Hyperglycemia, diabetes and stroke: Focus on the cerebrovasculature

Acute ischemic stroke (AIS) results from the occlusion of an artery and causes vascular and neuronal damage, both of which affect the extent of ischemic injury and stroke outcome. Despite extensive efforts, there is only one effective treatment for AIS. Given that up to 40% of the AIS patients prese...

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Bibliographic Details
Published in:Vascular pharmacology Vol. 51; no. 1; pp. 44 - 49
Main Authors: Ergul, Adviye, Li, Weiguo, Elgebaly, Mostafa M., Bruno, Askiel, Fagan, Susan C.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.07.2009
Subjects:
Animals
Brain - blood supply
Brain - physiology
Brain Ischemia - physiopathology
Cardiovascular
Cerebrovascular Circulation - physiology
Diabetes
Diabetes Mellitus - physiopathology
Humans
Hyperglycemia
Hyperglycemia - complications
Hyperglycemia - physiopathology
Ischemia reperfusion injury
Stroke
Stroke - complications
Stroke - physiopathology
Stroke
Hyperglycemia
Diabetes
Ischemia reperfusion injury
ISSN:1537-1891, 1879-3649, 1879-3649
Online Access:Get full text
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Summary:Acute ischemic stroke (AIS) results from the occlusion of an artery and causes vascular and neuronal damage, both of which affect the extent of ischemic injury and stroke outcome. Despite extensive efforts, there is only one effective treatment for AIS. Given that up to 40% of the AIS patients present with admission hyperglycemia either as a result of diabetes or acute stress response, targets for neuronal and vascular protection under hyperglycemic conditions need to be better defined. Here, we review the impact of diabetes and acute hyperglycemia on experimental stroke with an emphasis on cerebrovasculature structure and function. The relevance to clinical evidence is also discussed.
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ISSN:1537-1891
1879-3649
1879-3649
DOI:10.1016/j.vph.2009.02.004