Antibiotic-Induced Alterations of the Gut Microbiota Alter Secondary Bile Acid Production and Allow for Clostridium difficile Spore Germination and Outgrowth in the Large Intestine

Antibiotics alter the gastrointestinal microbiota, allowing for Clostridium difficile infection, which is a significant public health problem. Changes in the structure of the gut microbiota alter the metabolome, specifically the production of secondary bile acids. Specific bile acids are able to ini...

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Bibliographic Details

Published in:	mSphere Vol. 1; no. 1
Main Authors:	Theriot, Casey M., Bowman, Alison A., Young, Vincent B.
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 01.01.2016
Subjects:	Antibiotics bile acids Clostridium difficile colonization resistance Gastrointestinal tract Microbiota microbiota colonization resistance bile acids antibiotics Clostridium difficile
ISSN:	2379-5042, 2379-5042
Online Access:	Get full text
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