Benchmarking of Nanopore R10.4 and R9.4.1 flow cells in single-cell whole-genome amplification and whole-genome shotgun sequencing

Third-generation sequencing can be used in human cancer genomics and epigenomic research. Oxford Nanopore Technologies (ONT) recently released R10.4 flow cell, which claimed an improved read accuracy compared to R9.4.1 flow cell. To evaluate the benefits and defects of R10.4 flow cell for cancer cel...

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Veröffentlicht in:	Computational and structural biotechnology journal Jg. 21; S. 2352 - 2364
Hauptverfasser:	Ni, Ying, Liu, Xudong, Simeneh, Zemenu Mengistie, Yang, Mengsu, Li, Runsheng
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 01.01.2023 Research Network of Computational and Structural Biotechnology Elsevier
Schlagworte:	biotechnology cell lines epigenome genomics humans Long read Methylation Nanopore DNA sequencing nanopores neoplasm cells Single-cell whole genome amplification sequencing Whole genome shotgun sequencing WGS scWGA SV NSCLC Long read CNV MDA MALBAC Nanopore DNA sequencing Whole genome shotgun sequencing Single-cell whole genome amplification sequencing ONT FDR SNV NGS Methylation
ISSN:	2001-0370, 2001-0370
Online-Zugang:	Volltext
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