VTA GABA Neurons at the Interface of Stress and Reward

The ventral tegmental area (VTA) is best known for its robust dopaminergic projections to forebrain regions and their critical role in regulating reward, motivation, cognition, and aversion. However, the VTA is not only made of dopamine (DA) cells, as approximately 30% of cells in the VTA are GABA n...

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Vydané v:	Frontiers in neural circuits Ročník 13; s. 78
Hlavní autori:	Bouarab, Chloé, Thompson, Brittney, Polter, Abigail M.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Switzerland Frontiers Research Foundation 05.12.2019 Frontiers Media S.A
Predmet:	Addictions Animals Aversion circuits Cognition Dopamine Dopamine receptors Dopaminergic Neurons - physiology Forebrain GABA GABAergic Neurons - physiology Motivation Neural Inhibition - physiology Neural Pathways - physiology Neurons Neuroscience Physiology Reinforcement Reward stress Stress, Psychological - physiopathology ventral tegmental area (VTA) Ventral Tegmental Area - physiology Ventral tegmentum γ-Aminobutyric acid reward GABA stress circuits ventral tegmental area (VTA)
ISSN:	1662-5110, 1662-5110
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Shrnutí:	The ventral tegmental area (VTA) is best known for its robust dopaminergic projections to forebrain regions and their critical role in regulating reward, motivation, cognition, and aversion. However, the VTA is not only made of dopamine (DA) cells, as approximately 30% of cells in the VTA are GABA neurons. These neurons play a dual role, as VTA GABA neurons provide both local inhibition of VTA DA neurons and long-range inhibition of several distal brain regions. VTA GABA neurons have increasingly been recognized as potent mediators of reward and aversion in their own right, as well as potential targets for the treatment of addiction, depression, and other stress-linked disorders. In this review article, we dissect the circuit architecture, physiology, and behavioral roles of VTA GABA neurons and suggest critical gaps to be addressed.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 Edited by: Fu-Ming Zhou, University of Tennessee Health Science Center (UTHSC), United States Reviewed by: Aaron G. Roseberry, Georgia State University, United States; Jeffrey G. Edwards, Brigham Young University, United States
ISSN:	1662-5110 1662-5110
DOI:	10.3389/fncir.2019.00078