Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis

Multiple signatures of somatic mutations have been identified in cancer genomes. Exome sequences of 1,001 human cancer cell lines and 577 xenografts revealed most common mutational signatures, indicating past activity of the underlying processes, usually in appropriate cancer types. To investigate o...

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Bibliographic Details
Published in:	Cell Vol. 176; no. 6; p. 1282
Main Authors:	Petljak, Mia, Alexandrov, Ludmil B, Brammeld, Jonathan S, Price, Stacey, Wedge, David C, Grossmann, Sebastian, Dawson, Kevin J, Ju, Young Seok, Iorio, Francesco, Tubio, Jose M C, Koh, Ching Chiek, Georgakopoulos-Soares, Ilias, Rodríguez-Martín, Bernardo, Otlu, Burçak, O'Meara, Sarah, Butler, Adam P, Menzies, Andrew, Bhosle, Shriram G, Raine, Keiran, Jones, David R, Teague, Jon W, Beal, Kathryn, Latimer, Calli, O'Neill, Laura, Zamora, Jorge, Anderson, Elizabeth, Patel, Nikita, Maddison, Mark, Ng, Bee Ling, Graham, Jennifer, Garnett, Mathew J, McDermott, Ultan, Nik-Zainal, Serena, Campbell, Peter J, Stratton, Michael R
Format:	Journal Article
Language:	English
Published:	United States 07.03.2019
Subjects:	APOBEC Deaminases - genetics APOBEC Deaminases - metabolism Cell Line Cell Line, Tumor Databases, Genetic DNA - metabolism DNA Mutational Analysis - methods Exome Genome, Human - genetics Heterografts Humans Mutagenesis Mutation - genetics Mutation Rate Neoplasms - genetics Retroelements Whole Exome Sequencing - methods APOBEC deaminases cancer cell lines episodic mutagenesis xenografts mutational signatures
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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