Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1

Although many distinct mutations in a variety of genes are known to cause Amyotrophic Lateral Sclerosis (ALS), it remains poorly understood how they selectively impact motor neuron biology and whether they converge on common pathways to cause neuronal degeneration. Here, we have combined reprogrammi...

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Bibliographic Details

Published in:	Cell stem cell Vol. 14; no. 6; p. 781
Main Authors:	Kiskinis, Evangelos, Sandoe, Jackson, Williams, Luis A, Boulting, Gabriella L, Moccia, Rob, Wainger, Brian J, Han, Steve, Peng, Theodore, Thams, Sebastian, Mikkilineni, Shravani, Mellin, Cassidy, Merkle, Florian T, Davis-Dusenbery, Brandi N, Ziller, Michael, Oakley, Derek, Ichida, Justin, Di Costanzo, Stefania, Atwater, Nick, Maeder, Morgan L, Goodwin, Mathew J, Nemesh, James, Handsaker, Robert E, Paull, Daniel, Noggle, Scott, McCarroll, Steven A, Joung, J Keith, Woolf, Clifford J, Brown, Robert H, Eggan, Kevin
Format:	Journal Article
Language:	English
Published:	United States 05.06.2014
Subjects:	Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - pathology Humans Motor Neurons - metabolism Motor Neurons - pathology Mutation Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxide Dismutase-1
ISSN:	1875-9777, 1875-9777
Online Access:	Get more information
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