Role of adipose tissue in haemostasis, coagulation and fibrinolysis

Obesity is associated with an increased incidence of insulin resistance (IR), type 2 diabetes mellitus and cardiovascular diseases. The increased risk for cardiovascular diseases could partly be caused by a prothrombotic state that exists because of abdominal obesity. Adipose tissue induces thromboc...

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Vydáno v:Obesity reviews Ročník 10; číslo 5; s. 554 - 563
Hlavní autoři: Faber, D.R, de Groot, Ph.G, Visseren, F.L.J
Médium: Journal Article
Jazyk:angličtina
Vydáno: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.09.2009
Blackwell Publishing Ltd
Témata:
adiponectin
Adipose tissue
Adipose Tissue - physiology
Animals
blood platelets
Blood Platelets - physiology
cardiovascular diseases
coagulation
factor VII
factor VIII
fibrinogen
fibrinolysis
Fibrinolysis - physiology
free fatty acids
haemostasis
hemostasis
Humans
inflammation
insulin resistance
interleukin-1beta
interleukin-6
leptin
Liver
Liver - physiology
neoplasms
noninsulin-dependent diabetes mellitus
obesity
physiology
plasminogen activator inhibitors
risk
tumor necrosis factor-alpha
ISSN:1467-7881, 1467-789X, 1467-789X
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Shrnutí:Obesity is associated with an increased incidence of insulin resistance (IR), type 2 diabetes mellitus and cardiovascular diseases. The increased risk for cardiovascular diseases could partly be caused by a prothrombotic state that exists because of abdominal obesity. Adipose tissue induces thrombocyte activation by the production of adipose tissue-derived hormones, often called adipokines, of which some such as leptin and adiponectin have been shown to directly interfere with platelet function. Increased adipose tissue mass induces IR and systemic low-grade inflammation, also affecting platelet function. It has been demonstrated that adipose tissue directly impairs fibrinolysis by the production of plasminogen activator inhibitor-1 and possibly thrombin-activatable fibrinolysis inhibitor. Adipose tissue may contribute to enhanced coagulation by direct tissue factor production, but hypercoagulability is likely to be primarily caused by affecting hepatic synthesis of the coagulation factors fibrinogen, factor VII, factor VIII and tissue factor, by releasing free fatty acids and pro-inflammatory cytokines (tumour necrosis factor-α, interleukin-1β and interleukin-6) into the portal circulation and by inducing hepatic IR. Adipose tissue dysfunction could thus play a causal role in the prothrombotic state observed in obesity, by directly and indirectly affecting haemostasis, coagulation and fibrinolysis.
Bibliografie:http://dx.doi.org/10.1111/j.1467-789X.2009.00593.x
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ArticleID:OBR593
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ISSN:1467-7881
1467-789X
1467-789X
DOI:10.1111/j.1467-789X.2009.00593.x