In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies

SARS-CoV-2-neutralizing antibodies (NAbs) protect against COVID-19. A concern regarding SARS-CoV-2 antibodies is whether they mediate disease enhancement. Here, we isolated NAbs against the receptor-binding domain (RBD) or the N-terminal domain (NTD) of SARS-CoV-2 spike from individuals with acute o...

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Bibliographic Details
Published in:	Cell Vol. 184; no. 16; p. 4203
Main Authors:	Li, Dapeng, Edwards, Robert J, Manne, Kartik, Martinez, David R, Schäfer, Alexandra, Alam, S Munir, Wiehe, Kevin, Lu, Xiaozhi, Parks, Robert, Sutherland, Laura L, Oguin, 3rd, Thomas H, McDanal, Charlene, Perez, Lautaro G, Mansouri, Katayoun, Gobeil, Sophie M C, Janowska, Katarzyna, Stalls, Victoria, Kopp, Megan, Cai, Fangping, Lee, Esther, Foulger, Andrew, Hernandez, Giovanna E, Sanzone, Aja, Tilahun, Kedamawit, Jiang, Chuancang, Tse, Longping V, Bock, Kevin W, Minai, Mahnaz, Nagata, Bianca M, Cronin, Kenneth, Gee-Lai, Victoria, Deyton, Margaret, Barr, Maggie, Von Holle, Tarra, Macintyre, Andrew N, Stover, Erica, Feldman, Jared, Hauser, Blake M, Caradonna, Timothy M, Scobey, Trevor D, Rountree, Wes, Wang, Yunfei, Moody, M Anthony, Cain, Derek W, DeMarco, C Todd, Denny, Thomas N, Woods, Christopher W, Petzold, Elizabeth W, Schmidt, Aaron G, Teng, I-Ting, Zhou, Tongqing, Kwong, Peter D, Mascola, John R, Graham, Barney S, Moore, Ian N, Seder, Robert, Andersen, Hanne, Lewis, Mark G, Montefiori, David C, Sempowski, Gregory D, Baric, Ralph S, Acharya, Priyamvada, Haynes, Barton F, Saunders, Kevin O
Format:	Journal Article
Language:	English
Published:	United States 05.08.2021
Subjects:	Animals Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Bronchoalveolar Lavage Fluid - chemistry COVID-19 - pathology COVID-19 - virology Cytokines - metabolism Female Haplorhini Humans Lung - pathology Lung - virology Male Mice Mice, Inbred BALB C Protein Domains Receptors, IgG - metabolism SARS-CoV-2 - isolation & purification SARS-CoV-2 - physiology Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - immunology Viral Load Virus Replication COVID-19 electron micrograph SARS-CoV-2 cross-neutralization receptor-binding domain neutralizing antibody N-terminal domain antibody-dependent enhancement infection enhancement in vivo protection
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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