Endometriosis-Associated Angiogenesis and Anti-angiogenic Therapy for Endometriosis

Endometriosis is a known estrogen-dependent inflammatory disease affecting reproductive-aged women. Common symptoms include pelvic pain, dysmenorrhea, dyspareunia, heavy menstrual bleeding, and infertility. The exact etiology of endometriosis is largely unknown, and, thus, the diagnosis and treatmen...

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Published in:Frontiers in Global Women's Health Vol. 3; p. 856316
Main Authors: Chung, Monica S., Han, Sang Jun
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media SA 05.04.2022
Frontiers Media S.A
Subjects:
Agonists
Angiogenesis
anti-angiogenic therapy
Apoptosis
Blood vessels
Bone marrow
Cytokines
Endometriosis
Endometrium
estrogen receptors
Estrogens
Global Women's Health
Hypoxia
Inflammation
Inflammatory diseases
Kinases
Medical prognosis
Menstruation
Pathogenesis
Proteins
Side effects
Vascular endothelial growth factor
Womens health
endometriosis
anti-angiogenic therapy
estrogen receptors
angiogenesis
vascular endothelial growth factor
ISSN:2673-5059, 2673-5059
Online Access:Get full text
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Summary:Endometriosis is a known estrogen-dependent inflammatory disease affecting reproductive-aged women. Common symptoms include pelvic pain, dysmenorrhea, dyspareunia, heavy menstrual bleeding, and infertility. The exact etiology of endometriosis is largely unknown, and, thus, the diagnosis and treatment of endometriosis are challenging. A complex interplay of many molecular mechanisms is thought to aid in the progression of endometriosis, most notably angiogenesis. This mini-review examines our current knowledge of the molecular etiology of endometriosis-associated angiogenesis and discusses anti-angiogenic therapy, in the blockade of endometriosis-associated angiogenesis, as potential non-hormonal therapy for the treatment of endometriosis.
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This article was submitted to Quality of Life, a section of the journal Frontiers in Global Women's Health
Reviewed by: Domenico Ribatti, University of Bari Aldo Moro, Italy; Megha Mistry, Norfolk and Norwich University Hospital, United Kingdom
Edited by: Thomas G. Gray, Norfolk and Norwich University Hospital, United Kingdom
ISSN:2673-5059
2673-5059
DOI:10.3389/fgwh.2022.856316