Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis

Multiple signatures of somatic mutations have been identified in cancer genomes. Exome sequences of 1,001 human cancer cell lines and 577 xenografts revealed most common mutational signatures, indicating past activity of the underlying processes, usually in appropriate cancer types. To investigate o...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell Jg. 176; H. 6; S. 1282
Hauptverfasser:	Petljak, Mia, Alexandrov, Ludmil B, Brammeld, Jonathan S, Price, Stacey, Wedge, David C, Grossmann, Sebastian, Dawson, Kevin J, Ju, Young Seok, Iorio, Francesco, Tubio, Jose M C, Koh, Ching Chiek, Georgakopoulos-Soares, Ilias, Rodríguez-Martín, Bernardo, Otlu, Burçak, O'Meara, Sarah, Butler, Adam P, Menzies, Andrew, Bhosle, Shriram G, Raine, Keiran, Jones, David R, Teague, Jon W, Beal, Kathryn, Latimer, Calli, O'Neill, Laura, Zamora, Jorge, Anderson, Elizabeth, Patel, Nikita, Maddison, Mark, Ng, Bee Ling, Graham, Jennifer, Garnett, Mathew J, McDermott, Ultan, Nik-Zainal, Serena, Campbell, Peter J, Stratton, Michael R
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 07.03.2019
Schlagworte:	APOBEC Deaminases - genetics APOBEC Deaminases - metabolism Cell Line Cell Line, Tumor Databases, Genetic DNA - metabolism DNA Mutational Analysis - methods Exome Genome, Human - genetics Heterografts Humans Mutagenesis Mutation - genetics Mutation Rate Neoplasms - genetics Retroelements Whole Exome Sequencing - methods APOBEC deaminases cancer cell lines episodic mutagenesis xenografts mutational signatures
ISSN:	1097-4172, 1097-4172
Online-Zugang:	Weitere Angaben
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!