Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase

The T-cell costimulatory receptors, CD28 and the inducible costimulator (ICOS), are required for the generation of follicular B helper T cells (T(FH)) and germinal center (GC) reaction. A common signal transducer used by CD28 and ICOS is the phosphoinositide 3-kinase (PI3K). Although it is known tha...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 106; no. 48; p. 20371
Main Authors:	Gigoux, Mathieu, Shang, Jijun, Pak, Youngshil, Xu, Minghong, Choe, Jongseon, Mak, Tak W, Suh, Woong-Kyung
Format:	Journal Article
Language:	English
Published:	United States 01.12.2009
Subjects:	Animals Antigens, Differentiation, T-Lymphocyte - immunology Antigens, Differentiation, T-Lymphocyte - metabolism CD28 Antigens - immunology CD28 Antigens - metabolism CD4-Positive T-Lymphocytes - metabolism Cell Differentiation - immunology Enzyme-Linked Immunosorbent Assay Immunoprecipitation Inducible T-Cell Co-Stimulator Protein Interleukin-4 - immunology Interleukins - immunology Mice Mice, Transgenic Phosphatidylinositol 3-Kinases - immunology Phosphatidylinositol 3-Kinases - metabolism Signal Transduction - immunology T-Lymphocytes, Helper-Inducer - immunology
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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