Resveratrol for cancer therapy: Challenges and future perspectives

Resveratrol (3,4’,5-trihydroxy-trans-stilbene) has been expected to ameliorate cancer and foster breakthroughs in cancer therapy. Despite thousands of preclinical studies on the anticancer activity of resveratrol, little progress has been made in translational research and clinical trials. Most stud...

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Vydané v:	Cancer letters Ročník 515; s. 63 - 72
Hlavní autori:	Ren, Boxu, Kwah, Marabeth Xin-Yi, Liu, Cuiliu, Ma, Zhaowu, Shanmugam, Muthu K., Ding, Lingwen, Xiang, Xiaoqiang, Ho, Paul Chi-Lui, Wang, Lingzhi, Ong, Pei Shi, Goh, Boon Cher
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Ireland Elsevier B.V 01.09.2021 Elsevier Limited
Predmet:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antitumor activity Antitumor agents Bioavailability Biomarkers Cancer Cancer therapies Cancer treatment Chemotherapy Clinical trials Colorectal cancer Cytotoxicity Functional foods & nutraceuticals Humans Insulin Insulin-like growth factors Multiple myeloma Neoplasms - drug therapy Pharmacodynamics Pharmacokinetics Plasma Proteins Resveratrol Resveratrol - pharmacology Resveratrol - therapeutic use Signal transduction Signal Transduction - drug effects Skin Toxicity trans-Stilbene Tumor necrosis factor-TNF Tumorigenesis Cmax PGE2 Pharmacodynamics AST Cancer treatment Toxicity VEGF ALT IGF-1 Vd RASSF-1a MCP1 IGFBP-3 MPX TNF-α Resveratrol IC50 Tmax AMPK Pharmacokinetics Wnt
ISSN:	0304-3835, 1872-7980, 1872-7980
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Abstract	Resveratrol (3,4’,5-trihydroxy-trans-stilbene) has been expected to ameliorate cancer and foster breakthroughs in cancer therapy. Despite thousands of preclinical studies on the anticancer activity of resveratrol, little progress has been made in translational research and clinical trials. Most studies have focused on its anticancer effects, cellular mechanisms, and signal transduction pathways in vitro and in vivo. In this review, we aimed to discern the causes that prevent resveratrol from being used in cancer treatment. Among the various limitations, poor pharmacokinetics and low potency seem to be the two main bottlenecks of resveratrol. In addition, resveratrol-induced nephrotoxicity in multiple myeloma patients hinders its further development as an anticancer drug. New insights and strategies have been proposed to accelerate the conversion of resveratrol from bench to bedside. In the interim, the most promising approach is to enhance the bioavailability of resveratrol with new formulations. Alternatively, more potent analogues of resveratrol could be developed to augment its anticancer potency. Given all the gaps mentioned, much work remains to be done. However, if remarkable progress can be made, resveratrol may finally be used for cancer therapy. •Resveratrol attractive for treatment of colorectal and obesity-related cancers.•Poor bioavailability and low potency compromises anticancer activity of resveratrol.•Unconventional hermetic nature requires further investigation.
AbstractList	Resveratrol (3,4',5-trihydroxy-trans-stilbene) has been expected to ameliorate cancer and foster breakthroughs in cancer therapy. Despite thousands of preclinical studies on the anticancer activity of resveratrol, little progress has been made in translational research and clinical trials. Most studies have focused on its anticancer effects, cellular mechanisms, and signal transduction pathways in vitro and in vivo. In this review, we aimed to discern the causes that prevent resveratrol from being used in cancer treatment. Among the various limitations, poor pharmacokinetics and low potency seem to be the two main bottlenecks of resveratrol. In addition, resveratrol-induced nephrotoxicity in multiple myeloma patients hinders its further development as an anticancer drug. New insights and strategies have been proposed to accelerate the conversion of resveratrol from bench to bedside. In the interim, the most promising approach is to enhance the bioavailability of resveratrol with new formulations. Alternatively, more potent analogues of resveratrol could be developed to augment its anticancer potency. Given all the gaps mentioned, much work remains to be done. However, if remarkable progress can be made, resveratrol may finally be used for cancer therapy.Resveratrol (3,4',5-trihydroxy-trans-stilbene) has been expected to ameliorate cancer and foster breakthroughs in cancer therapy. Despite thousands of preclinical studies on the anticancer activity of resveratrol, little progress has been made in translational research and clinical trials. Most studies have focused on its anticancer effects, cellular mechanisms, and signal transduction pathways in vitro and in vivo. In this review, we aimed to discern the causes that prevent resveratrol from being used in cancer treatment. Among the various limitations, poor pharmacokinetics and low potency seem to be the two main bottlenecks of resveratrol. In addition, resveratrol-induced nephrotoxicity in multiple myeloma patients hinders its further development as an anticancer drug. New insights and strategies have been proposed to accelerate the conversion of resveratrol from bench to bedside. In the interim, the most promising approach is to enhance the bioavailability of resveratrol with new formulations. Alternatively, more potent analogues of resveratrol could be developed to augment its anticancer potency. Given all the gaps mentioned, much work remains to be done. However, if remarkable progress can be made, resveratrol may finally be used for cancer therapy. Resveratrol (3,4’,5-trihydroxy-trans-stilbene) has been expected to ameliorate cancer and foster breakthroughs in cancer therapy. Despite thousands of preclinical studies on the anticancer activity of resveratrol, little progress has been made in translational research and clinical trials. Most studies have focused on its anticancer effects, cellular mechanisms, and signal transduction pathways in vitro and in vivo. In this review, we aimed to discern the causes that prevent resveratrol from being used in cancer treatment. Among the various limitations, poor pharmacokinetics and low potency seem to be the two main bottlenecks of resveratrol. In addition, resveratrol-induced nephrotoxicity in multiple myeloma patients hinders its further development as an anticancer drug. New insights and strategies have been proposed to accelerate the conversion of resveratrol from bench to bedside. In the interim, the most promising approach is to enhance the bioavailability of resveratrol with new formulations. Alternatively, more potent analogues of resveratrol could be developed to augment its anticancer potency. Given all the gaps mentioned, much work remains to be done. However, if remarkable progress can be made, resveratrol may finally be used for cancer therapy. Resveratrol (3,4’,5-trihydroxy-trans-stilbene) has been expected to ameliorate cancer and foster breakthroughs in cancer therapy. Despite thousands of preclinical studies on the anticancer activity of resveratrol, little progress has been made in translational research and clinical trials. Most studies have focused on its anticancer effects, cellular mechanisms, and signal transduction pathways in vitro and in vivo. In this review, we aimed to discern the causes that prevent resveratrol from being used in cancer treatment. Among the various limitations, poor pharmacokinetics and low potency seem to be the two main bottlenecks of resveratrol. In addition, resveratrol-induced nephrotoxicity in multiple myeloma patients hinders its further development as an anticancer drug. New insights and strategies have been proposed to accelerate the conversion of resveratrol from bench to bedside. In the interim, the most promising approach is to enhance the bioavailability of resveratrol with new formulations. Alternatively, more potent analogues of resveratrol could be developed to augment its anticancer potency. Given all the gaps mentioned, much work remains to be done. However, if remarkable progress can be made, resveratrol may finally be used for cancer therapy. •Resveratrol attractive for treatment of colorectal and obesity-related cancers.•Poor bioavailability and low potency compromises anticancer activity of resveratrol.•Unconventional hermetic nature requires further investigation.
Author	Liu, Cuiliu Ding, Lingwen Ong, Pei Shi Kwah, Marabeth Xin-Yi Xiang, Xiaoqiang Shanmugam, Muthu K. Wang, Lingzhi Ma, Zhaowu Ho, Paul Chi-Lui Ren, Boxu Goh, Boon Cher
Author_xml	– sequence: 1 givenname: Boxu surname: Ren fullname: Ren, Boxu organization: School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, 434023, China – sequence: 2 givenname: Marabeth Xin-Yi surname: Kwah fullname: Kwah, Marabeth Xin-Yi organization: Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, 117543, Singapore – sequence: 3 givenname: Cuiliu surname: Liu fullname: Liu, Cuiliu organization: School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, 434023, China – sequence: 4 givenname: Zhaowu surname: Ma fullname: Ma, Zhaowu organization: School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, 434023, China – sequence: 5 givenname: Muthu K. surname: Shanmugam fullname: Shanmugam, Muthu K. organization: Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore – sequence: 6 givenname: Lingwen surname: Ding fullname: Ding, Lingwen organization: Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore – sequence: 7 givenname: Xiaoqiang orcidid: 0000-0002-8683-2603 surname: Xiang fullname: Xiang, Xiaoqiang organization: Department of Clinical Pharmacy, School of Pharmacy, Fudan University, Shanghai, 201203, China – sequence: 8 givenname: Paul Chi-Lui surname: Ho fullname: Ho, Paul Chi-Lui organization: Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, 117543, Singapore – sequence: 9 givenname: Lingzhi surname: Wang fullname: Wang, Lingzhi email: csiwl@nus.edu.sg organization: Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore – sequence: 10 givenname: Pei Shi surname: Ong fullname: Ong, Pei Shi email: phaops@nus.edu.sg organization: Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, 117543, Singapore – sequence: 11 givenname: Boon Cher surname: Goh fullname: Goh, Boon Cher email: phcgbc@nus.edu.sg organization: Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/34052324$$D View this record in MEDLINE/PubMed
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Snippet	Resveratrol (3,4’,5-trihydroxy-trans-stilbene) has been expected to ameliorate cancer and foster breakthroughs in cancer therapy. Despite thousands of... Resveratrol (3,4',5-trihydroxy-trans-stilbene) has been expected to ameliorate cancer and foster breakthroughs in cancer therapy. Despite thousands of...
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SubjectTerms	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antitumor activity Antitumor agents Bioavailability Biomarkers Cancer Cancer therapies Cancer treatment Chemotherapy Clinical trials Colorectal cancer Cytotoxicity Functional foods & nutraceuticals Humans Insulin Insulin-like growth factors Multiple myeloma Neoplasms - drug therapy Pharmacodynamics Pharmacokinetics Plasma Proteins Resveratrol Resveratrol - pharmacology Resveratrol - therapeutic use Signal transduction Signal Transduction - drug effects Skin Toxicity trans-Stilbene Tumor necrosis factor-TNF Tumorigenesis
Title	Resveratrol for cancer therapy: Challenges and future perspectives
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