Isolation of Madre de Dios Virus (Orthobunyavirus; Bunyaviridae), an Oropouche Virus Species Reassortant, from a Monkey in Venezuela

Oropouche virus (OROV), genus Orthobunyavirus, family Bunyaviridae, is an important cause of human illness in tropical South America. Herein, we report the isolation, complete genome sequence, genetic characterization, and phylogenetic analysis of an OROV species reassortant, Madre de Dios virus (MD...

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Bibliographic Details
Published in:The American journal of tropical medicine and hygiene Vol. 95; no. 2; pp. 328 - 338
Main Authors: Navarro, Juan-Carlos, Giambalvo, Dileyvic, Hernandez, Rosa, Auguste, Albert J, Tesh, Robert B, Weaver, Scott C, Montañez, Humberto, Liria, Jonathan, Lima, Anderson, Travassos da Rosa, Jorge Fernando Soares, da Silva, Sandro P, Vasconcelos, Janaina M, Oliveira, Rodrigo, Vianez, Jr, João L S G, Nunes, Marcio R T
Format: Journal Article
Language:English
Published: United States 03.08.2016
Subjects:
Animals
Bunyaviridae Infections - diagnosis
Bunyaviridae Infections - virology
Cebus - virology
Chlorocebus aethiops
Genome, Viral
High-Throughput Nucleotide Sequencing
Orthobunyavirus - classification
Orthobunyavirus - genetics
Orthobunyavirus - isolation & purification
Phylogeny
Reassortant Viruses - classification
Reassortant Viruses - genetics
Reassortant Viruses - isolation & purification
RNA, Viral - genetics
Venezuela
Vero Cells
Venezuela
ISSN:1476-1645
Online Access:Get more information
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Summary:Oropouche virus (OROV), genus Orthobunyavirus, family Bunyaviridae, is an important cause of human illness in tropical South America. Herein, we report the isolation, complete genome sequence, genetic characterization, and phylogenetic analysis of an OROV species reassortant, Madre de Dios virus (MDDV), obtained from a sick monkey (Cebus olivaceus Schomburgk) collected in a forest near Atapirire, a small rural village located in Anzoategui State, Venezuela. MDDV is one of a growing number of naturally occurring OROV species reassortants isolated in South America and was known previously only from southern Peru.
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ISSN:1476-1645
DOI:10.4269/ajtmh.15-0679