Database searching and accounting of multiplexed precursor and product ion spectra from the data independent analysis of simple and complex peptide mixtures

A novel database search algorithm is presented for the qualitative identification of proteins over a wide dynamic range, both in simple and complex biological samples. The algorithm has been designed for the analysis of data originating from data independent acquisitions, whereby multiple precursor...

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Bibliographic Details
Published in:	Proteomics (Weinheim) Vol. 9; no. 6; pp. 1696 - 1719
Main Authors:	Li, Guo-Zhong, Vissers, Johannes P.C, Silva, Jeffrey C, Golick, Dan, Gorenstein, Marc V, Geromanos, Scott J
Format:	Journal Article
Language:	English
Published:	Weinheim Wiley-VCH Verlag 01.03.2009 WILEY‐VCH Verlag Wiley-VCH
Subjects:	Algorithms Amino Acid Sequence Analytical, structural and metabolic biochemistry Biological and medical sciences Complex Mixtures - analysis Data independent LC‐MS Database searching Databases, Protein Fundamental and applied biological sciences. Psychology Miscellaneous Molecular Sequence Data Molecular Weight Multiplexed LC‐MS Parallel LC‐MS Peptides - analysis Protein Processing, Post-Translational Proteins Proteins - chemistry Proteome - analysis ROC Curve Shotgun sequencing Time Factors Parallel LC-MS Data analysis Multiplexed LC-MS Peptides Data independent LC-MS Proteomics Database Database searching Sequencing Shotgun sequencing
ISSN:	1615-9853, 1615-9861, 1615-9861
Online Access:	Get full text
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