Striatal Overexpression of ΔJunD Resets L-DOPA-Induced Dyskinesia in a Primate Model of Parkinson Disease

Involuntary movements, or dyskinesia, represent a debilitating complication of dopamine replacement therapy for Parkinson disease (PD). The transcription factor ΔFosB accumulates in the denervated striatum and dimerizes primarily with JunD upon repeated L-3,4-dihydroxyphenylalanine (L-DOPA) administ...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Biological psychiatry (1969) Ročník 66; číslo 6; s. 554 - 561
Hlavní autoři:	Berton, Olivier, Guigoni, Céline, Li, Qin, Bioulac, Bernard H., Aubert, Incarnation, Gross, Christian E., DiLeone, Ralph J., Nestler, Eric J., Bezard, Erwan
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York, NY Elsevier Inc 2009 Elsevier
Témata:	AAV Adult and adolescent clinical studies Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases dyskinesia L-DOPA LID Medical sciences Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Organic mental disorders. Neuropsychology Parkinson disease Psychiatric/Mental Health Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry ΔFosB ΔJunD ΔFosB AAV LID L-DOPA Parkinson disease ΔJunD dyskinesia Agonist Central nervous system Gene overexpression Cognition Encephalon Involuntary movement Primates Degenerative disease Levodopa Neurological disorder Motricity Dyskinesia Nervous system diseases Basal ganglion Corpus striatum Antiparkinson agent Motor control Cerebral disorder Vertebrata Mammalia D2 Dopamine receptor Central nervous system disease Models Extrapyramidal syndrome
ISSN:	0006-3223, 1873-2402
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!