Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures

A single mouse blastomere from an embryo until the 8-cell stage can generate an entire blastocyst. Whether laboratory-cultured cells retain a similar generative capacity remains unknown. Starting from a single stem cell type, extended pluripotent stem (EPS) cells, we established a 3D differentiation...

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Veröffentlicht in:	Cell Jg. 179; H. 3; S. 687
Hauptverfasser:	Li, Ronghui, Zhong, Cuiqing, Yu, Yang, Liu, Haisong, Sakurai, Masahiro, Yu, Leqian, Min, Zheying, Shi, Lei, Wei, Yulei, Takahashi, Yuta, Liao, Hsin-Kai, Qiao, Jie, Deng, Hongkui, Nuñez-Delicado, Estrella, Rodriguez Esteban, Concepcion, Wu, Jun, Izpisua Belmonte, Juan Carlos
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 17.10.2019
Schlagworte:	Animals Blastocyst - cytology Blastocyst - metabolism Cell Differentiation Cell Line Cell Lineage Cells, Cultured Cellular Reprogramming Techniques - methods Embryo Implantation Female Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Male Mice Mice, Inbred C57BL Mice, Inbred ICR Mouse Embryonic Stem Cells - cytology Mouse Embryonic Stem Cells - metabolism Research Embryo Creation - methods Transcriptome blastoids reprogramming extended pluripotent stem cells EPS-blastoid implantation blastocyst EPS cells totipotent
ISSN:	1097-4172, 1097-4172
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