The pharmacokinetics and toxicity of morning vs. evening tobramycin dosing for pulmonary exacerbations of cystic fibrosis: A randomised comparison

Circadian variation in renal toxicity of aminoglycosides has been demonstrated in animal and human studies. People with CF are frequently prescribed aminoglycosides. Altered pharmacokinetics of aminoglycosides are predictive of toxicity. To investigate whether the time of day of aminoglycoside admin...

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Bibliographic Details
Published in:	Journal of cystic fibrosis Vol. 15; no. 4; pp. 510 - 517
Main Authors:	Prayle, A.P., Jain, K., Touw, D.J., Koch, B.C.P., Knox, A.J., Watson, A., Smyth, A.R.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.07.2016 Elsevier
Subjects:	Adolescent Aminoglycosides Aminoglycosides - administration & dosage Aminoglycosides - adverse effects Aminoglycosides - pharmacokinetics Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - pharmacokinetics Child Circadian rhythm Circadian Rhythm - physiology Cystic fibrosis Cystic Fibrosis - drug therapy Drug Administration Schedule Drug Chronotherapy Drug Monitoring - methods Female Hepatitis A Virus Cellular Receptor 1 - analysis Humans Kidney - drug effects Kidney - metabolism Male Melatonin - analysis Original Pulmonary/Respiratory Renal Elimination - physiology Tobramycin - administration & dosage Tobramycin - adverse effects Tobramycin - pharmacokinetics Toxicity Treatment Outcome Urinalysis - methods Cystic fibrosis Aminoglycosides Circadian rhythm Toxicity
ISSN:	1569-1993, 1873-5010
Online Access:	Get full text
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