Asymptomatic Cerebral Small Vessel Disease: Insights from Population-Based Studies

Cerebral small vessel disease (CSVD) is a common group of neurological conditions that confer a significant burden of morbidity and mortality worldwide. In most cases, CSVD is only recognized in its advanced stages once its symptomatic sequelae develop. However, its significance in asymptomatic heal...

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Published in:Journal of stroke Vol. 21; no. 2; pp. 121 - 138
Main Authors: Das, Alvin S., Regenhardt, Robert W., Vernooij, Meike W., Blacker, Deborah, Charidimou, Andreas, Viswanathan, Anand
Format: Journal Article
Language:English
Published: Korea (South) Korean Stroke Society 01.05.2019
대한뇌졸중학회
Subjects:
cerebral small vessel diseases
epidemiology
leukoaraiosis
Review
stroke, lacunar
신경과학
Stroke, lacunar
Cerebral small vessel diseases
Epidemiology
Leukoaraiosis
ISSN:2287-6391, 1229-4101, 2287-6405
Online Access:Get full text
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Summary:Cerebral small vessel disease (CSVD) is a common group of neurological conditions that confer a significant burden of morbidity and mortality worldwide. In most cases, CSVD is only recognized in its advanced stages once its symptomatic sequelae develop. However, its significance in asymptomatic healthy populations remains poorly defined. In population-based studies of presumed healthy elderly individuals, CSVD neuroimaging markers including white matter hyperintensities, lacunes, cerebral microbleeds, enlarged perivascular spaces, cortical superficial siderosis, and cerebral microinfarcts are frequently detected. While the presence of these imaging markers may reflect unique mechanisms at play, there are likely shared pathways underlying CSVD. Herein, we aim to assess the etiology and significance of these individual biomarkers by focusing in asymptomatic populations at an epidemiological level. By primarily examining population-based studies, we explore the risk factors that are involved in the formation and progression of these biomarkers. Through a critical semi-systematic review, we aim to characterize "asymptomatic" CSVD, review screening modalities, and draw associations from observational studies in clinical populations. Lastly, we highlight areas of research (including therapeutic approaches) in which further investigation is needed to better understand asymptomatic CSVD.
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ISSN:2287-6391
1229-4101
2287-6405
DOI:10.5853/jos.2018.03608