:The EMBO journal Vol. 40; no. 19; pp. e108863 - n/a
Main Authors: Klionsky, Daniel J, Petroni, Giulia, Amaravadi, Ravi K, Baehrecke, Eric H, Ballabio, Andrea, Boya, Patricia, Bravo‐San Pedro, José Manuel, Cadwell, Ken, Cecconi, Francesco, Choi, Augustine M K, Choi, Mary E, Chu, Charleen T, Codogno, Patrice, Colombo, Maria Isabel, Cuervo, Ana Maria, Deretic, Vojo, Dikic, Ivan, Elazar, Zvulun, Eskelinen, Eeva‐Liisa, Fimia, Gian Maria, Gewirtz, David A, Green, Douglas R, Hansen, Malene, Jäättelä, Marja, Johansen, Terje, Juhász, Gábor, Karantza, Vassiliki, Kraft, Claudine, Kroemer, Guido, Ktistakis, Nicholas T, Kumar, Sharad, Lopez‐Otin, Carlos, Macleod, Kay F, Madeo, Frank, Martinez, Jennifer, Meléndez, Alicia, Mizushima, Noboru, Münz, Christian, Penninger, Josef M, Perera, Rushika M, Piacentini, Mauro, Reggiori, Fulvio, Rubinsztein, David C, Ryan, Kevin M, Sadoshima, Junichi, Santambrogio, Laura, Scorrano, Luca, Simon, Hans‐Uwe, Simon, Anna Katharina, Simonsen, Anne, Stolz, Alexandra, Tavernarakis, Nektarios, Tooze, Sharon A, Yoshimori, Tamotsu, Yuan, Junying, Yue, Zhenyu, Zhong, Qing, Galluzzi, Lorenzo, Pietrocola, Federico
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 01.10.2021
Springer Nature B.V
John Wiley and Sons Inc
Subjects:
aging
Animals
Autophagy
Autophagy - drug effects
Autophagy - genetics
Autophagy - immunology
Biomarkers
cancer
Disease Susceptibility
Disorders
EMBO07
Eye disorders
Gene Expression Regulation
Genetic Predisposition to Disease
Homeostasis
Host-Pathogen Interactions
Humans
inflammation
metabolic syndromes
Mutation
neurodegeneration
Organ Specificity
Pathogenesis
Phagocytosis
Review
Signal Transduction
neurodegeneration
cancer
metabolic syndromes
aging
inflammation
ISSN:0261-4189, 1460-2075, 1460-2075
Online Access:Get full text
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Summary:Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy‐related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders. Graphical Abstract This review provides an exhaustive overview of the contribution of autophagy to multiple pathological phenotypes in vivo , and discusses the therapeutic potential of autophagy modulation in disease prevention and treatment.
Bibliography:See the Glossary for abbreviations used in this article.
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ISSN:0261-4189
1460-2075
1460-2075
DOI:10.15252/embj.2021108863