Long non-coding RNA-polycomb intimate rendezvous
The interaction between polycomb-repressive complexes 1/2 (PRC1/2) and long non-coding RNA (lncRNA), such as the X inactive specific transcript Xist and the HOX transcript antisense RNA (HOTAIR), has been the subject of intense debate. While cross-linking, immuno-precipitation and super-resolution m...
Uložené v:
| Vydané v: | Open biology Ročník 10; číslo 9; s. 200126 |
|---|---|
| Hlavní autori: | , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
The Royal Society
01.09.2020
|
| Predmet: | |
| ISSN: | 2046-2441, 2046-2441 |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | The interaction between polycomb-repressive complexes 1/2 (PRC1/2) and long non-coding RNA (lncRNA), such as the X inactive specific transcript
Xist
and the HOX transcript antisense RNA (HOTAIR), has been the subject of intense debate. While cross-linking, immuno-precipitation and super-resolution microscopy argue against direct interaction of Polycomb with some lncRNAs, there is increasing evidence supporting the ability of both PRC1 and PRC2 to functionally associate with RNA. Recent data indicate that these interactions are in most cases spurious, but nonetheless crucial for a number of cellular activities. In this review, we suggest that while PRC1/2 recruitment by
HOTAIR
might be direct, in the case of
Xist
, it might occur indirectly and, at least in part, through the process of liquid–liquid phase separation. We present recent models of lncRNA-mediated PRC1/2 recruitment to their targets and describe potential RNA-mediated roles in the three-dimensional organization of the nucleus. |
|---|---|
| AbstractList | The interaction between polycomb-repressive complexes 1/2 (PRC1/2) and long non-coding RNA (lncRNA), such as the X inactive specific transcript Xist and the HOX transcript antisense RNA (HOTAIR), has been the subject of intense debate. While cross-linking, immuno-precipitation and super-resolution microscopy argue against direct interaction of Polycomb with some lncRNAs, there is increasing evidence supporting the ability of both PRC1 and PRC2 to functionally associate with RNA. Recent data indicate that these interactions are in most cases spurious, but nonetheless crucial for a number of cellular activities. In this review, we suggest that while PRC1/2 recruitment by HOTAIR might be direct, in the case of Xist, it might occur indirectly and, at least in part, through the process of liquid-liquid phase separation. We present recent models of lncRNA-mediated PRC1/2 recruitment to their targets and describe potential RNA-mediated roles in the three-dimensional organization of the nucleus.The interaction between polycomb-repressive complexes 1/2 (PRC1/2) and long non-coding RNA (lncRNA), such as the X inactive specific transcript Xist and the HOX transcript antisense RNA (HOTAIR), has been the subject of intense debate. While cross-linking, immuno-precipitation and super-resolution microscopy argue against direct interaction of Polycomb with some lncRNAs, there is increasing evidence supporting the ability of both PRC1 and PRC2 to functionally associate with RNA. Recent data indicate that these interactions are in most cases spurious, but nonetheless crucial for a number of cellular activities. In this review, we suggest that while PRC1/2 recruitment by HOTAIR might be direct, in the case of Xist, it might occur indirectly and, at least in part, through the process of liquid-liquid phase separation. We present recent models of lncRNA-mediated PRC1/2 recruitment to their targets and describe potential RNA-mediated roles in the three-dimensional organization of the nucleus. The interaction between polycomb-repressive complexes 1/2 (PRC1/2) and long non-coding RNA (lncRNA), such as the X inactive specific transcript Xist and the HOX transcript antisense RNA (HOTAIR), has been the subject of intense debate. While cross-linking, immuno-precipitation and super-resolution microscopy argue against direct interaction of Polycomb with some lncRNAs, there is increasing evidence supporting the ability of both PRC1 and PRC2 to functionally associate with RNA. Recent data indicate that these interactions are in most cases spurious, but nonetheless crucial for a number of cellular activities. In this review, we suggest that while PRC1/2 recruitment by HOTAIR might be direct, in the case of Xist, it might occur indirectly and, at least in part, through the process of liquid–liquid phase separation. We present recent models of lncRNA-mediated PRC1/2 recruitment to their targets and describe potential RNA-mediated roles in the three-dimensional organization of the nucleus. The interaction between polycomb-repressive complexes 1/2 (PRC1/2) and long non-coding RNA (lncRNA), such as the X inactive specific transcript Xist and the HOX transcript antisense RNA (HOTAIR), has been the subject of intense debate. While cross-linking, immuno-precipitation and super-resolution microscopy argue against direct interaction of Polycomb with some lncRNAs, there is increasing evidence supporting the ability of both PRC1 and PRC2 to functionally associate with RNA. Recent data indicate that these interactions are in most cases spurious, but nonetheless crucial for a number of cellular activities. In this review, we suggest that while PRC1/2 recruitment by HOTAIR might be direct, in the case of Xist , it might occur indirectly and, at least in part, through the process of liquid–liquid phase separation. We present recent models of lncRNA-mediated PRC1/2 recruitment to their targets and describe potential RNA-mediated roles in the three-dimensional organization of the nucleus. |
| Author | Tartaglia, Gian Gaetano Cerase, Andrea |
| AuthorAffiliation | 1 Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London , London E1 2AT , UK 6 Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia (IIT) , Via Morego 30, 16163, Genoa , Italy 5 Department of Biology ‘Charles Darwin’, Sapienza University of Rome , P.le A. Moro 5, Rome 00185 , Italy 3 Universitat Pompeu Fabra (UPF) , 08003 Barcelona , Spain 2 Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology , Dr. Aiguader 88, 08003 Barcelona , Spain 4 Institucio Catalana de Recerca i Estudis Avançats (ICREA), 23 Passeig Lluis Companys , 08010 Barcelona , Spain |
| AuthorAffiliation_xml | – name: 6 Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia (IIT) , Via Morego 30, 16163, Genoa , Italy – name: 1 Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London , London E1 2AT , UK – name: 5 Department of Biology ‘Charles Darwin’, Sapienza University of Rome , P.le A. Moro 5, Rome 00185 , Italy – name: 2 Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology , Dr. Aiguader 88, 08003 Barcelona , Spain – name: 3 Universitat Pompeu Fabra (UPF) , 08003 Barcelona , Spain – name: 4 Institucio Catalana de Recerca i Estudis Avançats (ICREA), 23 Passeig Lluis Companys , 08010 Barcelona , Spain |
| Author_xml | – sequence: 1 givenname: Andrea orcidid: 0000-0002-1985-2049 surname: Cerase fullname: Cerase, Andrea organization: Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK – sequence: 2 givenname: Gian Gaetano orcidid: 0000-0001-7524-6310 surname: Tartaglia fullname: Tartaglia, Gian Gaetano organization: Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain, Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain, Institucio Catalana de Recerca i Estudis Avançats (ICREA), 23 Passeig Lluis Companys, 08010 Barcelona, Spain, Department of Biology ‘Charles Darwin’, Sapienza University of Rome, P.le A. Moro 5, Rome 00185, Italy, Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia (IIT), Via Morego 30, 16163, Genoa, Italy |
| BookMark | eNptkdtKAzEQhoNUPFSvfIFeCrKaZHPaG6GIJygKotchyc7WyHZTk62gT2_WKlhxbmaY-edjmH8fjbrQAUJHBJ8SXKmzmII9pRgTKrbQHsVMFJQxMvpV76LDlF5wDi5IxcgO2i2pqhSTdA_hWejmkwwtXKh9Lh_upsUytO8uLOzEd71fmB4mEboaPt7CKh2g7ca0CQ6_8xg9XV0-XtwUs_vr24vprHCci76Qjjem4gpKZhvSCOMwA1JayazABCsJTmKqTOM45UxiJyqoFZecDEoqyzG6XXPrYF70MuY74rsOxuuvRohzbWLvXQta1Za6SiglcMkqC5UUqiRgayKNcNZk1vmatVzZBdQOuj6adgO6Oen8s56HNy15KbDgGXD8DYjhdQWp1wufHLSt6SD_RA9vpooJQrKUrKUuhpQiNNr53vQ-DGTfaoL1YJwejNNr4_LOyZ-dn9P-U38CpM6Z0w |
| CitedBy_id | crossref_primary_10_1002_iub_2673 crossref_primary_10_1007_s40618_021_01559_8 crossref_primary_10_3389_fmolb_2022_893067 crossref_primary_10_1080_07391102_2022_2116110 crossref_primary_10_1038_s42003_021_01945_1 crossref_primary_10_3390_ncrna11020020 crossref_primary_10_1002_wrna_1657 crossref_primary_10_1016_j_gde_2024_102304 crossref_primary_10_3389_fcell_2021_735527 crossref_primary_10_1016_j_neuint_2021_105184 crossref_primary_10_1016_j_cca_2025_120427 crossref_primary_10_1016_j_jmb_2021_167159 crossref_primary_10_3390_ncrna7020036 crossref_primary_10_1186_s43556_025_00254_x crossref_primary_10_1002_bies_202000118 crossref_primary_10_1002_wrna_1870 crossref_primary_10_1002_alz_14498 crossref_primary_10_1007_s12013_024_01287_9 crossref_primary_10_1016_j_pneurobio_2022_102353 crossref_primary_10_1186_s13059_025_03666_8 crossref_primary_10_3390_cancers13133115 crossref_primary_10_3390_biology12030374 |
| Cites_doi | 10.1101/gr.197632.115 10.1016/j.molcel.2010.03.019 10.1016/j.tcb.2019.05.004 10.7554/eLife.31558 10.1083/jcb.201601071 10.1126/science.aai8236 10.1371/journal.pbio.1000276 10.1038/nrm.2016.126 10.1091/mbc.e13-09-0558 10.1126/sciadv.1700944 10.1016/j.semcdb.2016.03.023 10.1021/bi401085h 10.1038/s41467-018-05728-x 10.1016/j.gde.2020.02.023 10.1126/science.1192002 10.1093/bioinformatics/btt495 10.1016/j.ceb.2017.01.007 10.1016/j.celrep.2015.06.053 10.1126/science.1092674 10.1016/j.molcel.2013.02.013 10.1016/j.celrep.2014.04.012 10.1016/j.molcel.2017.02.003 10.1126/science.aae0047 10.1093/nar/gks968 10.1038/s41467-019-10923-5 10.1126/sciadv.aao2110 10.15252/embr.201744147 10.1038/nsmb.2679 10.1038/ng.3192 10.1126/science.aal2512 10.1016/j.cell.2014.05.004 10.1093/nar/gkx1048 10.1038/nsmb.3487 10.1002/bies.201800222 10.1016/j.molcel.2019.12.001 10.1007/s12015-015-9597-5 10.1007/s00412-015-0539-4 10.1016/j.tig.2019.11.004 10.1038/ncomms3939 10.1016/j.celrep.2019.10.011 10.1016/j.molcel.2017.11.013 10.1016/j.cub.2016.03.022 10.3389/fmolb.2018.00111 10.1038/nsmb.2848 10.7554/eLife.14926 10.1126/sciadv.1500737 10.1038/s41594-019-0223-0 10.1074/mcp.M114.043984 10.1016/j.cell.2017.09.043 10.1146/annurev-cellbio-100913-013325 10.1038/nature14443 10.1126/sciadv.aax4001 10.1016/j.cell.2007.05.022 10.1016/j.stem.2010.08.004 10.1016/j.celrep.2016.05.076 10.1016/j.molcel.2015.03.006 10.1038/nature08975 10.1080/19491034.2017.1363136 10.1126/science.aab2276 10.1016/j.celrep.2018.03.002 10.1038/nmeth.4100 10.1073/pnas.1312951111 10.1016/j.cell.2015.03.025 10.1016/j.celrep.2015.06.067 10.1080/10409238.2019.1679082 10.1038/s41594-019-0197-y 10.1242/dev.120030 10.1016/j.cell.2016.05.004 10.1101/2019.12.23.887547 10.1038/ncb1663 10.1016/j.molcel.2018.12.016 10.1016/j.celrep.2018.11.076 10.1016/j.molcel.2014.05.009 10.1242/dev.091553 10.1093/bioinformatics/btz666 10.26226/morressier.5ebd45acffea6f735881b19a 10.1016/j.molcel.2019.11.021 10.1101/gad.337196.120 10.1016/j.molcel.2019.05.028 10.1038/nmeth.1611 10.1016/j.molcel.2016.06.003 10.1016/j.exphem.2016.12.006 10.1242/dev.128.6.993 10.1016/j.molcel.2014.01.002 10.1038/nature08398 10.1371/journal.pgen.1005668 10.7554/eLife.02637 10.1038/s41588-020-0662-x 10.1126/science.1163045 10.1016/j.devcel.2013.08.016 10.1093/nar/gky967 10.1038/nsmb.2764 10.1186/s13059-015-0733-y 10.3389/fmolb.2017.00090 10.1007/s00412-015-0525-x 10.1016/j.cell.2016.05.026 10.1038/s41594-019-0293-z 10.1016/j.molcel.2010.03.021 10.1016/j.devcel.2004.10.005 10.1016/j.gde.2019.06.006 10.1101/cshperspect.a026575 10.1038/leu.2016.2 10.1016/j.cell.2011.09.028 10.1126/science.1092727 10.1126/science.1084274 10.1101/gad.470008 |
| ContentType | Journal Article |
| Copyright | 2020 The Authors. 2020 |
| Copyright_xml | – notice: 2020 The Authors. 2020 |
| DBID | AAYXX CITATION 7X8 5PM DOA |
| DOI | 10.1098/rsob.200126 |
| DatabaseName | CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic CrossRef |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| DocumentTitleAlternate | LncRNA and Polycomb |
| EISSN | 2046-2441 |
| ExternalDocumentID | oai_doaj_org_article_8db2c968860349be976831ebd17a6cba PMC7536065 10_1098_rsob_200126 |
| GrantInformation_xml | – fundername: ; – fundername: ; grantid: Intramural funding – fundername: ; grantid: ASTRA 855923 – fundername: ; grantid: BFU2017-86970-P – fundername: ; grantid: Small grant |
| GroupedDBID | 53G 5VS 88I AAFWJ AAYXX ABUWG ACQIA ADBBV ADRAZ AENEX AFFHD AFKRA AFPKN ALAEF ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BTFSW CCPQU CITATION DIK DWQXO EBS EJD FRP GNUQQ GROUPED_DOAJ GX1 H13 HCIFZ HYE ICLEN KQ8 M2P M48 M7P M~E OK1 OP1 PGMZT PHGZM PHGZT PIMPY PQGLB RPM 7X8 5PM |
| ID | FETCH-LOGICAL-c556t-7c5fa958e34bf1f6ac04e13b74b601087ec7028afc525470c69ed85751ac04273 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 24 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000571577500002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2046-2441 |
| IngestDate | Fri Oct 03 12:49:04 EDT 2025 Tue Sep 30 16:57:43 EDT 2025 Fri Jul 11 12:44:52 EDT 2025 Tue Nov 18 22:14:41 EST 2025 Sat Nov 29 06:31:33 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 9 |
| Language | English |
| License | Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c556t-7c5fa958e34bf1f6ac04e13b74b601087ec7028afc525470c69ed85751ac04273 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Electronic supplementary material is available online at https://doi.org/10.6084/m9.figshare.c.5112415. |
| ORCID | 0000-0002-1985-2049 0000-0001-7524-6310 |
| OpenAccessLink | https://doaj.org/article/8db2c968860349be976831ebd17a6cba |
| PMID | 32898472 |
| PQID | 2441284611 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_8db2c968860349be976831ebd17a6cba pubmedcentral_primary_oai_pubmedcentral_nih_gov_7536065 proquest_miscellaneous_2441284611 crossref_citationtrail_10_1098_rsob_200126 crossref_primary_10_1098_rsob_200126 |
| PublicationCentury | 2000 |
| PublicationDate | 2020-09-01 |
| PublicationDateYYYYMMDD | 2020-09-01 |
| PublicationDate_xml | – month: 09 year: 2020 text: 2020-09-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationTitle | Open biology |
| PublicationYear | 2020 |
| Publisher | The Royal Society |
| Publisher_xml | – name: The Royal Society |
| References | e_1_3_4_3_2 e_1_3_4_110_2 e_1_3_4_61_2 e_1_3_4_84_2 e_1_3_4_7_2 e_1_3_4_80_2 e_1_3_4_23_2 e_1_3_4_69_2 e_1_3_4_42_2 e_1_3_4_27_2 e_1_3_4_65_2 e_1_3_4_46_2 e_1_3_4_88_2 Bhan A (e_1_3_4_77_2) 2015; 1856 e_1_3_4_102_2 e_1_3_4_72_2 e_1_3_4_95_2 e_1_3_4_106_2 e_1_3_4_30_2 e_1_3_4_91_2 e_1_3_4_11_2 e_1_3_4_34_2 e_1_3_4_57_2 e_1_3_4_53_2 e_1_3_4_15_2 e_1_3_4_38_2 e_1_3_4_76_2 e_1_3_4_19_2 e_1_3_4_2_2 e_1_3_4_62_2 e_1_3_4_85_2 e_1_3_4_6_2 e_1_3_4_81_2 e_1_3_4_20_2 e_1_3_4_43_2 e_1_3_4_24_2 e_1_3_4_47_2 e_1_3_4_66_2 e_1_3_4_89_2 e_1_3_4_101_2 e_1_3_4_73_2 e_1_3_4_96_2 e_1_3_4_105_2 e_1_3_4_50_2 e_1_3_4_92_2 e_1_3_4_109_2 e_1_3_4_12_2 e_1_3_4_58_2 e_1_3_4_54_2 e_1_3_4_31_2 e_1_3_4_16_2 e_1_3_4_35_2 e_1_3_4_39_2 e_1_3_4_82_2 e_1_3_4_9_2 e_1_3_4_63_2 e_1_3_4_40_2 e_1_3_4_5_2 e_1_3_4_44_2 e_1_3_4_21_2 e_1_3_4_48_2 e_1_3_4_86_2 e_1_3_4_25_2 e_1_3_4_67_2 e_1_3_4_29_2 Ransohoff JD (e_1_3_4_28_2) 2018; 19 e_1_3_4_100_2 e_1_3_4_93_2 Pachano T (e_1_3_4_99_2) 2019; 18 e_1_3_4_104_2 e_1_3_4_51_2 e_1_3_4_108_2 e_1_3_4_70_2 e_1_3_4_55_2 e_1_3_4_32_2 e_1_3_4_59_2 e_1_3_4_97_2 e_1_3_4_13_2 e_1_3_4_36_2 e_1_3_4_78_2 e_1_3_4_17_2 e_1_3_4_111_2 e_1_3_4_60_2 e_1_3_4_83_2 e_1_3_4_8_2 e_1_3_4_41_2 Ponti RD (e_1_3_4_74_2) 2020; 36 e_1_3_4_4_2 e_1_3_4_22_2 e_1_3_4_45_2 e_1_3_4_68_2 e_1_3_4_26_2 e_1_3_4_49_2 e_1_3_4_64_2 e_1_3_4_87_2 e_1_3_4_71_2 e_1_3_4_94_2 e_1_3_4_103_2 e_1_3_4_52_2 e_1_3_4_90_2 e_1_3_4_107_2 e_1_3_4_79_2 e_1_3_4_33_2 e_1_3_4_10_2 e_1_3_4_75_2 e_1_3_4_98_2 e_1_3_4_37_2 e_1_3_4_14_2 e_1_3_4_56_2 e_1_3_4_18_2 |
| References_xml | – ident: e_1_3_4_109_2 doi: 10.1101/gr.197632.115 – ident: e_1_3_4_95_2 doi: 10.1016/j.molcel.2010.03.019 – ident: e_1_3_4_10_2 doi: 10.1016/j.tcb.2019.05.004 – ident: e_1_3_4_66_2 doi: 10.7554/eLife.31558 – ident: e_1_3_4_108_2 doi: 10.1083/jcb.201601071 – volume: 19 start-page: 143 year: 2018 ident: e_1_3_4_28_2 article-title: The functions and unique features of long intergenic non-coding RNA. Nature reviews publication-title: Mol. Cell Biol. – ident: e_1_3_4_111_2 doi: 10.1126/science.aai8236 – ident: e_1_3_4_83_2 doi: 10.1371/journal.pbio.1000276 – ident: e_1_3_4_29_2 doi: 10.1038/nrm.2016.126 – ident: e_1_3_4_43_2 doi: 10.1091/mbc.e13-09-0558 – ident: e_1_3_4_90_2 doi: 10.1126/sciadv.1700944 – ident: e_1_3_4_41_2 doi: 10.1016/j.semcdb.2016.03.023 – ident: e_1_3_4_65_2 doi: 10.1021/bi401085h – ident: e_1_3_4_8_2 doi: 10.1038/s41467-018-05728-x – ident: e_1_3_4_51_2 doi: 10.1016/j.gde.2020.02.023 – ident: e_1_3_4_64_2 doi: 10.1126/science.1192002 – ident: e_1_3_4_69_2 doi: 10.1093/bioinformatics/btt495 – ident: e_1_3_4_48_2 doi: 10.1016/j.ceb.2017.01.007 – ident: e_1_3_4_34_2 doi: 10.1016/j.celrep.2015.06.053 – ident: e_1_3_4_56_2 doi: 10.1126/science.1092674 – ident: e_1_3_4_22_2 doi: 10.1016/j.molcel.2013.02.013 – ident: e_1_3_4_17_2 doi: 10.1016/j.celrep.2014.04.012 – volume: 18 start-page: 358 year: 2019 ident: e_1_3_4_99_2 article-title: Polycomb proteins as organizers of 3D genome architecture in embryonic stem cells publication-title: Brief Funct. Genomics – ident: e_1_3_4_19_2 doi: 10.1016/j.molcel.2017.02.003 – ident: e_1_3_4_39_2 doi: 10.1126/science.aae0047 – ident: e_1_3_4_71_2 doi: 10.1093/nar/gks968 – ident: e_1_3_4_73_2 doi: 10.1038/s41467-019-10923-5 – ident: e_1_3_4_33_2 doi: 10.1126/sciadv.aao2110 – ident: e_1_3_4_44_2 doi: 10.15252/embr.201744147 – ident: e_1_3_4_106_2 doi: 10.1038/nsmb.2679 – ident: e_1_3_4_30_2 doi: 10.1038/ng.3192 – ident: e_1_3_4_59_2 doi: 10.1126/science.aal2512 – ident: e_1_3_4_60_2 doi: 10.1016/j.cell.2014.05.004 – ident: e_1_3_4_81_2 doi: 10.1093/nar/gkx1048 – ident: e_1_3_4_105_2 doi: 10.1038/nsmb.3487 – ident: e_1_3_4_26_2 doi: 10.1002/bies.201800222 – ident: e_1_3_4_23_2 doi: 10.1016/j.molcel.2019.12.001 – ident: e_1_3_4_32_2 doi: 10.1007/s12015-015-9597-5 – ident: e_1_3_4_5_2 doi: 10.1007/s00412-015-0539-4 – ident: e_1_3_4_27_2 doi: 10.1016/j.tig.2019.11.004 – ident: e_1_3_4_85_2 doi: 10.1038/ncomms3939 – ident: e_1_3_4_94_2 doi: 10.1016/j.celrep.2019.10.011 – ident: e_1_3_4_55_2 doi: 10.1016/j.molcel.2017.11.013 – ident: e_1_3_4_47_2 doi: 10.1016/j.cub.2016.03.022 – ident: e_1_3_4_75_2 doi: 10.3389/fmolb.2018.00111 – ident: e_1_3_4_61_2 doi: 10.1038/nsmb.2848 – ident: e_1_3_4_7_2 doi: 10.7554/eLife.14926 – ident: e_1_3_4_11_2 doi: 10.1126/sciadv.1500737 – ident: e_1_3_4_68_2 doi: 10.1038/s41594-019-0223-0 – ident: e_1_3_4_84_2 doi: 10.1074/mcp.M114.043984 – ident: e_1_3_4_100_2 doi: 10.1016/j.cell.2017.09.043 – ident: e_1_3_4_78_2 doi: 10.1146/annurev-cellbio-100913-013325 – ident: e_1_3_4_38_2 doi: 10.1038/nature14443 – ident: e_1_3_4_89_2 doi: 10.1126/sciadv.aax4001 – ident: e_1_3_4_62_2 doi: 10.1016/j.cell.2007.05.022 – ident: e_1_3_4_103_2 doi: 10.1016/j.stem.2010.08.004 – ident: e_1_3_4_46_2 doi: 10.1016/j.celrep.2016.05.076 – ident: e_1_3_4_54_2 doi: 10.1016/j.molcel.2015.03.006 – ident: e_1_3_4_63_2 doi: 10.1038/nature08975 – ident: e_1_3_4_4_2 doi: 10.1080/19491034.2017.1363136 – ident: e_1_3_4_37_2 doi: 10.1126/science.aab2276 – ident: e_1_3_4_9_2 doi: 10.1016/j.celrep.2018.03.002 – ident: e_1_3_4_36_2 doi: 10.1038/nmeth.4100 – ident: e_1_3_4_58_2 doi: 10.1073/pnas.1312951111 – ident: e_1_3_4_40_2 doi: 10.1016/j.cell.2015.03.025 – ident: e_1_3_4_35_2 doi: 10.1016/j.celrep.2015.06.067 – ident: e_1_3_4_88_2 doi: 10.1080/10409238.2019.1679082 – ident: e_1_3_4_21_2 doi: 10.1038/s41594-019-0197-y – ident: e_1_3_4_3_2 doi: 10.1242/dev.120030 – ident: e_1_3_4_79_2 doi: 10.1016/j.cell.2016.05.004 – ident: e_1_3_4_93_2 doi: 10.1101/2019.12.23.887547 – ident: e_1_3_4_91_2 doi: 10.1038/ncb1663 – ident: e_1_3_4_98_2 doi: 10.1016/j.molcel.2018.12.016 – ident: e_1_3_4_72_2 doi: 10.1016/j.celrep.2018.11.076 – ident: e_1_3_4_107_2 doi: 10.1016/j.molcel.2014.05.009 – ident: e_1_3_4_6_2 doi: 10.1242/dev.091553 – volume: 36 start-page: 940 year: 2020 ident: e_1_3_4_74_2 article-title: CROSSalive: a web server for predicting the in vivo structure of RNA molecules publication-title: Bioinformatics doi: 10.1093/bioinformatics/btz666 – ident: e_1_3_4_82_2 doi: 10.26226/morressier.5ebd45acffea6f735881b19a – ident: e_1_3_4_24_2 doi: 10.1016/j.molcel.2019.11.021 – ident: e_1_3_4_50_2 doi: 10.1101/gad.337196.120 – ident: e_1_3_4_104_2 doi: 10.1016/j.molcel.2019.05.028 – ident: e_1_3_4_67_2 doi: 10.1038/nmeth.1611 – ident: e_1_3_4_97_2 doi: 10.1016/j.molcel.2016.06.003 – ident: e_1_3_4_12_2 doi: 10.1016/j.exphem.2016.12.006 – volume: 1856 start-page: 151 year: 2015 ident: e_1_3_4_77_2 article-title: LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer publication-title: Biochim. Biophys. Acta – ident: e_1_3_4_2_2 doi: 10.1242/dev.128.6.993 – ident: e_1_3_4_53_2 doi: 10.1016/j.molcel.2014.01.002 – ident: e_1_3_4_16_2 doi: 10.1038/nature08398 – ident: e_1_3_4_76_2 doi: 10.1371/journal.pgen.1005668 – ident: e_1_3_4_20_2 doi: 10.7554/eLife.02637 – ident: e_1_3_4_96_2 doi: 10.1038/s41588-020-0662-x – ident: e_1_3_4_52_2 doi: 10.1126/science.1163045 – ident: e_1_3_4_87_2 doi: 10.1016/j.devcel.2013.08.016 – ident: e_1_3_4_70_2 doi: 10.1093/nar/gky967 – ident: e_1_3_4_101_2 doi: 10.1038/nsmb.2764 – ident: e_1_3_4_31_2 doi: 10.1186/s13059-015-0733-y – ident: e_1_3_4_45_2 doi: 10.3389/fmolb.2017.00090 – ident: e_1_3_4_49_2 doi: 10.1007/s00412-015-0525-x – ident: e_1_3_4_80_2 doi: 10.1016/j.cell.2016.05.026 – ident: e_1_3_4_102_2 doi: 10.1038/s41594-019-0293-z – ident: e_1_3_4_92_2 doi: 10.1016/j.molcel.2010.03.021 – ident: e_1_3_4_15_2 doi: 10.1016/j.devcel.2004.10.005 – ident: e_1_3_4_86_2 doi: 10.1016/j.gde.2019.06.006 – ident: e_1_3_4_25_2 doi: 10.1101/cshperspect.a026575 – ident: e_1_3_4_13_2 doi: 10.1038/leu.2016.2 – ident: e_1_3_4_110_2 – ident: e_1_3_4_42_2 doi: 10.1016/j.cell.2011.09.028 – ident: e_1_3_4_57_2 doi: 10.1126/science.1092727 – ident: e_1_3_4_14_2 doi: 10.1126/science.1084274 – ident: e_1_3_4_18_2 doi: 10.1101/gad.470008 |
| SSID | ssj0000561941 |
| Score | 2.333525 |
| SecondaryResourceType | review_article |
| Snippet | The interaction between polycomb-repressive complexes 1/2 (PRC1/2) and long non-coding RNA (lncRNA), such as the X inactive specific transcript
Xist
and the... The interaction between polycomb-repressive complexes 1/2 (PRC1/2) and long non-coding RNA (lncRNA), such as the X inactive specific transcript Xist and the... |
| SourceID | doaj pubmedcentral proquest crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Enrichment Source Index Database |
| StartPage | 200126 |
| SubjectTerms | hotair rna long non-coding rnas (lncrna) phase separation polycomb-repressive complexes 1/2 (prc1/2) Review rna secondary structure rna–protein interaction xist rna |
| Title | Long non-coding RNA-polycomb intimate rendezvous |
| URI | https://www.proquest.com/docview/2441284611 https://pubmed.ncbi.nlm.nih.gov/PMC7536065 https://doaj.org/article/8db2c968860349be976831ebd17a6cba |
| Volume | 10 |
| WOSCitedRecordID | wos000571577500002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2046-2441 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000561941 issn: 2046-2441 databaseCode: DOA dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2046-2441 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000561941 issn: 2046-2441 databaseCode: M~E dateStart: 20110101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVAUN databaseName: Royal Society Open Access customDbUrl: eissn: 2046-2441 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000561941 issn: 2046-2441 databaseCode: OP1 dateStart: 20110901 isFulltext: true titleUrlDefault: http://royalsocietypublishing.org/journals providerName: Royal Society Publications |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LS8NAEB60KHgRnxgfJUJPQmg3j30cqygeai2i0lvIbjZakFS0CvXgb3cmSUsCghcve0iGZJnZZb6Pnf0GoBNaPxEaN5LUSYoEJVSeDDQOYaaUbyLLi9YJjwMxHMrxWI1qrb6oJqyUBy4d15Wp9o3iUnJSUtEW06cMmNUpEwk3uoBGiHpqZKpU9SZ2zqoLeT0luwhfNdFBRjIKtRRUKPU34GWzOLKWba62YLOCiW6_nN42rNh8B9bLxpHzXegNpvmTi8zdM1NKPu7dsO-9Tl_muH60O8lnEwSi1qV6V_v1ieR-Dx6uLu8vrr2q94FnoojPPGGiLFGRtEGoM5bxxPRCywItQk0USgprBEKDJDMRUjzRM1zZlLptMrJETLIPLZyFPQAXOYsoTlQso94imRRZgLsSP6p9nkrlwNnCHbGphMGpP8VLXB5Qy5h8F5e-c6CzNH4t9TB-Nzsnvy5NSMS6eIChjavQxn-F1oHTRVRiXPR0kpHkFn0WIyahvMoZc0A0wtX4Y_NNPnku5LORoCFriw7_Y4pHsOETAS-Kzo6hNXv7sCewZj5nk_e3NqyKsWwXKxPHm-9LHG9H7AeEKOoZ |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Long+non-coding+RNA-polycomb+intimate+rendezvous&rft.jtitle=Open+biology&rft.au=Andrea%C2%A0Cerase&rft.au=Gian+Gaetano%C2%A0Tartaglia&rft.date=2020-09-01&rft.pub=The+Royal+Society&rft.eissn=2046-2441&rft.volume=10&rft.issue=9&rft_id=info:doi/10.1098%2Frsob.200126&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_8db2c968860349be976831ebd17a6cba |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2046-2441&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2046-2441&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2046-2441&client=summon |