VTA GABA Neurons at the Interface of Stress and Reward

The ventral tegmental area (VTA) is best known for its robust dopaminergic projections to forebrain regions and their critical role in regulating reward, motivation, cognition, and aversion. However, the VTA is not only made of dopamine (DA) cells, as approximately 30% of cells in the VTA are GABA n...

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Vydané v:Frontiers in neural circuits Ročník 13; s. 78
Hlavní autori: Bouarab, Chloé, Thompson, Brittney, Polter, Abigail M.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland Frontiers Research Foundation 05.12.2019
Frontiers Media S.A
Predmet:
Addictions
Animals
Aversion
circuits
Cognition
Dopamine
Dopamine receptors
Dopaminergic Neurons - physiology
Forebrain
GABA
GABAergic Neurons - physiology
Motivation
Neural Inhibition - physiology
Neural Pathways - physiology
Neurons
Neuroscience
Physiology
Reinforcement
Reward
stress
Stress, Psychological - physiopathology
ventral tegmental area (VTA)
Ventral Tegmental Area - physiology
Ventral tegmentum
γ-Aminobutyric acid
reward
GABA
stress
circuits
ventral tegmental area (VTA)
ISSN:1662-5110, 1662-5110
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Abstract The ventral tegmental area (VTA) is best known for its robust dopaminergic projections to forebrain regions and their critical role in regulating reward, motivation, cognition, and aversion. However, the VTA is not only made of dopamine (DA) cells, as approximately 30% of cells in the VTA are GABA neurons. These neurons play a dual role, as VTA GABA neurons provide both local inhibition of VTA DA neurons and long-range inhibition of several distal brain regions. VTA GABA neurons have increasingly been recognized as potent mediators of reward and aversion in their own right, as well as potential targets for the treatment of addiction, depression, and other stress-linked disorders. In this review article, we dissect the circuit architecture, physiology, and behavioral roles of VTA GABA neurons and suggest critical gaps to be addressed.
AbstractList The ventral tegmental area (VTA) is best known for its robust dopaminergic projections to forebrain regions and their critical role in regulating reward, motivation, cognition, and aversion. However, the VTA is not only made of dopamine (DA) cells, as approximately 30% of cells in the VTA are GABA neurons. These neurons play a dual role, as VTA GABA neurons provide both local inhibition of VTA DA neurons and long-range inhibition of several distal brain regions. VTA GABA neurons have increasingly been recognized as potent mediators of reward and aversion in their own right, as well as potential targets for the treatment of addiction, depression, and other stress-linked disorders. In this review article, we dissect the circuit architecture, physiology, and behavioral roles of VTA GABA neurons and suggest critical gaps to be addressed.
The ventral tegmental area (VTA) is best known for its robust dopaminergic projections to forebrain regions and their critical role in regulating reward, motivation, cognition, and aversion. However, the VTA is not only made of dopamine (DA) cells, as approximately 30% of cells in the VTA are GABA neurons. These neurons play a dual role, as VTA GABA neurons provide both local inhibition of VTA DA neurons and long-range inhibition of several distal brain regions. VTA GABA neurons have increasingly been recognized as potent mediators of reward and aversion in their own right, as well as potential targets for the treatment of addiction, depression, and other stress-linked disorders. In this review article, we dissect the circuit architecture, physiology, and behavioral roles of VTA GABA neurons and suggest critical gaps to be addressed.The ventral tegmental area (VTA) is best known for its robust dopaminergic projections to forebrain regions and their critical role in regulating reward, motivation, cognition, and aversion. However, the VTA is not only made of dopamine (DA) cells, as approximately 30% of cells in the VTA are GABA neurons. These neurons play a dual role, as VTA GABA neurons provide both local inhibition of VTA DA neurons and long-range inhibition of several distal brain regions. VTA GABA neurons have increasingly been recognized as potent mediators of reward and aversion in their own right, as well as potential targets for the treatment of addiction, depression, and other stress-linked disorders. In this review article, we dissect the circuit architecture, physiology, and behavioral roles of VTA GABA neurons and suggest critical gaps to be addressed.
The ventral tegmental area (VTA) is best known for its robust dopaminergic projections to forebrain regions and their critical role in regulating reward, motivation, cognition, and aversion. However, the VTA is not only made of dopamine (DA) cells, as approximately 35% of cells in the VTA are GABA neurons. These neurons play a dual role, as VTA GABA neurons provide both local inhibition of VTA DA neurons and long-range inhibition of several distal brain regions. VTA GABA neurons have increasingly been recognized as potent mediators of reward and aversion in their own right, as well as potential targets for the treatment of addiction, depression, and other stress-linked disorders. In this review, we dissect the circuit architecture, physiology, and behavioral roles of VTA GABA neurons and suggest critical gaps to be addressed.
Author Polter, Abigail M.
Bouarab, Chloé
Thompson, Brittney
AuthorAffiliation Department of Pharmacology and Physiology, Institute for Neuroscience, George Washington University School of Medicine and Health Sciences , Washington, DC , United States
AuthorAffiliation_xml – name: Department of Pharmacology and Physiology, Institute for Neuroscience, George Washington University School of Medicine and Health Sciences , Washington, DC , United States
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  givenname: Abigail M.
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/31866835$$D View this record in MEDLINE/PubMed
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Copyright © 2019 Bouarab, Thompson and Polter. 2019 Bouarab, Thompson and Polter
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Keywords reward
GABA
stress
circuits
ventral tegmental area (VTA)
Language English
License Copyright © 2019 Bouarab, Thompson and Polter.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Edited by: Fu-Ming Zhou, University of Tennessee Health Science Center (UTHSC), United States
Reviewed by: Aaron G. Roseberry, Georgia State University, United States; Jeffrey G. Edwards, Brigham Young University, United States
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PublicationTitle Frontiers in neural circuits
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Snippet The ventral tegmental area (VTA) is best known for its robust dopaminergic projections to forebrain regions and their critical role in regulating reward,...
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StartPage 78
SubjectTerms Addictions
Animals
Aversion
circuits
Cognition
Dopamine
Dopamine receptors
Dopaminergic Neurons - physiology
Forebrain
GABA
GABAergic Neurons - physiology
Motivation
Neural Inhibition - physiology
Neural Pathways - physiology
Neurons
Neuroscience
Physiology
Reinforcement
Reward
stress
Stress, Psychological - physiopathology
ventral tegmental area (VTA)
Ventral Tegmental Area - physiology
Ventral tegmentum
γ-Aminobutyric acid
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