Cortical GABAergic Dysfunction in Stress and Depression: New Insights for Therapeutic Interventions

Major depressive disorder (MDD) is a debilitating illness characterized by neuroanatomical and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be precipitated by exposure to chronic stress. For decades, the monoaminergic deficit hypothesis of depression pro...

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Bibliographic Details
Published in:	Frontiers in cellular neuroscience Vol. 13; p. 87
Main Authors:	Fogaça, Manoela V., Duman, Ronald S.
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Research Foundation 12.03.2019 Frontiers Media S.A
Subjects:	Antidepressants Brain architecture Clonal deletion depression Drug development Drugs Functional anatomy GABA Glutamatergic transmission Hypotheses Interneurons Mental depression Neuropeptides Neuroscience Neurosciences Neurotransmission Parvalbumin Prefrontal cortex Proteins Psychiatry Receptor mechanisms Somatostatin Stress Synaptic transmission Therapeutic applications γ-Aminobutyric acid A receptors γ-Aminobutyric acid B receptors γ-Aminobutyric acid receptors United States > US stress ketamine parvalbumin prefrontal cortex somatostatin GABA depression
ISSN:	1662-5102, 1662-5102
Online Access:	Get full text
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