Neurocognitive mechanisms of anxiety: an integrative account

Anxiety can be hugely disruptive to everyday life. Anxious individuals show increased attentional capture by potential signs of danger, and interpret expressions, comments and events in a negative manner. These cognitive biases have been widely explored in human anxiety research. By contrast, animal...

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Vydané v:	Trends in cognitive sciences Ročník 11; číslo 7; s. 307 - 316
Hlavný autor:	Bishop, Sonia J.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Elsevier Ltd 01.07.2007 Elsevier
Predmet:	Affectivity. Emotion Amygdala - physiopathology Anatomical correlates of behavior Animals Anxiety Disorders - physiopathology Arousal - physiology Attention - physiology Behavioral psychophysiology Biological and medical sciences Brain - physiopathology Brain Mapping Conditioning, Classical - physiology Desensitization, Psychologic Extinction, Psychological - physiology Fear - physiology Frontal Lobe - physiology Fundamental and applied biological sciences. Psychology Gyrus Cinguli - physiopathology Hippocampus - physiology Humans Imaging, Three-Dimensional Nerve Net - physiopathology Neurology Personality. Affectivity Prefrontal Cortex - physiopathology Psychiatry Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Social Perception Temporal Lobe - physiopathology Visual Cortex - physiopathology Visual Perception - physiology Human Affect affectivity Animal model Central nervous system Anxiety Cognition Review Encephalon
ISSN:	1364-6613, 1879-307X
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Shrnutí:	Anxiety can be hugely disruptive to everyday life. Anxious individuals show increased attentional capture by potential signs of danger, and interpret expressions, comments and events in a negative manner. These cognitive biases have been widely explored in human anxiety research. By contrast, animal models have focused upon the mechanisms underlying acquisition and extinction of conditioned fear, guiding exposure-based therapies for anxiety disorders. Recent neuroimaging studies of conditioned fear, attention to threat and interpretation of emotionally ambiguous stimuli indicate common amygdala–prefrontal circuitry underlying these processes, and suggest that the balance of activity within this circuitry is altered in anxiety, creating a bias towards threat-related responses. This provides a focus for future translational research, and targeted pharmacological and cognitive interventions.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1364-6613 1879-307X
DOI:	10.1016/j.tics.2007.05.008