Somatic Evolution in Non-neoplastic IBD-Affected Colon

Inflammatory bowel disease (IBD) is a chronic inflammatory disease associated with increased risk of gastrointestinal cancers. We whole-genome sequenced 446 colonic crypts from 46 IBD patients and compared these to 412 crypts from 41 non-IBD controls from our previous publication on the mutation lan...

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Vydáno v:	Cell Ročník 182; číslo 3; s. 672
Hlavní autoři:	Olafsson, Sigurgeir, McIntyre, Rebecca E, Coorens, Tim, Butler, Timothy, Jung, Hyunchul, Robinson, Philip S, Lee-Six, Henry, Sanders, Mathijs A, Arestang, Kenneth, Dawson, Claire, Tripathi, Monika, Strongili, Konstantina, Hooks, Yvette, Stratton, Michael R, Parkes, Miles, Martincorena, Inigo, Raine, Tim, Campbell, Peter J, Anderson, Carl A
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 06.08.2020
Témata:	Adult Aged Aged, 80 and over Aging - genetics Clonal Evolution - genetics Clonal Evolution - immunology Colitis - genetics Colitis - metabolism Colitis, Ulcerative - genetics Colitis, Ulcerative - metabolism Crohn Disease - genetics Crohn Disease - metabolism DNA-Binding Proteins - genetics Epithelial Cells - metabolism Epithelial Cells - pathology F-Box-WD Repeat-Containing Protein 7 - genetics Female Humans INDEL Mutation Inflammatory Bowel Diseases - genetics Inflammatory Bowel Diseases - immunology Inflammatory Bowel Diseases - metabolism Inflammatory Bowel Diseases - pathology Interleukin-17 - metabolism Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Male Middle Aged Mutation Rate Phylogeny Point Mutation Receptors, Cell Surface - genetics Ribonucleases - genetics Toll-Like Receptors - genetics Transcription Factors - genetics Whole Genome Sequencing somatic mutations PIGR mutational signatures ZC3H12A Crohn's disease mutation rate ulcerative colitis IL17 intestinal epithelia inflammatory bowel disease
ISSN:	1097-4172, 1097-4172
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