p16 Immunohistochemical Expression as a Surrogate Assessment of CDKN2A Alteration in Gliomas Leading to Prognostic Significances

CDKN2A is a tumor suppressor gene encoding the p16 protein, a key regulator of the cell cycle. CDKN2A homozygous deletion is a central prognostic factor for numerous tumors and can be detected by several techniques. This study aims to evaluate the extent to which immunohistochemical levels of p16 ex...

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Veröffentlicht in:	Cancers Jg. 15; H. 5; S. 1512
Hauptverfasser:	Geyer, Lucas, Wolf, Thibaut, Chenard, Marie-Pierre, Cebula, Helene, Schott, Roland, Noel, Georges, Guerin, Eric, Pencreach, Erwan, Reita, Damien, Entz-Werlé, Natacha, Lhermitte, Benoît
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland MDPI AG 28.02.2023 MDPI
Schlagworte:	Antibodies Biopsy Brain cancer Brain tumors Cancer Cell cycle Central nervous system Classification Clonal deletion Cloning Cyclin-dependent kinases Fluorescence in situ hybridization Gene deletion Gene expression Gene mutations Genetic aspects Glioma Gliomas Immunohistochemistry Kinases MAP kinase Medical prognosis Methods Nervous system Oncology, Experimental p16 Protein Patients Pediatrics Phase transitions Prognosis Proteins Tumor proteins Tumor suppressor genes Tumors Variables France FISH immunohistochemistry p16 gliomas prognosis CDKN2A deletion
ISSN:	2072-6694, 2072-6694
Online-Zugang:	Volltext
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