A key role for NOX4 in epithelial cell death during development of lung fibrosis

The pathogenesis of pulmonary fibrosis is linked to oxidative stress, possibly generated by the reactive oxygen species (ROS) generating NADPH oxidase NOX4. Epithelial cell death is a crucial early step in the development of the disease, followed only later by the fibrotic stage. We demonstrate that...

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Vydáno v:	Antioxidants & redox signaling Ročník 15; číslo 3; s. 607
Hlavní autoři:	Carnesecchi, Stephanie, Deffert, Christine, Donati, Yves, Basset, Olivier, Hinz, Boris, Preynat-Seauve, Olivier, Guichard, Cecile, Arbiser, Jack L, Banfi, Botond, Pache, Jean-Claude, Barazzone-Argiroffo, Constance, Krause, Karl-Heinz
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.08.2011
Témata:	Animals Apoptosis - drug effects Apoptosis - genetics Bleomycin - pharmacology Cells, Cultured Gene Expression Idiopathic Pulmonary Fibrosis - genetics Idiopathic Pulmonary Fibrosis - metabolism Idiopathic Pulmonary Fibrosis - pathology Male Mice NADPH Oxidase 4 NADPH Oxidases - antagonists & inhibitors NADPH Oxidases - genetics NADPH Oxidases - metabolism Oxidative Stress - genetics Pulmonary Alveoli - drug effects Pulmonary Alveoli - metabolism Pulmonary Alveoli - pathology Reactive Oxygen Species - metabolism Respiratory Mucosa - metabolism Respiratory Mucosa - pathology RNA, Small Interfering - genetics Smad2 Protein - metabolism Transforming Growth Factor beta1 - metabolism
ISSN:	1557-7716, 1557-7716
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