Three Distinct Types of Microautophagy Based on Membrane Dynamics and Molecular Machineries

Microautophagy is originally defined as lysosomal (vacuolar) membrane dynamics to directly enwrap and transport cytosolic components into the lumen of the lytic organelle. Molecular details of microautophagy had remained unknown until genetic studies in yeast identified a set of proteins required fo...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:BioEssays Jg. 40; H. 6; S. e1800008 - n/a
Hauptverfasser: Oku, Masahide, Sakai, Yasuyoshi
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Wiley Subscription Services, Inc 01.06.2018
Schlagworte:
Animals
autophagy
Autophagy - physiology
Cytosol - physiology
Intracellular Membranes - physiology
lysosome
Lysosomes - physiology
macroautophagy
microautophagy
Molecular chains
Proteins
vacuole
vacuoles
Vacuoles - physiology
Yeast
yeasts
autophagy
vacuole
lysosome
macroautophagy
microautophagy
ISSN:0265-9247, 1521-1878, 1521-1878
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Microautophagy is originally defined as lysosomal (vacuolar) membrane dynamics to directly enwrap and transport cytosolic components into the lumen of the lytic organelle. Molecular details of microautophagy had remained unknown until genetic studies in yeast identified a set of proteins required for the process. Subsequent studies with other experimental model organisms resulted in a series of discoveries that accompanied an expansion of the definition of microautophagy to also encompass endosomal membrane dynamics. These findings, however, still impose puzzling, non‐integrated images as to the molecular mechanism of microautophagy. By reviewing recent studies on microautophagy in various experimental systems, we propose the classification of microautophagy into three types, as the basis for developing a comprehensive view of the process. Microautophagy represents intracellular transport pathways of cytosolic components including organelles into the lysosome (vacuole) through deformation of the lysosomal or endosomal membrane. A classification of microautophagy into three types based on the site and morphology of the membrane deformation is proposed, referring to molecular machineries elucidated to date for each type.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:0265-9247
1521-1878
1521-1878
DOI:10.1002/bies.201800008