Neurocognitive mechanisms of anxiety: an integrative account

Anxiety can be hugely disruptive to everyday life. Anxious individuals show increased attentional capture by potential signs of danger, and interpret expressions, comments and events in a negative manner. These cognitive biases have been widely explored in human anxiety research. By contrast, animal...

Full description

Saved in:
Bibliographic Details
Published in:Trends in cognitive sciences Vol. 11; no. 7; pp. 307 - 316
Main Author: Bishop, Sonia J.
Format: Journal Article
Language:English
Published: London Elsevier Ltd 01.07.2007
Elsevier
Subjects:
Affectivity. Emotion
Amygdala - physiopathology
Anatomical correlates of behavior
Animals
Anxiety Disorders - physiopathology
Arousal - physiology
Attention - physiology
Behavioral psychophysiology
Biological and medical sciences
Brain - physiopathology
Brain Mapping
Conditioning, Classical - physiology
Desensitization, Psychologic
Extinction, Psychological - physiology
Fear - physiology
Frontal Lobe - physiology
Fundamental and applied biological sciences. Psychology
Gyrus Cinguli - physiopathology
Hippocampus - physiology
Humans
Imaging, Three-Dimensional
Nerve Net - physiopathology
Neurology
Personality. Affectivity
Prefrontal Cortex - physiopathology
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Social Perception
Temporal Lobe - physiopathology
Visual Cortex - physiopathology
Visual Perception - physiology
Human
Affect affectivity
Animal model
Central nervous system
Anxiety
Cognition
Review
Encephalon
ISSN:1364-6613, 1879-307X
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Anxiety can be hugely disruptive to everyday life. Anxious individuals show increased attentional capture by potential signs of danger, and interpret expressions, comments and events in a negative manner. These cognitive biases have been widely explored in human anxiety research. By contrast, animal models have focused upon the mechanisms underlying acquisition and extinction of conditioned fear, guiding exposure-based therapies for anxiety disorders. Recent neuroimaging studies of conditioned fear, attention to threat and interpretation of emotionally ambiguous stimuli indicate common amygdala–prefrontal circuitry underlying these processes, and suggest that the balance of activity within this circuitry is altered in anxiety, creating a bias towards threat-related responses. This provides a focus for future translational research, and targeted pharmacological and cognitive interventions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1364-6613
1879-307X
DOI:10.1016/j.tics.2007.05.008