Type, rather than number, of mental and physical comorbidities increases the severity of symptoms in patients with irritable bowel syndrome
Irritable bowel syndrome (IBS) has significant mental and physical comorbidities. However, little is known about the day-to-day burden these comorbidities place on quality of life (QOL), physical and mental function, distress, and symptoms of patients. We collected cross-sectional data from 175 pati...
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| Vydáno v: | Clinical gastroenterology and hepatology Ročník 11; číslo 9; s. 1147 |
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| Hlavní autoři: | , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
01.09.2013
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| ISSN: | 1542-7714, 1542-7714 |
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| Abstract | Irritable bowel syndrome (IBS) has significant mental and physical comorbidities. However, little is known about the day-to-day burden these comorbidities place on quality of life (QOL), physical and mental function, distress, and symptoms of patients.
We collected cross-sectional data from 175 patients with IBS, which was diagnosed on the basis of Rome III criteria (median age, 41 years; 78% women), who were referred to 2 specialty care clinics. Patients completed psychiatric interviews, a physical comorbidity checklist, the IBS Symptom Severity Scale, the IBS-QOL instrument, the Brief Symptom Inventory, the abdominal pain intensity scale, and the Short Form-12 Health Survey.
Patients with IBS reported an average of 5 comorbidities (1 mental, 4 physical). Subjects with more comorbidities reported worse QOL after adjusting for confounding variables. Multiple linear regression analyses indicated that comorbidity type was more consistently and strongly associated with illness burden indicators than disease counts. Of 10,296 possible physical-mental comorbidity pairs, 6 of the 10 most frequent dyads involved specific conditions (generalized anxiety, depression, back pain, agoraphobia, tension headache, and insomnia). These combinations were consistently associated with greater illness and symptom burdens (QOL, mental and physical function, distress, more severe symptoms of IBS, and pain).
Comorbidities are common among patients with IBS. They are associated with distress and reduced QOL. Specific comorbidities are associated with more severe symptoms of IBS. |
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| AbstractList | Irritable bowel syndrome (IBS) has significant mental and physical comorbidities. However, little is known about the day-to-day burden these comorbidities place on quality of life (QOL), physical and mental function, distress, and symptoms of patients.BACKGROUND & AIMSIrritable bowel syndrome (IBS) has significant mental and physical comorbidities. However, little is known about the day-to-day burden these comorbidities place on quality of life (QOL), physical and mental function, distress, and symptoms of patients.We collected cross-sectional data from 175 patients with IBS, which was diagnosed on the basis of Rome III criteria (median age, 41 years; 78% women), who were referred to 2 specialty care clinics. Patients completed psychiatric interviews, a physical comorbidity checklist, the IBS Symptom Severity Scale, the IBS-QOL instrument, the Brief Symptom Inventory, the abdominal pain intensity scale, and the Short Form-12 Health Survey.METHODSWe collected cross-sectional data from 175 patients with IBS, which was diagnosed on the basis of Rome III criteria (median age, 41 years; 78% women), who were referred to 2 specialty care clinics. Patients completed psychiatric interviews, a physical comorbidity checklist, the IBS Symptom Severity Scale, the IBS-QOL instrument, the Brief Symptom Inventory, the abdominal pain intensity scale, and the Short Form-12 Health Survey.Patients with IBS reported an average of 5 comorbidities (1 mental, 4 physical). Subjects with more comorbidities reported worse QOL after adjusting for confounding variables. Multiple linear regression analyses indicated that comorbidity type was more consistently and strongly associated with illness burden indicators than disease counts. Of 10,296 possible physical-mental comorbidity pairs, 6 of the 10 most frequent dyads involved specific conditions (generalized anxiety, depression, back pain, agoraphobia, tension headache, and insomnia). These combinations were consistently associated with greater illness and symptom burdens (QOL, mental and physical function, distress, more severe symptoms of IBS, and pain).RESULTSPatients with IBS reported an average of 5 comorbidities (1 mental, 4 physical). Subjects with more comorbidities reported worse QOL after adjusting for confounding variables. Multiple linear regression analyses indicated that comorbidity type was more consistently and strongly associated with illness burden indicators than disease counts. Of 10,296 possible physical-mental comorbidity pairs, 6 of the 10 most frequent dyads involved specific conditions (generalized anxiety, depression, back pain, agoraphobia, tension headache, and insomnia). These combinations were consistently associated with greater illness and symptom burdens (QOL, mental and physical function, distress, more severe symptoms of IBS, and pain).Comorbidities are common among patients with IBS. They are associated with distress and reduced QOL. Specific comorbidities are associated with more severe symptoms of IBS.CONCLUSIONSComorbidities are common among patients with IBS. They are associated with distress and reduced QOL. Specific comorbidities are associated with more severe symptoms of IBS. Irritable bowel syndrome (IBS) has significant mental and physical comorbidities. However, little is known about the day-to-day burden these comorbidities place on quality of life (QOL), physical and mental function, distress, and symptoms of patients. We collected cross-sectional data from 175 patients with IBS, which was diagnosed on the basis of Rome III criteria (median age, 41 years; 78% women), who were referred to 2 specialty care clinics. Patients completed psychiatric interviews, a physical comorbidity checklist, the IBS Symptom Severity Scale, the IBS-QOL instrument, the Brief Symptom Inventory, the abdominal pain intensity scale, and the Short Form-12 Health Survey. Patients with IBS reported an average of 5 comorbidities (1 mental, 4 physical). Subjects with more comorbidities reported worse QOL after adjusting for confounding variables. Multiple linear regression analyses indicated that comorbidity type was more consistently and strongly associated with illness burden indicators than disease counts. Of 10,296 possible physical-mental comorbidity pairs, 6 of the 10 most frequent dyads involved specific conditions (generalized anxiety, depression, back pain, agoraphobia, tension headache, and insomnia). These combinations were consistently associated with greater illness and symptom burdens (QOL, mental and physical function, distress, more severe symptoms of IBS, and pain). Comorbidities are common among patients with IBS. They are associated with distress and reduced QOL. Specific comorbidities are associated with more severe symptoms of IBS. |
| Author | Sitrin, Michael D Satchidanand, Nikhil Lackner, Jeffrey M Keefer, Laurie Ballou, Sarah K Krasner, Susan S Ma, Chang-Xing Katz, Leonard Naliboff, Bruce D Brenner, Darren M Gudleski, Gregory D Firth, Rebecca Mayer, Emeran A |
| Author_xml | – sequence: 1 givenname: Jeffrey M surname: Lackner fullname: Lackner, Jeffrey M email: lackner@buffalo.edu organization: Department of Medicine, University at Buffalo School of Medicine, SUNY, Buffalo, New York 14215, USA. lackner@buffalo.edu – sequence: 2 givenname: Chang-Xing surname: Ma fullname: Ma, Chang-Xing – sequence: 3 givenname: Laurie surname: Keefer fullname: Keefer, Laurie – sequence: 4 givenname: Darren M surname: Brenner fullname: Brenner, Darren M – sequence: 5 givenname: Gregory D surname: Gudleski fullname: Gudleski, Gregory D – sequence: 6 givenname: Nikhil surname: Satchidanand fullname: Satchidanand, Nikhil – sequence: 7 givenname: Rebecca surname: Firth fullname: Firth, Rebecca – sequence: 8 givenname: Michael D surname: Sitrin fullname: Sitrin, Michael D – sequence: 9 givenname: Leonard surname: Katz fullname: Katz, Leonard – sequence: 10 givenname: Susan S surname: Krasner fullname: Krasner, Susan S – sequence: 11 givenname: Sarah K surname: Ballou fullname: Ballou, Sarah K – sequence: 12 givenname: Bruce D surname: Naliboff fullname: Naliboff, Bruce D – sequence: 13 givenname: Emeran A surname: Mayer fullname: Mayer, Emeran A |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23524278$$D View this record in MEDLINE/PubMed |
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| Keywords | PCS Irritable Bowel Syndrome Outcome Study low back pain global severity index Irritable Bowel Syndrome Symptom Severity Scale National Institutes of Health MDD MINI International Neuropsychiatric Interview generalized anxiety disorder major depression disorder BSI Transdiagnostic Mental Functioning IBS LBP GSI IBSOS DSM Diagnostic and Statistical Manual of Mental Disorders GI Brief Symptom Inventory Comorbidity irritable bowel syndrome SF-12 12-item Short Form GAD NIH Health-Related Quality of Life IBS-SSS Stress QOL gastrointestinal GERD MINI HRQOL SF-12 Physical Component Score MCS quality of life Chronic Disease SF-12 Mental Component Score gastroesophageal reflux disease |
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| Snippet | Irritable bowel syndrome (IBS) has significant mental and physical comorbidities. However, little is known about the day-to-day burden these comorbidities... |
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| SubjectTerms | Abdominal Pain - complications Adolescent Adult Aged Comorbidity Cross-Sectional Studies Female Humans Irritable Bowel Syndrome - pathology Irritable Bowel Syndrome - psychology Male Mental Disorders - complications Middle Aged Quality of Life Severity of Illness Index Young Adult |
| Title | Type, rather than number, of mental and physical comorbidities increases the severity of symptoms in patients with irritable bowel syndrome |
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