The Role of BDNF on Neural Plasticity in Depression

Using behavioral, pharmacological, and molecular methods, lots of studies reveal that depression is closely related to the abnormal neural plasticity processes occurring in the prefrontal cortex and limbic system such as the hippocampus and amygdala. Meanwhile, functions of the brain-derived neurotr...

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Published in:	Frontiers in cellular neuroscience Vol. 14; p. 82
Main Authors:	Yang, Tao, Nie, Zheng, Shu, Haifeng, Kuang, Yongqin, Chen, Xin, Cheng, Jingmin, Yu, Sixun, Liu, Huiying
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Research Foundation 15.04.2020 Frontiers Media S.A
Subjects:	Amygdala Apoptosis BDNF Behavioral plasticity Brain-derived neurotrophic factor Cellular Neuroscience depression Drug therapy Gene expression Hypotheses Intracellular signalling Kinases Ligands Mental depression Neostriatum neural plasticity Neurogenesis Neurons Neurotrophic factors Phosphorylation Plasticity (neural) Prefrontal cortex Proteins Transcription neurogenesis depression BDNF neural plasticity neurotrophic factors
ISSN:	1662-5102, 1662-5102
Online Access:	Get full text
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Abstract	Using behavioral, pharmacological, and molecular methods, lots of studies reveal that depression is closely related to the abnormal neural plasticity processes occurring in the prefrontal cortex and limbic system such as the hippocampus and amygdala. Meanwhile, functions of the brain-derived neurotrophic factor (BDNF) and the other neurotrophins in the pathogenesis of depression are well known. The maladaptive neuroplastic in depression may be related to alterations in the levels of neurotrophic factors, which play a central role in plasticity. Enhancement of neurotrophic factors signaling has great potential in therapy for depression. This review highlights the relevance of neurotrophic factors mediated neural plasticity and pathophysiology of depression. These studies reviewed here may suggest new possible targets for antidepressant drugs such as neurotrophins, their receptors, and relevant signaling pathways, and agents facilitating the activation of gene expression and increasing the transcription of neurotrophic factors in the brain.
AbstractList	Recent studies combining pharmacological, behavioral, electrophysiological and molecular approaches indicate that depression results from maladaptive neuroplastic processes occurring in defined frontolimbic circuits responsible for emotional processing such as the prefrontal cortex, hippocampus, amygdala and ventral striatum. Meanwhile, the role of the brain-derived neurotrophic factor and the other neurotrophins in the pathophysiology of depression is well known. The abnormal neural plasticity in depression may be related to alterations in the levels of neurotrophic factors, which play a central role in plasticity. Enhancement of neurotrophic factors signaling has great potential in therapy for depression. This review highlights the relevance of neurotrophic factors mediated neural plasticity and pathophysiology of depression. These studies reviewed here may suggest new possible targets for the pharmacotherapy of depression such as neurotrophic factors, their receptors and related intracellular signaling cascades, and agents facilitating the activation of gene expression and increasing the transcription of neurotrophins in the brain. Using behavioral, pharmacological, and molecular methods, lots of studies reveal that depression is closely related to the abnormal neural plasticity processes occurring in the prefrontal cortex and limbic system such as the hippocampus and amygdala. Meanwhile, functions of the brain-derived neurotrophic factor (BDNF) and the other neurotrophins in the pathogenesis of depression are well known. The maladaptive neuroplastic in depression may be related to alterations in the levels of neurotrophic factors, which play a central role in plasticity. Enhancement of neurotrophic factors signaling has great potential in therapy for depression. This review highlights the relevance of neurotrophic factors mediated neural plasticity and pathophysiology of depression. These studies reviewed here may suggest new possible targets for antidepressant drugs such as neurotrophins, their receptors, and relevant signaling pathways, and agents facilitating the activation of gene expression and increasing the transcription of neurotrophic factors in the brain. Using behavioral, pharmacological, and molecular methods, lots of studies reveal that depression is closely related to the abnormal neural plasticity processes occurring in the prefrontal cortex and limbic system such as the hippocampus and amygdala. Meanwhile, functions of the brain-derived neurotrophic factor (BDNF) and the other neurotrophins in the pathogenesis of depression are well known. The maladaptive neuroplastic in depression may be related to alterations in the levels of neurotrophic factors, which play a central role in plasticity. Enhancement of neurotrophic factors signaling has great potential in therapy for depression. This review highlights the relevance of neurotrophic factors mediated neural plasticity and pathophysiology of depression. These studies reviewed here may suggest new possible targets for antidepressant drugs such as neurotrophins, their receptors, and relevant signaling pathways, and agents facilitating the activation of gene expression and increasing the transcription of neurotrophic factors in the brain.Using behavioral, pharmacological, and molecular methods, lots of studies reveal that depression is closely related to the abnormal neural plasticity processes occurring in the prefrontal cortex and limbic system such as the hippocampus and amygdala. Meanwhile, functions of the brain-derived neurotrophic factor (BDNF) and the other neurotrophins in the pathogenesis of depression are well known. The maladaptive neuroplastic in depression may be related to alterations in the levels of neurotrophic factors, which play a central role in plasticity. Enhancement of neurotrophic factors signaling has great potential in therapy for depression. This review highlights the relevance of neurotrophic factors mediated neural plasticity and pathophysiology of depression. These studies reviewed here may suggest new possible targets for antidepressant drugs such as neurotrophins, their receptors, and relevant signaling pathways, and agents facilitating the activation of gene expression and increasing the transcription of neurotrophic factors in the brain.
Author	Chen, Xin Cheng, Jingmin Liu, Huiying Yang, Tao Nie, Zheng Kuang, Yongqin Shu, Haifeng Yu, Sixun
AuthorAffiliation	3 Department of Respiratory and Critical Care Diseases, The Fifth Medical Center of PLA General Hospital , Beijing , China 1 Department of Neurosurgery, The General Hospital of Western Theater Command , Chengdu , China 2 Department of Anatomy and Histology and Embryology, Regeneration Key Lab of Sichuan Province, Chengdu Medical College , Chengdu , China
AuthorAffiliation_xml	– name: 3 Department of Respiratory and Critical Care Diseases, The Fifth Medical Center of PLA General Hospital , Beijing , China – name: 2 Department of Anatomy and Histology and Embryology, Regeneration Key Lab of Sichuan Province, Chengdu Medical College , Chengdu , China – name: 1 Department of Neurosurgery, The General Hospital of Western Theater Command , Chengdu , China
Author_xml	– sequence: 1 givenname: Tao surname: Yang fullname: Yang, Tao – sequence: 2 givenname: Zheng surname: Nie fullname: Nie, Zheng – sequence: 3 givenname: Haifeng surname: Shu fullname: Shu, Haifeng – sequence: 4 givenname: Yongqin surname: Kuang fullname: Kuang, Yongqin – sequence: 5 givenname: Xin surname: Chen fullname: Chen, Xin – sequence: 6 givenname: Jingmin surname: Cheng fullname: Cheng, Jingmin – sequence: 7 givenname: Sixun surname: Yu fullname: Yu, Sixun – sequence: 8 givenname: Huiying surname: Liu fullname: Liu, Huiying
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/32351365$$D View this record in MEDLINE/PubMed
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Cites_doi	10.31887/DCNS.2014.16.1/rduman 10.1016/j.pnpbp.2019.109686 10.1016/0896-6273(92)90067-n 10.1176/appi.ajp.2012.12020248 10.1016/j.psychres.2013.12.009 10.1016/j.pharmthera.2009.06.001 10.1038/nn.2505 10.1002/jnr.21139 10.1016/j.biopsych.2011.06.006 10.3109/15622971003611319 10.1186/1756-6606-2-27 10.1126/science.1083328 10.1038/nn1659 10.1007/978-3-642-45106-5_17 10.1038/srep21222 10.1016/s0165-1781(02)00005-7 10.1523/JNEUROSCI.4998-12.2013 10.1007/978-3-642-45106-5_6 10.1097/jgp.0b013e318050c9d5 10.1002/dneu.20774 10.1073/pnas.0709102105 10.1073/pnas.1422336112 10.1016/j.tins.2012.12.010 10.1038/sj.npp.1300320 10.1016/j.nbd.2016.07.010 10.1523/jneurosci.16-07-02365.1996 10.1126/science.1129663 10.1016/s0959-4388(00)00092-1 10.1016/j.neuron.2015.04.007 10.3389/fnmol.2014.00094 10.1523/jneurosci.3741-04.2005 10.1016/s0006-3223(99)00230-9 10.1136/ebn.2011.100200 10.1523/jneurosci.22-05-01532.2002 10.1016/j.expneurol.2004.11.016 10.1186/s40345-019-0161-0 10.1523/jneurosci.15-11-07539.1995 10.1007/978-3-642-45106-5_2 10.1038/mp.2009.67 10.1007/978-3-642-45106-5_5 10.1038/mp.2012.187 10.1016/j.neuroscience.2005.12.058 10.1016/s0896-6273(02)00653-0 10.1096/fj.02-0143fje 10.1016/j.pnpbp.2008.10.005 10.1016/s0006-3223(01)01083-6 10.1038/npp.2008.208 10.1038/ncomms3490 10.1038/nn1969 10.1523/jneurosci.4297-06.2006 10.1016/j.jad.2015.09.021 10.1016/j.neuron.2014.03.021 10.1038/mp.2013.105 10.1002/dneu.20758 10.3389/fnbeh.2014.00143 10.1016/s0896-6273(00)80853-3 10.1016/j.ejphar.2015.12.029 10.1126/science.1100135 10.1016/j.neuroscience.2006.08.069 10.1177/1073858402238511 10.1038/nn.3237 10.1073/pnas.0337481100 10.1016/j.neuropharm.2015.10.034 10.1016/j.celrep.2014.10.016 10.31887/DCNS.2008.10.4/gracagni 10.1038/nature10130 10.1146/annurev.ne.19.030196.001445 10.1523/jneurosci.5123-04.2005 10.1126/science.1150516 10.1016/s0006-3223(99)00177-8 10.1016/j.biopsych.2011.09.030 10.1155/2017/6871089 10.1016/0166-2236(91)90097-e 10.1016/j.biopsych.2006.02.013 10.1126/science.1065057 10.1038/nn1971 10.1038/nn.2799 10.1523/jneurosci.5048-11.2012 10.1038/npp.2010.8 10.1074/jbc.m700607200 10.1073/pnas.0402141101 10.1016/s0893-133x(01)00358-x 10.1073/pnas.92.19.8856 10.1016/s0896-6273(02)00942-x 10.1016/s0028-3908(98)00035-5 10.1093/cercor/bhi104 10.1017/s1461145712000016 10.1523/jneurosci.4037-06.2007 10.1126/science.1222939 10.3390/ijms17030381 10.1073/pnas.0803702105 10.1371/journal.pone.0211241 10.1128/MCB.00150-13 10.1016/j.biopsych.2008.05.005 10.1124/pr.111.005108 10.1002/msj.20043 10.1523/JNEUROSCI.0119-10.2010 10.1038/npp.2010.114 10.1016/j.biopsych.2012.05.031 10.1098/rstb.2006.1894 10.1073/pnas.40.10.1014 10.1073/pnas.1015950108 10.1523/jneurosci.23-01-00349.2003 10.1016/j.neuropharm.2013.06.024 10.1016/j.biopsych.2006.03.082 10.1016/j.pharmthera.2011.05.007 10.1016/bs.vh.2016.10.004 10.1016/j.tins.2010.01.001 10.4088/JCP.08m04659 10.1016/j.jpsychires.2006.06.011 10.1016/s0092-8674(03)00035-7 10.1038/nn1510 10.1001/archpsyc.63.8.856 10.1083/jcb.201201038 10.1155/2013/318596 10.2165/11530010-000000000-00000 10.4088/JCP.11096su1c.01 10.1002/j.1460-2075.1982.tb01207.x 10.1111/j.1460-9568.2010.07486.x 10.1038/mp.2011.113 10.1017/S1461145713001119 10.1523/jneurosci.6034-11.2012 10.1523/jneurosci.1405-10.2010 10.1016/j.ygeno.2007.05.004 10.1002/dev.21297 10.1016/j.biopsych.2006.03.021 10.1126/science.1152864 10.1371/journal.pone.0094666 10.1016/j.biopsych.2007.09.019 10.1007/978-3-642-45106-5_1 10.1523/JNEUROSCI.22-08-03251.2002 10.1371/journal.pone.0115280 10.1038/nature07455 10.1111/j.1460-9568.2010.07488.x 10.1007/s12035-015-9569-4 10.1016/0014-5793(95)01520-5 10.1038/mp.2010.98 10.1016/j.neuropharm.2013.05.029 10.1101/lm.67804 10.1155/2012/631965 10.1038/nrn3379 10.1038/nature02319 10.1126/scisignal.2002060 10.1016/j.euroneuro.2013.12.010 10.1083/jcb.201504092 10.1152/jn.00797.2007
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Keywords	neurogenesis depression BDNF neural plasticity neurotrophic factors
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Specialty section: This article was submitted to Cellular Neurophysiology, a section of the journal Frontiers in Cellular Neuroscience Reviewed by: Ranji Cui, Second Affiliated Hospital of Jilin University, China; Bingjin Li, Jilin University, China; Wenbo Luo, Liaoning Normal University, China Edited by: Bin Song, McLean Hospital, United States These authors share first authorship
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References	Molteni (B96); 34 Verpelli (B141) 2010; 30 Deinhardt (B35) 2014; 220 Amaral (B6) 2007; 98 Radley (B115); 26 Saarelainen (B119) 2003; 23 Molendijk (B95) 2014; 19 Briz (B20) 2015; 210 Tanaka (B132) 2008; 319 Kaplan (B62) 2000; 10 Alcaide (B3) 2019; 7 Sairanen (B122) 2007; 144 Koshimizu (B69) 2009; 2 Castrén (B27); 24 Hempstead (B56) 2014; 220 Lee (B78) 2001; 294 Kuhn (B72) 2014; 9 Cohen (B32) 1954; 40 Erickson (B49) 2011; 108 Chan (B28) 2016; 189 Ninan (B104) 2010; 30 Duman (B42) 1999; 46 Bosch (B18) 2014; 82 Colla (B34) 2007; 41 Pang (B108) 2004; 306 Anastasia (B7) 2013; 4 Pruunsild (B113) 2007; 90 Frodl (B52) 2010; 35 Radley (B116); 16 Castrén (B25) 2017; 97 Thompson (B136) 2012; 15 Shirayama (B130) 2002; 22 Chen (B29) 2001; 50 Molteni (B97); 124 Lindholm (B80) 2014; 8 Luoni (B84) 2016; 53 Martinowich (B87) 2007; 10 Jeanneteau (B59) 2008; 105 Björkholm (B16) 2016; 102 Kuipers (B73) 2016; 6 Leal (B77) 2017; 104 Maya Vetencourt (B88) 2008; 320 Taliaz (B131) 2010; 15 Ji (B61) 2010; 13 Sen (B127) 2008; 75 Dwivedi (B45) 2006; 139 Hennings (B57) 2019; 95 Hirschfeld (B58) 2012; 73 Tzanoulinou (B140) 2014; 9 Laje (B75) 2012; 72 Banasr (B11) 2004; 29 Nibuya (B102) 1996; 16 Zagrebelsky (B145) 2014; 76 Chen (B30) 2011; 14 Tripp (B137) 2012; 169 Caldeira (B22) 2007; 282 Rex (B118) 2007; 27 Haile (B55) 2014; 17 Kasai (B64) 2010; 33 Autry (B10) 2012; 64 Castrén (B26); 70 MacQueen (B86) 2003; 100 Aid (B2) 2007; 85 Lai (B74) 2012; 15 Bergami (B13) 2008; 105 Dranovsky (B38) 2006; 59 Schmidt (B125) 2010; 35 Tyler (B139) 2002; 8 Sheline (B129) 2011; 70 Barde (B12) 1982; 1 Calabrese (B21) 2011; 132 Panja (B109) 2014; 76 Reichardt (B117) 2006; 361 Chen (B31) 2006; 314 Minichiello (B92) 1999; 24 Minichiello (B91) 2002; 36 Lambert (B76) 2013; 33 Sen (B128) 2008; 64 Autry (B9) 2011; 475 Nibuya (B101) 1995; 15 Karege (B63) 2002; 109 Berry (B15) 2015; 57 Cohen-Cory (B33) 2010; 70 Taylor (B133) 2007; 15 Duric (B44) 2013; 16 Nykjaer (B107) 2004; 427 Woo (B142) 2005; 8 Castrén (B23) 2014; 220 Dieni (B37) 2012; 196 Monteggia (B98) 2004; 101 Kaster (B65) 2016; 771 Tsankova (B138) 2006; 9 Castrén (B24) 2013; 36 Hagihara (B54) 2013; 2013 Bocchio-Chiavetto (B17) 2010; 11 Monteggia (B99) 2007; 61 Duman (B39) 2014; 16 Luoni (B83) 2014; 24 Nestler (B100) 2002; 34 Park (B111) 2013; 14 Niitsu (B103) 2014; 215 Guilloux (B53) 2012; 17 Nosyreva (B106) 2013; 33 Alonso (B5) 2004; 11 Feyissa (B50) 2009; 33 Ying (B143) 2002; 22 Mizui (B93) 2015; 112 Egan (B47) 2003; 112 Zarate (B146) 2006; 63 Katoh-Semba (B66) 2002; 16 Liu (B82) 2017; 2017 Korte (B67) 1995; 92 Korte (B68) 1998; 37 Bothwell (B19) 2014; 220 Molendijk (B94) 2011; 16 Lewin (B79) 1996; 19 Liu (B81) 2012; 71 Machado-Vieira (B85) 2009; 70 Panja (B110) 2014; 9 Racagni (B114) 2008; 10 Scharfman (B124) 2005; 192 Fortin (B51) 2012; 32 Aldoghachi (B4) 2019; 14 Duman (B40) 2012; 338 Adachi (B1) 2008; 63 Thoenen (B135) 1991; 14 Berman (B14) 2000; 47 Anderson (B8) 2011; 33 Yu (B144) 2012; 32 Krishnan (B71) 2008; 455 Teng (B134) 2005; 25 Duman (B43) 2001; 25 Eisenberg (B48) 2013; 18 Jeon (B60) 2016; 17 Nosyreva (B105) 2014; 7 Maya Vetencourt (B89) 2011; 33 Kraemer (B70) 2014; 220 Santarelli (B123) 2003; 301 Sahay (B120) 2007; 10 Maya-Vetencourt (B90) 2012; 2012 Deinhardt (B36) 2011; 4 Seidah (B126) 1996; 379 Duman (B41) 2006; 59 Patterson (B112) 1992; 9 Sairanen (B121) 2005; 25 Edelmann (B46) 2015; 86
References_xml	– volume: 16 start-page: 11 year: 2014 ident: B39 article-title: Pathophysiology of depression and innovative treatments: remodeling glutamatergic synaptic connections publication-title: Dialogues Clin. Neurosci. doi: 10.31887/DCNS.2014.16.1/rduman – volume: 95 start-page: 109686 year: 2019 ident: B57 article-title: Polymorphisms in the BDNF and BDNFOS genes are associated with hypothalamus-pituitary axis regulation in major depression publication-title: Prog. Neuropsychopharmacol. Biol. Psychiatry doi: 10.1016/j.pnpbp.2019.109686 – volume: 9 start-page: 1081 year: 1992 ident: B112 article-title: Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs publication-title: Neuron doi: 10.1016/0896-6273(92)90067-n – volume: 169 start-page: 1194 year: 2012 ident: B137 article-title: Brain-derived neurotrophic factor signaling and subgenual anterior cingulate cortex dysfunction in major depressive disorder publication-title: Am. J. Psychiatry doi: 10.1176/appi.ajp.2012.12020248 – volume: 215 start-page: 268 year: 2014 ident: B103 article-title: A positive correlation between serum levels of mature brain-derived neurotrophic factor and negative symptoms in schizophrenia publication-title: Psychiatry Res. doi: 10.1016/j.psychres.2013.12.009 – volume: 124 start-page: 74 ident: B97 article-title: Antipsychotic drug actions on gene modulation and signaling mechanisms publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2009.06.001 – volume: 13 start-page: 302 year: 2010 ident: B61 article-title: Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons publication-title: Nat. Neurosci. doi: 10.1038/nn.2505 – volume: 85 start-page: 525 year: 2007 ident: B2 article-title: Mouse and rat BDNF gene structure and expression revisited publication-title: J. Neurosci. Res. doi: 10.1002/jnr.21139 – volume: 70 start-page: 308 year: 2011 ident: B129 article-title: Depression and the hippocampus: cause or effect? publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2011.06.006 – volume: 11 start-page: 763 year: 2010 ident: B17 article-title: Serum and plasma BDNF levels in major depression: a replication study and meta-analyses publication-title: World J. Biol. Psychiatry doi: 10.3109/15622971003611319 – volume: 2 start-page: 27 year: 2009 ident: B69 article-title: Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival publication-title: Mol. Brain doi: 10.1186/1756-6606-2-27 – volume: 301 start-page: 805 year: 2003 ident: B123 article-title: Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants publication-title: Science doi: 10.1126/science.1083328 – volume: 9 start-page: 519 year: 2006 ident: B138 article-title: Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action publication-title: Nat. Neurosci. doi: 10.1038/nn1659 – volume: 220 start-page: 461 year: 2014 ident: B23 article-title: Neurotrophins and psychiatric disorders publication-title: Handb. Exp. Pharmacol. doi: 10.1007/978-3-642-45106-5_17 – volume: 6 start-page: 21222 year: 2016 ident: B73 article-title: BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis publication-title: Sci. Rep. doi: 10.1038/srep21222 – volume: 109 start-page: 143 year: 2002 ident: B63 article-title: Decreased serum brain-derived neurotrophic factor levels in major depressed patients publication-title: Psychiatry Res. doi: 10.1016/s0165-1781(02)00005-7 – volume: 33 start-page: 6990 year: 2013 ident: B106 article-title: Acute suppression of spontaneous neurotransmission drives synaptic potentiation publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.4998-12.2013 – volume: 220 start-page: 121 year: 2014 ident: B70 article-title: The biological functions and signaling mechanisms of the p75 neurotrophin receptor publication-title: Handb. Exp. Pharmacol. doi: 10.1007/978-3-642-45106-5_6 – volume: 15 start-page: 850 year: 2007 ident: B133 article-title: Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression publication-title: Am. J. Geriatr. Psychiatry doi: 10.1097/jgp.0b013e318050c9d5 – volume: 70 start-page: 271 year: 2010 ident: B33 article-title: Brain-derived neurotrophic factor and the development of structural neuronal connectivity publication-title: Dev. Neurobiol. doi: 10.1002/dneu.20774 – volume: 105 start-page: 4862 year: 2008 ident: B59 article-title: Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.0709102105 – volume: 112 start-page: E3067 year: 2015 ident: B93 article-title: BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.1422336112 – volume: 36 start-page: 259 year: 2013 ident: B24 article-title: Neuronal plasticity and antidepressant actions publication-title: Trends Neurosci. doi: 10.1016/j.tins.2012.12.010 – volume: 29 start-page: 450 year: 2004 ident: B11 article-title: Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1300320 – volume: 97 start-page: 119 year: 2017 ident: B25 article-title: Brain-derived neurotrophic factor in mood disorders and antidepressant treatments publication-title: Neurobiol. Dis. doi: 10.1016/j.nbd.2016.07.010 – volume: 16 start-page: 2365 year: 1996 ident: B102 article-title: Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus publication-title: J. Neurosci. doi: 10.1523/jneurosci.16-07-02365.1996 – volume: 314 start-page: 140 year: 2006 ident: B31 article-title: Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior publication-title: Science doi: 10.1126/science.1129663 – volume: 10 start-page: 381 year: 2000 ident: B62 article-title: Neurotrophin signal transduction in the nervous system publication-title: Curr. Opin. Neurobiol. doi: 10.1016/s0959-4388(00)00092-1 – volume: 86 start-page: 1041 year: 2015 ident: B46 article-title: Theta burst firing recruits BDNF release and signaling in postsynaptic CA1 neurons in spike-timing-dependent LTP publication-title: Neuron doi: 10.1016/j.neuron.2015.04.007 – volume: 7 start-page: 94 year: 2014 ident: B105 article-title: Age dependence of the rapid antidepressant and synaptic effects of acute NMDA receptor blockade publication-title: Front. Mol. Neurosci. doi: 10.3389/fnmol.2014.00094 – volume: 25 start-page: 1089 year: 2005 ident: B121 article-title: Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation and survival in the adult dentate gyrus publication-title: J. Neurosci. doi: 10.1523/jneurosci.3741-04.2005 – volume: 47 start-page: 351 year: 2000 ident: B14 article-title: Antidepressant effects of ketamine in depressed patients publication-title: Biol. Psychiatry doi: 10.1016/s0006-3223(99)00230-9 – volume: 15 start-page: 35 year: 2012 ident: B136 article-title: Motivational interviewing improves patients’ mood and reduces mortality 12 months poststroke publication-title: Evid. Based Nurs. doi: 10.1136/ebn.2011.100200 – volume: 22 start-page: 1532 year: 2002 ident: B143 article-title: Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis publication-title: J. Neurosci. doi: 10.1523/jneurosci.22-05-01532.2002 – volume: 192 start-page: 348 year: 2005 ident: B124 article-title: Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats publication-title: Exp. Neurol. doi: 10.1016/j.expneurol.2004.11.016 – volume: 7 start-page: 24 year: 2019 ident: B3 article-title: Alterations of perineuronal nets in the dorsolateral prefrontal cortex of neuropsychiatric patients publication-title: Int. J. Bipolar Disord. doi: 10.1186/s40345-019-0161-0 – volume: 15 start-page: 7539 year: 1995 ident: B101 article-title: Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments publication-title: J. Neurosci. doi: 10.1523/jneurosci.15-11-07539.1995 – volume: 220 start-page: 17 year: 2014 ident: B56 article-title: Deciphering proneurotrophin actions publication-title: Handb. Exp. Pharmacol. doi: 10.1007/978-3-642-45106-5_2 – volume: 15 start-page: 80 year: 2010 ident: B131 article-title: Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis publication-title: Mol. Psychiatry doi: 10.1038/mp.2009.67 – volume: 220 start-page: 103 year: 2014 ident: B35 article-title: Trk receptors publication-title: Handb. Exp. Pharmacol. doi: 10.1007/978-3-642-45106-5_5 – volume: 18 start-page: 713 year: 2013 ident: B48 article-title: Brain-derived neurotrophic factor (BDNF) Val(66)Met polymorphism differentially predicts hippocampal function in medication-free patients with schizophrenia publication-title: Mol. Psychiatry doi: 10.1038/mp.2012.187 – volume: 139 start-page: 1017 year: 2006 ident: B45 article-title: Antidepressants reverse corticosterone-mediated decrease in brain-derived neurotrophic factor expression: differential regulation of specific exons by antidepressants and corticosterone publication-title: Neuroscience doi: 10.1016/j.neuroscience.2005.12.058 – volume: 34 start-page: 13 year: 2002 ident: B100 article-title: Neurobiology of depression publication-title: Neuron doi: 10.1016/s0896-6273(02)00653-0 – volume: 16 start-page: 1328 year: 2002 ident: B66 article-title: Riluzole enhances expression of brain-derived neurotrophic factor with consequent proliferation of granule precursor cells in the rat hippocampus publication-title: FASEB J. doi: 10.1096/fj.02-0143fje – volume: 33 start-page: 70 year: 2009 ident: B50 article-title: Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression publication-title: Prog. Neuropsychopharmacol. Biol. Psychiatry doi: 10.1016/j.pnpbp.2008.10.005 – volume: 50 start-page: 260 year: 2001 ident: B29 article-title: Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication publication-title: Biol. Psychiatry doi: 10.1016/s0006-3223(01)01083-6 – volume: 34 start-page: 1523 ident: B96 article-title: Acute stress responsiveness of the neurotrophin BDNF in the rat hippocampus is modulated by chronic treatment with the antidepressant duloxetine publication-title: Neuropsychopharmacology doi: 10.1038/npp.2008.208 – volume: 4 start-page: 2490 year: 2013 ident: B7 article-title: Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction publication-title: Nat. Commun. doi: 10.1038/ncomms3490 – volume: 10 start-page: 1110 year: 2007 ident: B120 article-title: Adult hippocampal neurogenesis in depression publication-title: Nat. Neurosci. doi: 10.1038/nn1969 – volume: 26 start-page: 12967 ident: B115 article-title: Regional differentiation of the medial prefrontal cortex in regulating adaptive responses to acute emotional stress publication-title: J. Neurosci. doi: 10.1523/jneurosci.4297-06.2006 – volume: 189 start-page: 199 year: 2016 ident: B28 article-title: Hippocampal volume in vulnerability and resilience to depression publication-title: J. Affect. Disord. doi: 10.1016/j.jad.2015.09.021 – volume: 82 start-page: 444 year: 2014 ident: B18 article-title: Structural and molecular remodeling of dendritic spine substructures during long-term potentiation publication-title: Neuron doi: 10.1016/j.neuron.2014.03.021 – volume: 19 start-page: 791 year: 2014 ident: B95 article-title: Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N=9484) publication-title: Mol. Psychiatry doi: 10.1038/mp.2013.105 – volume: 70 start-page: 289 ident: B26 article-title: The role of BDNF and its receptors in depression and antidepressant drug action: reactivation of developmental plasticity publication-title: Dev. Neurobiol. doi: 10.1002/dneu.20758 – volume: 8 start-page: 143 year: 2014 ident: B80 article-title: Mice with altered BDNF signaling as models for mood disorders and antidepressant effects publication-title: Front. Behav. Neurosci. doi: 10.3389/fnbeh.2014.00143 – volume: 24 start-page: 401 year: 1999 ident: B92 article-title: Essential role for TrkB receptors in hippocampus-mediated learning publication-title: Neuron doi: 10.1016/s0896-6273(00)80853-3 – volume: 771 start-page: 236 year: 2016 ident: B65 article-title: Novel approaches for the management of depressive disorders publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2015.12.029 – volume: 306 start-page: 487 year: 2004 ident: B108 article-title: Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity publication-title: Science doi: 10.1126/science.1100135 – volume: 144 start-page: 368 year: 2007 ident: B122 article-title: Chronic antidepressant treatment selectively increases expression of plasticity-related proteins in the hippocampus and medial prefrontal cortex of the rat publication-title: Neuroscience doi: 10.1016/j.neuroscience.2006.08.069 – volume: 8 start-page: 524 year: 2002 ident: B139 article-title: The role of neurotrophins in neurotransmitter release publication-title: Neuroscientist doi: 10.1177/1073858402238511 – volume: 15 start-page: 1506 year: 2012 ident: B74 article-title: TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory publication-title: Nat. Neurosci. doi: 10.1038/nn.3237 – volume: 100 start-page: 1387 year: 2003 ident: B86 article-title: Course of illness, hippocampal function, and hippocampal volume in major depression publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.0337481100 – volume: 102 start-page: 72 year: 2016 ident: B16 article-title: BDNF–a key transducer of antidepressant effects publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2015.10.034 – volume: 9 start-page: 1430 year: 2014 ident: B110 article-title: Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK publication-title: Cell Rep. doi: 10.1016/j.celrep.2014.10.016 – volume: 10 start-page: 385 year: 2008 ident: B114 article-title: Cellular and molecular mechanisms in the long-term action of antidepressants publication-title: Dialogues Clin. Neurosci. doi: 10.31887/DCNS.2008.10.4/gracagni – volume: 475 start-page: 91 year: 2011 ident: B9 article-title: NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses publication-title: Nature doi: 10.1038/nature10130 – volume: 19 start-page: 289 year: 1996 ident: B79 article-title: Physiology of the neurotrophins publication-title: Annu. Rev. Neurosci. doi: 10.1146/annurev.ne.19.030196.001445 – volume: 25 start-page: 5455 year: 2005 ident: B134 article-title: ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin publication-title: J. Neurosci. doi: 10.1523/jneurosci.5123-04.2005 – volume: 320 start-page: 385 year: 2008 ident: B88 article-title: The antidepressant fluoxetine restores plasticity in the adult visual cortex publication-title: Science doi: 10.1126/science.1150516 – volume: 46 start-page: 1181 year: 1999 ident: B42 article-title: Neural plasticity to stress and antidepressant treatment publication-title: Biol. Psychiatry doi: 10.1016/s0006-3223(99)00177-8 – volume: 71 start-page: 996 year: 2012 ident: B81 article-title: Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2011.09.030 – volume: 2017 start-page: 6871089 year: 2017 ident: B82 article-title: The role of neural plasticity in depression: from hippocampus to prefrontal cortex publication-title: Neural Plast. doi: 10.1155/2017/6871089 – volume: 14 start-page: 165 year: 1991 ident: B135 article-title: The changing scene of neurotrophic factors publication-title: Trends Neurosci. doi: 10.1016/0166-2236(91)90097-e – volume: 59 start-page: 1116 year: 2006 ident: B41 article-title: A neurotrophic model for stress-related mood disorders publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2006.02.013 – volume: 294 start-page: 1945 year: 2001 ident: B78 article-title: Regulation of cell survival by secreted proneurotrophins publication-title: Science doi: 10.1126/science.1065057 – volume: 10 start-page: 1089 year: 2007 ident: B87 article-title: New insights into BDNF function in depression and anxiety publication-title: Nat. Neurosci. doi: 10.1038/nn1971 – volume: 14 start-page: 587 year: 2011 ident: B30 article-title: Structural basis for the role of inhibition in facilitating adult brain plasticity publication-title: Nat. Neurosci. doi: 10.1038/nn.2799 – volume: 32 start-page: 4092 year: 2012 ident: B144 article-title: Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants publication-title: J. Neurosci. doi: 10.1523/jneurosci.5048-11.2012 – volume: 35 start-page: 1383 year: 2010 ident: B52 article-title: Childhood stress, serotonin transporter gene and brain structures in major depression publication-title: Neuropsychopharmacology doi: 10.1038/npp.2010.8 – volume: 282 start-page: 12619 year: 2007 ident: B22 article-title: Brain-derived neurotrophic factor regulates the expression and synaptic delivery of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons publication-title: J. Biol. Chem. doi: 10.1074/jbc.m700607200 – volume: 101 start-page: 10827 year: 2004 ident: B98 article-title: Essential role of brain-derived neurotrophic factor in adult hippocampal function publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.0402141101 – volume: 25 start-page: 836 year: 2001 ident: B43 article-title: Regulation of adult neurogenesis by antidepressant treatment publication-title: Neuropsychopharmacology doi: 10.1016/s0893-133x(01)00358-x – volume: 92 start-page: 8856 year: 1995 ident: B67 article-title: Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.92.19.8856 – volume: 36 start-page: 121 year: 2002 ident: B91 article-title: Mechanism of TrkB-mediated hippocampal long-term potentiation publication-title: Neuron doi: 10.1016/s0896-6273(02)00942-x – volume: 37 start-page: 553 year: 1998 ident: B68 article-title: A role for BDNF in the late-phase of hippocampal long-term potentiation publication-title: Neuropharmacology doi: 10.1016/s0028-3908(98)00035-5 – volume: 16 start-page: 313 ident: B116 article-title: Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex publication-title: Cereb. Cortex doi: 10.1093/cercor/bhi104 – volume: 16 start-page: 69 year: 2013 ident: B44 article-title: Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects publication-title: Int. J. Neuropsychopharmacol. doi: 10.1017/s1461145712000016 – volume: 27 start-page: 3017 year: 2007 ident: B118 article-title: Brain-derived neurotrophic factor promotes long-term potentiation-related cytoskeletal changes in adult hippocampus publication-title: J. Neurosci. doi: 10.1523/jneurosci.4037-06.2007 – volume: 338 start-page: 68 year: 2012 ident: B40 article-title: Synaptic dysfunction in depression: potential therapeutic targets publication-title: Science doi: 10.1126/science.1222939 – volume: 17 start-page: 381 year: 2016 ident: B60 article-title: Molecular neurobiology and promising new treatment in depression publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms17030381 – volume: 105 start-page: 15570 year: 2008 ident: B13 article-title: Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.0803702105 – volume: 14 start-page: e0211241 year: 2019 ident: B4 article-title: Screening of brain-derived neurotrophic factor (BDNF) single nucleotide polymorphisms and plasma BDNF levels among Malaysian major depressive disorder patients publication-title: PLoS One doi: 10.1371/journal.pone.0211241 – volume: 33 start-page: 3700 year: 2013 ident: B76 article-title: Brain-derived neurotrophic factor signaling rewrites the glucocorticoid transcriptome via glucocorticoid receptor phosphorylation publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.00150-13 – volume: 64 start-page: 527 year: 2008 ident: B128 article-title: Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2008.05.005 – volume: 64 start-page: 238 year: 2012 ident: B10 article-title: Brain-derived neurotrophic factor and neuropsychiatric disorders publication-title: Pharmacol. Rev. doi: 10.1124/pr.111.005108 – volume: 75 start-page: 204 year: 2008 ident: B127 article-title: Major depression: emerging therapeutics publication-title: Mt. Sinai J. Med. doi: 10.1002/msj.20043 – volume: 30 start-page: 5830 year: 2010 ident: B141 article-title: Synaptic activity controls dendritic spine morphology by modulating eEF2-dependent BDNF synthesis publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.0119-10.2010 – volume: 35 start-page: 2378 year: 2010 ident: B125 article-title: Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models publication-title: Neuropsychopharmacology doi: 10.1038/npp.2010.114 – volume: 72 start-page: e27 year: 2012 ident: B75 article-title: Brain-derived neurotrophic factor Val66Met polymorphism and antidepressant efficacy of ketamine in depressed patients publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2012.05.031 – volume: 361 start-page: 1545 year: 2006 ident: B117 article-title: Neurotrophin-regulated signalling pathways publication-title: Philos. Trans. R. Soc. Lond. B Biol. Sci. doi: 10.1098/rstb.2006.1894 – volume: 40 start-page: 1014 year: 1954 ident: B32 article-title: A nerve growth-stimulating factor isolated from sarcom as 37 and 180 publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.40.10.1014 – volume: 108 start-page: 3017 year: 2011 ident: B49 article-title: Exercise training increases size of hippocampus and improves memory publication-title: Proc. Natl. Acad. Sci. U S A doi: 10.1073/pnas.1015950108 – volume: 23 start-page: 349 year: 2003 ident: B119 article-title: Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects publication-title: J. Neurosci. doi: 10.1523/jneurosci.23-01-00349.2003 – volume: 76 start-page: 664 year: 2014 ident: B109 article-title: BDNF mechanisms in late LTP formation: a synthesis and breakdown publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2013.06.024 – volume: 59 start-page: 1136 year: 2006 ident: B38 article-title: Hippocampal neurogenesis: regulation by stress and antidepressants publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2006.03.082 – volume: 132 start-page: 39 year: 2011 ident: B21 article-title: Antistress properties of antidepressant drugs and their clinical implications publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2011.05.007 – volume: 104 start-page: 153 year: 2017 ident: B77 article-title: BDNF and hippocampal synaptic plasticity publication-title: Vitam. Horm. doi: 10.1016/bs.vh.2016.10.004 – volume: 33 start-page: 121 year: 2010 ident: B64 article-title: Structural dynamics of dendritic spines in memory and cognition publication-title: Trends Neurosci. doi: 10.1016/j.tins.2010.01.001 – volume: 70 start-page: 1662 year: 2009 ident: B85 article-title: Brain-derived neurotrophic factor and initial antidepressant response to an N-methyl-D-aspartate antagonist publication-title: J. Clin. Psychiatry doi: 10.4088/JCP.08m04659 – volume: 41 start-page: 553 year: 2007 ident: B34 article-title: Hippocampal volume reduction and HPA-system activity in major depression publication-title: J. Psychiatr. Res. doi: 10.1016/j.jpsychires.2006.06.011 – volume: 112 start-page: 257 year: 2003 ident: B47 article-title: The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function publication-title: Cell doi: 10.1016/s0092-8674(03)00035-7 – volume: 8 start-page: 1069 year: 2005 ident: B142 article-title: Activation of p75NTR by proBDNF facilitates hippocampal long-term depression publication-title: Nat. Neurosci. doi: 10.1038/nn1510 – volume: 63 start-page: 856 year: 2006 ident: B146 article-title: A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.63.8.856 – volume: 196 start-page: 775 year: 2012 ident: B37 article-title: BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons publication-title: J. Cell Biol. doi: 10.1083/jcb.201201038 – volume: 2013 start-page: 318596 year: 2013 ident: B54 article-title: Immature dentate gyrus: an endophenotype of neuropsychiatric disorders publication-title: Neural Plast. doi: 10.1155/2013/318596 – volume: 24 start-page: 1 ident: B27 article-title: Role of brain-derived neurotrophic factor in the aetiology of depression: implications for pharmacological treatment publication-title: CNS Drugs doi: 10.2165/11530010-000000000-00000 – volume: 73 start-page: 5 year: 2012 ident: B58 article-title: The epidemiology of depression and the evolution of treatment publication-title: J. Clin. Psychiatry doi: 10.4088/JCP.11096su1c.01 – volume: 1 start-page: 549 year: 1982 ident: B12 article-title: Purification of a new neurotrophic factor from mammalian brain publication-title: EMBO J. doi: 10.1002/j.1460-2075.1982.tb01207.x – volume: 33 start-page: 175 year: 2011 ident: B8 article-title: Associative learning increases adult neurogenesis during a critical period publication-title: Eur. J. Neurosci. doi: 10.1111/j.1460-9568.2010.07486.x – volume: 17 start-page: 1130 year: 2012 ident: B53 article-title: Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression publication-title: Mol. Psychiatry doi: 10.1038/mp.2011.113 – volume: 17 start-page: 331 year: 2014 ident: B55 article-title: Plasma brain derived neurotrophic factor (BDNF) and response to ketamine in treatment-resistant depression publication-title: Int. J. Neuropsychopharmacol. doi: 10.1017/S1461145713001119 – volume: 32 start-page: 8127 year: 2012 ident: B51 article-title: Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors publication-title: J. Neurosci. doi: 10.1523/jneurosci.6034-11.2012 – volume: 30 start-page: 8866 year: 2010 ident: B104 article-title: The BDNF Val66Met polymorphism impairs NMDA receptor-dependent synaptic plasticity in the hippocampus publication-title: J. Neurosci. doi: 10.1523/jneurosci.1405-10.2010 – volume: 90 start-page: 397 year: 2007 ident: B113 article-title: Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters publication-title: Genomics doi: 10.1016/j.ygeno.2007.05.004 – volume: 57 start-page: 365 year: 2015 ident: B15 article-title: Decreased Bdnf expression and reduced social behavior in periadolescent rats following prenatal stress publication-title: Dev. Psychobiol. doi: 10.1002/dev.21297 – volume: 61 start-page: 187 year: 2007 ident: B99 article-title: Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2006.03.021 – volume: 319 start-page: 1683 year: 2008 ident: B132 article-title: Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines publication-title: Science doi: 10.1126/science.1152864 – volume: 9 start-page: e94666 year: 2014 ident: B140 article-title: Long-term behavioral programming induced by peripuberty stress in rats is accompanied by GABAergic-related alterations in the Amygdala publication-title: PLoS One doi: 10.1371/journal.pone.0094666 – volume: 63 start-page: 642 year: 2008 ident: B1 article-title: Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2007.09.019 – volume: 220 start-page: 3 year: 2014 ident: B19 article-title: NGF, BDNF, NT3, and NT4 publication-title: Handb. Exp. Pharmacol. doi: 10.1007/978-3-642-45106-5_1 – volume: 22 start-page: 3251 year: 2002 ident: B130 article-title: Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.22-08-03251.2002 – volume: 9 start-page: e115280 year: 2014 ident: B72 article-title: Fear extinction as a model for synaptic plasticity in major depressive disorder publication-title: PLoS One doi: 10.1371/journal.pone.0115280 – volume: 455 start-page: 894 year: 2008 ident: B71 article-title: The molecular neurobiology of depression publication-title: Nature doi: 10.1038/nature07455 – volume: 33 start-page: 49 year: 2011 ident: B89 article-title: Serotonin triggers a transient epigenetic mechanism that reinstates adult visual cortex plasticity in rats publication-title: Eur. J. Neurosci. doi: 10.1111/j.1460-9568.2010.07488.x – volume: 53 start-page: 7037 year: 2016 ident: B84 article-title: Sex-specific effects of prenatal stress on Bdnf expression in response to an acute challenge in rats: a role for Gadd45β publication-title: Mol. Neurobiol. doi: 10.1007/s12035-015-9569-4 – volume: 379 start-page: 247 year: 1996 ident: B126 article-title: Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases publication-title: FEBS Lett. doi: 10.1016/0014-5793(95)01520-5 – volume: 16 start-page: 1088 year: 2011 ident: B94 article-title: Serum levels of brain-derived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment publication-title: Mol. Psychiatry doi: 10.1038/mp.2010.98 – volume: 76 start-page: 628 year: 2014 ident: B145 article-title: Form follows function: BDNF and its involvement in sculpting the function and structure of synapses publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2013.05.029 – volume: 11 start-page: 172 year: 2004 ident: B5 article-title: ERK1/2 activation is necessary for BDNF to increase dendritic spine density in hippocampal CA1 pyramidal neurons publication-title: Learn. Mem. doi: 10.1101/lm.67804 – volume: 2012 start-page: 631965 year: 2012 ident: B90 article-title: Visual cortex plasticity: a complex interplay of genetic and environmental influences publication-title: Neural Plast. doi: 10.1155/2012/631965 – volume: 14 start-page: 7 year: 2013 ident: B111 article-title: Neurotrophin regulation of neural circuit development and function publication-title: Nat. Rev. Neurosci. doi: 10.1038/nrn3379 – volume: 427 start-page: 843 year: 2004 ident: B107 article-title: Sortilin is essential for proNGF-induced neuronal cell death publication-title: Nature doi: 10.1038/nature02319 – volume: 4 start-page: ra82 year: 2011 ident: B36 article-title: Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac publication-title: Sci. Signal. doi: 10.1126/scisignal.2002060 – volume: 24 start-page: 986 year: 2014 ident: B83 article-title: Delayed BDNF alterations in the prefrontal cortex of rats exposed to prenatal stress: preventive effect of lurasidone treatment during adolescence publication-title: Eur. Neuropsychopharmacol. doi: 10.1016/j.euroneuro.2013.12.010 – volume: 210 start-page: 1225 year: 2015 ident: B20 article-title: A novel form of synaptic plasticity in field CA3 of hippocampus requires GPER1 activation and BDNF release publication-title: J. Cell Biol. doi: 10.1083/jcb.201504092 – volume: 98 start-page: 2476 year: 2007 ident: B6 article-title: BDNF induces calcium elevations associated with IBDNF, a nonselective cationic current mediated by TRPC channels publication-title: J. Neurophysiol. doi: 10.1152/jn.00797.2007
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Snippet	Using behavioral, pharmacological, and molecular methods, lots of studies reveal that depression is closely related to the abnormal neural plasticity processes... Recent studies combining pharmacological, behavioral, electrophysiological and molecular approaches indicate that depression results from maladaptive...
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SubjectTerms	Amygdala Apoptosis BDNF Behavioral plasticity Brain-derived neurotrophic factor Cellular Neuroscience depression Drug therapy Gene expression Hypotheses Intracellular signalling Kinases Ligands Mental depression Neostriatum neural plasticity Neurogenesis Neurons Neurotrophic factors Phosphorylation Plasticity (neural) Prefrontal cortex Proteins Transcription
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Title	The Role of BDNF on Neural Plasticity in Depression
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Volume	14
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