Reduced diversity in the early fecal microbiota of infants with atopic eczema
It might be that early intestinal colonization by bacteria in westernized infants fails to give rise to sufficient immune stimulation to support maturation of regulatory immune mechanisms. The purpose of the present study was to characterize the very early infantile microbiota by using a culture-ind...
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| Veröffentlicht in: | Journal of allergy and clinical immunology Jg. 121; H. 1; S. 129 - 134 |
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| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
New York, NY
Mosby, Inc
2008
Elsevier Elsevier Limited |
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| ISSN: | 0091-6749, 1097-6825, 1097-6825 |
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| Abstract | It might be that early intestinal colonization by bacteria in westernized infants fails to give rise to sufficient immune stimulation to support maturation of regulatory immune mechanisms.
The purpose of the present study was to characterize the very early infantile microbiota by using a culture-independent approach and to relate the colonization pattern to development of atopic eczema in the first 18 months of life.
Fecal samples were collected from 35 infants at 1 week of age. Twenty infants were healthy, and 15 infants were given diagnoses of atopic eczema at the age of 18 months. The fecal microbiota of the infants was compared by means of terminal restriction fragment length polymorphism (T-RFLP) and temporal temperature gradient gel electrophoresis (TTGE) analysis of amplified 16S rRNA genes.
By means of T-RFLP analysis, the median number of peaks, Shannon-Wiener index, and Simpson index of diversity were significantly less for infants with atopic eczema than for infants remaining healthy in the whole group and for the Swedish infants when
AluI was used for digestion. The same was found when TTGE patterns were compared. In addition, TTGE analysis showed significantly less bands and lower diversity indices for the British atopic infants compared with those of the control subjects.
There is a reduced diversity in the early fecal microbiota of infants with atopic eczema during the first 18 months of life. |
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| AbstractList | Background It might be that early intestinal colonization by bacteria in westernized infants fails to give rise to sufficient immune stimulation to support maturation of regulatory immune mechanisms. Objective The purpose of the present study was to characterize the very early infantile microbiota by using a culture-independent approach and to relate the colonization pattern to development of atopic eczema in the first 18 months of life. Methods Fecal samples were collected from 35 infants at 1 week of age. Twenty infants were healthy, and 15 infants were given diagnoses of atopic eczema at the age of 18 months. The fecal microbiota of the infants was compared by means of terminal restriction fragment length polymorphism (T-RFLP) and temporal temperature gradient gel electrophoresis (TTGE) analysis of amplified 16S rRNA genes. Results By means of T-RFLP analysis, the median number of peaks, Shannon-Wiener index, and Simpson index of diversity were significantly less for infants with atopic eczema than for infants remaining healthy in the whole group and for the Swedish infants whenAluI was used for digestion. The same was found when TTGE patterns were compared. In addition, TTGE analysis showed significantly less bands and lower diversity indices for the British atopic infants compared with those of the control subjects. Conclusion There is a reduced diversity in the early fecal microbiota of infants with atopic eczema during the first 18 months of life. BACKGROUND: It might be that early intestinal colonization by bacteria in westernized infants fails to give rise to sufficient immune stimulation to support maturation of regulatory immune mechanisms. OBJECTIVE: The purpose of the present study was to characterize the very early infantile microbiota by using a culture-independent approach and to relate the colonization pattern to development of atopic eczema in the first 18 months of life. METHODS: Fecal samples were collected from 35 infants at 1 week of age. Twenty infants were healthy, and 15 infants were given diagnoses of atopic eczema at the age of 18 months. The fecal microbiota of the infants was compared by means of terminal restriction fragment length polymorphism (T-RFLP) and temporal temperature gradient gel electrophoresis (TTGE) analysis of amplified 16S rRNA genes. RESULTS: By means of T-RFLP analysis, the median number of peaks, Shannon-Wiener index, and Simpson index of diversity were significantly less for infants with atopic eczema than for infants remaining healthy in the whole group and for the Swedish infants when AluI was used for digestion. The same was found when TTGE patterns were compared. In addition, TTGE analysis showed significantly less bands and lower diversity indices for the British atopic infants compared with those of the control subjects. CONCLUSION: There is a reduced diversity in the early fecal microbiota of infants with atopic eczema during the first 18 months of life. It might be that early intestinal colonization by bacteria in westernized infants fails to give rise to sufficient immune stimulation to support maturation of regulatory immune mechanisms. The purpose of the present study was to characterize the very early infantile microbiota by using a culture-independent approach and to relate the colonization pattern to development of atopic eczema in the first 18 months of life. Fecal samples were collected from 35 infants at 1 week of age. Twenty infants were healthy, and 15 infants were given diagnoses of atopic eczema at the age of 18 months. The fecal microbiota of the infants was compared by means of terminal restriction fragment length polymorphism (T-RFLP) and temporal temperature gradient gel electrophoresis (TTGE) analysis of amplified 16S rRNA genes. By means of T-RFLP analysis, the median number of peaks, Shannon-Wiener index, and Simpson index of diversity were significantly less for infants with atopic eczema than for infants remaining healthy in the whole group and for the Swedish infants when AluI was used for digestion. The same was found when TTGE patterns were compared. In addition, TTGE analysis showed significantly less bands and lower diversity indices for the British atopic infants compared with those of the control subjects. There is a reduced diversity in the early fecal microbiota of infants with atopic eczema during the first 18 months of life. Background It might be that early intestinal colonization by bacteria in westernized infants fails to give rise to sufficient immune stimulation to support maturation of regulatory immune mechanisms. Objective The purpose of the present study was to characterize the very early infantile microbiota by using a culture-independent approach and to relate the colonization pattern to development of atopic eczema in the first 18 months of life. Methods Fecal samples were collected from 35 infants at 1 week of age. Twenty infants were healthy, and 15 infants were given diagnoses of atopic eczema at the age of 18 months. The fecal microbiota of the infants was compared by means of terminal restriction fragment length polymorphism (T-RFLP) and temporal temperature gradient gel electrophoresis (TTGE) analysis of amplified 16S rRNA genes. Results By means of T-RFLP analysis, the median number of peaks, Shannon-Wiener index, and Simpson index of diversity were significantly less for infants with atopic eczema than for infants remaining healthy in the whole group and for the Swedish infants when Alu I was used for digestion. The same was found when TTGE patterns were compared. In addition, TTGE analysis showed significantly less bands and lower diversity indices for the British atopic infants compared with those of the control subjects. Conclusion There is a reduced diversity in the early fecal microbiota of infants with atopic eczema during the first 18 months of life. It might be that early intestinal colonization by bacteria in westernized infants fails to give rise to sufficient immune stimulation to support maturation of regulatory immune mechanisms. The purpose of the present study was to characterize the very early infantile microbiota by using a culture-independent approach and to relate the colonization pattern to development of atopic eczema in the first 18 months of life. Fecal samples were collected from 35 infants at 1 week of age. Twenty infants were healthy, and 15 infants were given diagnoses of atopic eczema at the age of 18 months. The fecal microbiota of the infants was compared by means of terminal restriction fragment length polymorphism (T-RFLP) and temporal temperature gradient gel electrophoresis (TTGE) analysis of amplified 16S rRNA genes. By means of T-RFLP analysis, the median number of peaks, Shannon-Wiener index, and Simpson index of diversity were significantly less for infants with atopic eczema than for infants remaining healthy in the whole group and for the Swedish infants when AluI was used for digestion. The same was found when TTGE patterns were compared. In addition, TTGE analysis showed significantly less bands and lower diversity indices for the British atopic infants compared with those of the control subjects. There is a reduced diversity in the early fecal microbiota of infants with atopic eczema during the first 18 months of life. It might be that early intestinal colonization by bacteria in westernized infants fails to give rise to sufficient immune stimulation to support maturation of regulatory immune mechanisms.BACKGROUNDIt might be that early intestinal colonization by bacteria in westernized infants fails to give rise to sufficient immune stimulation to support maturation of regulatory immune mechanisms.The purpose of the present study was to characterize the very early infantile microbiota by using a culture-independent approach and to relate the colonization pattern to development of atopic eczema in the first 18 months of life.OBJECTIVEThe purpose of the present study was to characterize the very early infantile microbiota by using a culture-independent approach and to relate the colonization pattern to development of atopic eczema in the first 18 months of life.Fecal samples were collected from 35 infants at 1 week of age. Twenty infants were healthy, and 15 infants were given diagnoses of atopic eczema at the age of 18 months. The fecal microbiota of the infants was compared by means of terminal restriction fragment length polymorphism (T-RFLP) and temporal temperature gradient gel electrophoresis (TTGE) analysis of amplified 16S rRNA genes.METHODSFecal samples were collected from 35 infants at 1 week of age. Twenty infants were healthy, and 15 infants were given diagnoses of atopic eczema at the age of 18 months. The fecal microbiota of the infants was compared by means of terminal restriction fragment length polymorphism (T-RFLP) and temporal temperature gradient gel electrophoresis (TTGE) analysis of amplified 16S rRNA genes.By means of T-RFLP analysis, the median number of peaks, Shannon-Wiener index, and Simpson index of diversity were significantly less for infants with atopic eczema than for infants remaining healthy in the whole group and for the Swedish infants when AluI was used for digestion. The same was found when TTGE patterns were compared. In addition, TTGE analysis showed significantly less bands and lower diversity indices for the British atopic infants compared with those of the control subjects.RESULTSBy means of T-RFLP analysis, the median number of peaks, Shannon-Wiener index, and Simpson index of diversity were significantly less for infants with atopic eczema than for infants remaining healthy in the whole group and for the Swedish infants when AluI was used for digestion. The same was found when TTGE patterns were compared. In addition, TTGE analysis showed significantly less bands and lower diversity indices for the British atopic infants compared with those of the control subjects.There is a reduced diversity in the early fecal microbiota of infants with atopic eczema during the first 18 months of life.CONCLUSIONThere is a reduced diversity in the early fecal microbiota of infants with atopic eczema during the first 18 months of life. |
| Author | Olsson, Crister Tripodi, Salvatore Molin, Göran Saalman, Robert Perkin, Michael R. Adlerberth, Ingegerd Karlsson, Caroline Martricardi, Paolo M. Coates, Anthony R. Åberg, Nils Wang, Mei Wold, Agnes E. Strachan, David P. Hesselmar, Bill Ahrné, Siv |
| Author_xml | – sequence: 1 givenname: Mei surname: Wang fullname: Wang, Mei organization: Department of Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden – sequence: 2 givenname: Caroline surname: Karlsson fullname: Karlsson, Caroline organization: Department of Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden – sequence: 3 givenname: Crister surname: Olsson fullname: Olsson, Crister organization: Department of Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden – sequence: 4 givenname: Ingegerd surname: Adlerberth fullname: Adlerberth, Ingegerd organization: Department of Clinical Bacteriology, Göteborg University, Göteborg, Sweden – sequence: 5 givenname: Agnes E. surname: Wold fullname: Wold, Agnes E. organization: Department of Clinical Bacteriology, Göteborg University, Göteborg, Sweden – sequence: 6 givenname: David P. surname: Strachan fullname: Strachan, David P. organization: Division of Community Health Sciences, St George's, University of London, London, United Kingdom – sequence: 7 givenname: Paolo M. surname: Martricardi fullname: Martricardi, Paolo M. organization: Department of Pediatric Pneumology and Immunology, Charité Medical University, Berlin, Germany – sequence: 8 givenname: Nils surname: Åberg fullname: Åberg, Nils organization: Department of Paediatrics, Göteborg University, Göteborg, Sweden – sequence: 9 givenname: Michael R. surname: Perkin fullname: Perkin, Michael R. organization: Division of Community Health Sciences, St George's, University of London, London, United Kingdom – sequence: 10 givenname: Salvatore surname: Tripodi fullname: Tripodi, Salvatore organization: Pediatric Allergology Unit, Sandro Pertini Hospital, Rome, Italy – sequence: 11 givenname: Anthony R. surname: Coates fullname: Coates, Anthony R. organization: Medical Microbiology, Department of Cellular and Molecular Medicine, St George's, University of London, London, United Kingdom – sequence: 12 givenname: Bill surname: Hesselmar fullname: Hesselmar, Bill organization: Department of Paediatrics, Göteborg University, Göteborg, Sweden – sequence: 13 givenname: Robert surname: Saalman fullname: Saalman, Robert organization: Department of Paediatrics, Göteborg University, Göteborg, Sweden – sequence: 14 givenname: Göran surname: Molin fullname: Molin, Göran organization: Department of Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden – sequence: 15 givenname: Siv surname: Ahrné fullname: Ahrné, Siv email: siv.ahrne@appliednutrition.lth.se organization: Department of Food Technology, Engineering and Nutrition, Lund University, Lund, Sweden |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20369655$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/18028995$$D View this record in MEDLINE/PubMed https://gup.ub.gu.se/publication/67597$$DView record from Swedish Publication Index (Göteborgs universitet) |
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| Keywords | intestinal microbiota diversity T-RFLP TTGE temporal temperature gradient gel electrophoresis T-RF terminal restriction fragment length polymorphism Atopic eczema Cy5 Terminal restriction fragment Indodicarbocyanine Human Allergy Immunopathology Skin disease Gradient Temperature Digestive system Gel electrophoresis Gut Infant Atopy Immunology Restriction fragment length polymorphism Eczema Genetics Early Feces Molecular biology |
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| Snippet | It might be that early intestinal colonization by bacteria in westernized infants fails to give rise to sufficient immune stimulation to support maturation of... Background It might be that early intestinal colonization by bacteria in westernized infants fails to give rise to sufficient immune stimulation to support... BACKGROUND: It might be that early intestinal colonization by bacteria in westernized infants fails to give rise to sufficient immune stimulation to support... |
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| SubjectTerms | Age Allergic diseases Allergies Allergy and Immunology Antibiotics Asthma Atopic eczema Bacteria Bacteria - classification Bacteria - genetics Bacteria - isolation & purification Biological and medical sciences Deoxyribonucleic acid Dermatitis, Atopic - immunology Dermatitis, Atopic - microbiology diversity DNA DNA, Bacterial - analysis DNA, Bacterial - isolation & purification Eczema Electrophoresis, Agar Gel Feces - microbiology Fundamental and applied biological sciences. Psychology Fundamental immunology Genetic Variation Humans Hypotheses Immunologi inom det medicinska området Immunology in the Medical Area Immunopathology Infant Infant, Newborn intestinal microbiota Medical sciences Nutrition research Polymorphism, Restriction Fragment Length RNA, Ribosomal, 16S - genetics Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Skin allergic diseases. Stinging insect allergies temporal temperature gradient gel electrophoresis terminal restriction fragment length polymorphism |
| Title | Reduced diversity in the early fecal microbiota of infants with atopic eczema |
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