Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance

Progesterone-receptor membrane component 1 (PGRMC1/Sigma-2 receptor) is a haem-containing protein that interacts with epidermal growth factor receptor (EGFR) and cytochromes P450 to regulate cancer proliferation and chemoresistance; its structural basis remains unknown. Here crystallographic analyse...

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Bibliographic Details
Published in:	Nature communications Vol. 7; no. 1; pp. 11030 - 13
Main Authors:	Kabe, Yasuaki, Nakane, Takanori, Koike, Ikko, Yamamoto, Tatsuya, Sugiura, Yuki, Harada, Erisa, Sugase, Kenji, Shimamura, Tatsuro, Ohmura, Mitsuyo, Muraoka, Kazumi, Yamamoto, Ayumi, Uchida, Takeshi, Iwata, So, Yamaguchi, Yuki, Krayukhina, Elena, Noda, Masanori, Handa, Hiroshi, Ishimori, Koichiro, Uchiyama, Susumu, Kobayashi, Takuya, Suematsu, Makoto
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 18.03.2016 Nature Publishing Group Nature Portfolio
Subjects:	631/45/612/1237 631/67/1059/2326 631/80/86 96/95 Carbon monoxide Carbon Monoxide - metabolism Cell Proliferation Crystallography, X-Ray Cytochrome P-450 Enzyme System - metabolism Drug Resistance, Neoplasm Heme - metabolism Humanities and Social Sciences Humans Membrane Proteins - metabolism Models, Biological multidisciplinary Neoplasms - metabolism Neoplasms - pathology Protein Binding Protein Multimerization Receptor, Epidermal Growth Factor - metabolism Receptors, Progesterone - metabolism Receptors, sigma - metabolism Science Science (multidisciplinary) Signal Transduction - drug effects Solutions
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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