Expression of voltage-dependent potassium channels in first trimester human placentae

Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (KV7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental...

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Vydané v:	Placenta (Eastbourne) Ročník 35; číslo 5; s. 337 - 340
Hlavní autori:	Mistry, H.D., Kurlak, L.O., Whitley, G.S., Cartwright, J.E., Broughton Pipkin, F., Tribe, R.M.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Kidlington Elsevier Ltd 01.05.2014 Elsevier
Predmet:	Adult Biological and medical sciences Early pregnancy Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Humans Internal Medicine KCNE KCNQ Obstetrics and Gynecology Placenta Placenta - metabolism Potassium channel Potassium Channels, Voltage-Gated - genetics Potassium Channels, Voltage-Gated - metabolism Pregnancy Pregnancy Trimester, First - genetics Pregnancy Trimester, First - metabolism KCNQ Early pregnancy Placenta KCNE Potassium channel Pregnancy Human Vertebrata Mammalia First trimester Ionic channel Inorganic element Potassium
ISSN:	0143-4004, 1532-3102, 1532-3102
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Abstract	Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (KV7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental tissue. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at ≤10 weeks' (early TOP) and >10 weeks' (mid TOP) gestations. KCNQ1-5 expression was unchanged during the first trimester. KCNE5 expression increased in mid TOP vs. early TOP samples (P = 0.022). This novel study reports mRNA and protein expression of KV7 channels in first trimester placentae.
AbstractList	Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (KV7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental tissue. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at ≤10 weeks' (early TOP) and >10 weeks' (mid TOP) gestations. KCNQ1-5 expression was unchanged during the first trimester. KCNE5 expression increased in mid TOP vs. early TOP samples (P = 0.022). This novel study reports mRNA and protein expression of KV7 channels in first trimester placentae. Abstract Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (KV 7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental tissue. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at ≤10 weeks' (early TOP) and >10 weeks' (mid TOP) gestations. KCNQ1-5 expression was unchanged during the first trimester. KCNE5 expression increased in mid TOP vs. early TOP samples ( P = 0.022). This novel study reports mRNA and protein expression of KV 7 channels in first trimester placentae. Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (KV7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental tissue. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at ≤ 10 weeks' (early TOP) and >10 weeks' (mid TOP) gestations. KCNQ1-5 expression was unchanged during the first trimester. KCNE5 expression increased in mid TOP vs. early TOP samples (P = 0.022). This novel study reports mRNA and protein expression of KV7 channels in first trimester placentae. Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (KV7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental tissue. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at ≤ 10 weeks' (early TOP) and >10 weeks' (mid TOP) gestations. KCNQ1-5 expression was unchanged during the first trimester. KCNE5 expression increased in mid TOP vs. early TOP samples (P = 0.022). This novel study reports mRNA and protein expression of KV7 channels in first trimester placentae.Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (KV7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental tissue. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at ≤ 10 weeks' (early TOP) and >10 weeks' (mid TOP) gestations. KCNQ1-5 expression was unchanged during the first trimester. KCNE5 expression increased in mid TOP vs. early TOP samples (P = 0.022). This novel study reports mRNA and protein expression of KV7 channels in first trimester placentae.
Author	Cartwright, J.E. Tribe, R.M. Broughton Pipkin, F. Mistry, H.D. Whitley, G.S. Kurlak, L.O.
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Cites_doi	10.1161/HYPERTENSIONAHA.111.173740 10.1152/ajpcell.2001.280.2.C359 10.1210/me.2013-1038 10.1152/ajpheart.01033.2001 10.1016/S0302-4598(99)00020-3 10.1111/micc.12069 10.1016/j.placenta.2003.10.009 10.1016/S0026-895X(24)12302-4 10.1016/j.bbrc.2008.02.152 10.1038/35003200 10.1152/ajpregu.00040.2006 10.1016/j.ajog.2004.09.031 10.59566/IJBS.2012.8081 10.1016/j.placenta.2010.02.014 10.1016/j.mvr.2012.12.004 10.1007/s00424-008-0557-7 10.1152/ajprenal.00646.2011
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Keywords	KCNQ Early pregnancy Placenta KCNE Potassium channel Pregnancy Human Vertebrata Mammalia First trimester Ionic channel Inorganic element Potassium
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Snippet	Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (KV7), modulated by KCNE1-5 encoded accessory proteins. The aim was to... Abstract Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (KV 7), modulated by KCNE1-5 encoded accessory proteins. The aim...
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SubjectTerms	Adult Biological and medical sciences Early pregnancy Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Humans Internal Medicine KCNE KCNQ Obstetrics and Gynecology Placenta Placenta - metabolism Potassium channel Potassium Channels, Voltage-Gated - genetics Potassium Channels, Voltage-Gated - metabolism Pregnancy Pregnancy Trimester, First - genetics Pregnancy Trimester, First - metabolism
Title	Expression of voltage-dependent potassium channels in first trimester human placentae
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