The association of AGTR2 polymorphisms with preeclampsia and uterine artery bilateral notching is modulated by maternal BMI

This study aimed to determine the association of AGTR1 and AGTR2 polymorphisms with preeclampsia and whether these are affected by environmental factors and fetal sex. Overall 3234 healthy nulliparous women, their partners and babies were recruited prospectively to the SCOPE study in Adelaide and Au...

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Published in:Placenta (Eastbourne) Vol. 34; no. 1; pp. 75 - 81
Main Authors: Zhou, A., Dekker, G.A., Lumbers, E.R., Lee, S.Y., Thompson, S.D., McCowan, L.M.E., Roberts, C.T.
Format: Journal Article
Language:English
Published: Kidlington Elsevier Ltd 01.01.2013
Elsevier
Subjects:
Adult
AGTR2 A1675G
AGTR2 C4599A
Biological and medical sciences
BMI
Body Mass Index
Case-Control Studies
Embryology: invertebrates and vertebrates. Teratology
Female
Fundamental and applied biological sciences. Psychology
Gene-Environment Interaction
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Infant, Newborn
Internal Medicine
Male
Mothers - statistics & numerical data
Obstetrics and Gynecology
Polymorphism
Polymorphism, Single Nucleotide
Pre-Eclampsia - epidemiology
Pre-Eclampsia - genetics
Preeclampsia
Pregnancy
Pregnancy Complications, Cardiovascular - epidemiology
Pregnancy Complications, Cardiovascular - genetics
Receptor, Angiotensin, Type 2 - genetics
Receptor, Angiotensin, Type 2 - metabolism
Uterine Artery - pathology
Uterine artery bilateral notching
Uterine Diseases - epidemiology
Uterine Diseases - genetics
Young Adult
sBP
AGTR2 A1675G
dBP
RAS
SCOPE
AGTR2 C4599A
Preeclampsia
Uterine artery bilateral notching
AGTR2
Polymorphism
BMI
SCreening f Or Pregnancy Endpoints
body mass index
renin angiotensin system
systolic blood pressure
angiotensin II type II receptor
diastolic blood pressure
Body mass index
Vertebrata
Mammalia
Pregnancy disorders
Mother
Blood vessel
Bilateral
Circulatory system
Uterine artery
Pregnancy toxemia
ISSN:0143-4004, 1532-3102, 1532-3102
Online Access:Get full text
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Summary:This study aimed to determine the association of AGTR1 and AGTR2 polymorphisms with preeclampsia and whether these are affected by environmental factors and fetal sex. Overall 3234 healthy nulliparous women, their partners and babies were recruited prospectively to the SCOPE study in Adelaide and Auckland. Data analyses were confined to 2121 Caucasian parent-infant trios, among whom 123 had preeclamptic pregnancies. 1185 uncomplicated pregnancies served as controls. DNA was extracted from buffy coats and genotyped by utilizing the Sequenom MassARRAY system. Doppler sonography on the uterine arteries was performed at 20 weeks' gestation. Four polymorphisms in AGTR1 and AGTR2 genes, including AGTR1 A1166C, AGTR2 C4599A, AGTR2 A1675G and AGTR2 T1134C, were selected and significant associations were predominately observed for AGTR2 C4599A. When the cohort was stratified by maternal BMI, in women with BMI ≥ 25 kg/m2, the AGTR2 C4599A AA genotype in mothers and neonates was associated with an increased risk for preeclampsia compared with the CC genotype [adjusted OR 2.1 (95% CI 1.0–4.2) and adjusted OR 3.0 (95% CI 1.4–6.4), respectively]. In the same subset of women, paternal AGTR2 C4599A A allele was associated with an increased risk for preeclampsia and uterine artery bilateral notching at 20 weeks' gestation compared with the C allele [adjusted OR 1.9 (95% CI 1.1–3.3) and adjusted OR 2.1 (95% CI 1.3–3.4), respectively]. AGTR2 C4599A in mothers, fathers and babies was associated with preeclampsia and this association was only apparent in pregnancies in which the women had a BMI ≥ 25 kg/m2, suggesting a gene–environment interaction.
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ISSN:0143-4004
1532-3102
1532-3102
DOI:10.1016/j.placenta.2012.10.007