The placental renin–angiotensin system and oxidative stress in pre-eclampsia

There is an inverse correlation between human birthweight and umbilical venous angiotensin II (AngII) concentrations. Oxidative stress and increased pro-renin receptor (PRR) both enhance the cleavage of angiotensin I from angiotensinogen (AGT). Pre-eclampsia, a hypertensive disorder of pregnancy, ma...

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Veröffentlicht in:Placenta (Eastbourne) Jg. 34; H. 2; S. 182 - 186
Hauptverfasser: Mistry, H.D., Kurlak, L.O., Broughton Pipkin, F.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Kidlington Elsevier Ltd 01.02.2013
Elsevier
Schlagworte:
Angiotensin receptors
Angiotensinogen
Angiotensinogen - metabolism
Biological and medical sciences
Case-Control Studies
Embryology: invertebrates and vertebrates. Teratology
Female
Fundamental and applied biological sciences. Psychology
Glutathione Peroxidase - metabolism
Humans
Immunohistochemistry
Infant, Low Birth Weight
Infant, Newborn
Internal Medicine
Male
Obstetrics and Gynecology
Oxidative Stress
Placenta
Placenta - metabolism
Pre-eclampsia
Pre-Eclampsia - metabolism
Pregnancy
Pregnancy. Parturition. Lactation
Pro-renin receptor
Receptor, Angiotensin, Type 1 - metabolism
Receptor, Angiotensin, Type 2 - metabolism
Receptors, Cell Surface - metabolism
Renin-Angiotensin System - physiology
Renin–angiotensin system
Trophoblasts - metabolism
Vertebrates: reproduction
Renin–angiotensin system
Angiotensinogen
Pro-renin receptor
Placenta
Pre-eclampsia
Angiotensin receptors
Oxidative stress
Vertebrata
Renin angiotensin system
Mammalia
Pregnancy disorders
Fetal membrane
Preeclampsia
Pregnancy toxemia
ISSN:0143-4004, 1532-3102, 1532-3102
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Zusammenfassung:There is an inverse correlation between human birthweight and umbilical venous angiotensin II (AngII) concentrations. Oxidative stress and increased pro-renin receptor (PRR) both enhance the cleavage of angiotensin I from angiotensinogen (AGT). Pre-eclampsia, a hypertensive disorder of pregnancy, manifests as high blood pressure and proteinuria, and is a state of increased oxidative stress. Hypothesis: Pre-eclampsia will be associated with increased placental expression of components of the renin–angiotensin system, which could result in reduced infant birthweight. Biopsies were taken 1 cm from the placental edge from 27 normotensive controls and 23 pre-eclamptic White European women. Immunohistochemistry was performed for AGT, PRR, glutathione peroxidase 3 (GPx3) and the AT1R and AT2R AngII receptors. Protein expression was semi-quantitatively assessed (H-score). AT1R expression was significantly increased in pre-eclamptic placentae, and negatively correlated with birthweight (r = −0.529, P = 0.009). AT1R expression was also negatively correlated with GPx3 expression overall (r = −0.647; P = 0.005). AT2R expression positively correlated with AGT (r = 0.615, P = 0.002) in the pre-eclamptic placentae only. The raised AT1R expression in pre-eclampsia, together with inadequate antioxidant protection, possibly through lower GPx activity, might enhance the vasoconstrictor effect of locally-generated AngII, contributing to the restricted fetal growth characteristic of pre-eclampsia. Conversely, the AT2R:AGT association within the pre-eclamptic placenta may provide a compensatory mechanism.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0143-4004
1532-3102
1532-3102
DOI:10.1016/j.placenta.2012.11.027