A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors

Using untargeted metabolomics (n = 1,162 subjects), the plasma metabolite (m/z = 265.1188) phenylacetylglutamine (PAGln) was discovered and then shown in an independent cohort (n = 4,000 subjects) to be associated with cardiovascular disease (CVD) and incident major adverse cardiovascular events (my...

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Bibliographic Details
Published in:	Cell Vol. 180; no. 5; p. 862
Main Authors:	Nemet, Ina, Saha, Prasenjit Prasad, Gupta, Nilaksh, Zhu, Weifei, Romano, Kymberleigh A, Skye, Sarah M, Cajka, Tomas, Mohan, Maradumane L, Li, Lin, Wu, Yuping, Funabashi, Masanori, Ramer-Tait, Amanda E, Naga Prasad, Sathyamangla Venkata, Fiehn, Oliver, Rey, Federico E, Tang, W H Wilson, Fischbach, Michael A, DiDonato, Joseph A, Hazen, Stanley L
Format:	Journal Article
Language:	English
Published:	United States 05.03.2020
Subjects:	Animals Arteries - injuries Arteries - metabolism Arteries - microbiology Bacterial Proteins - genetics Bacterial Proteins - metabolism Blood Platelets - metabolism Blood Platelets - microbiology Cardiovascular Diseases - blood Cardiovascular Diseases - genetics Cardiovascular Diseases - microbiology Cardiovascular Diseases - pathology Death, Sudden, Cardiac - pathology Gastrointestinal Microbiome - genetics Glutamine - analogs & derivatives Glutamine - blood Glutamine - genetics Humans Male Metabolome - genetics Metabolomics - methods Mice Myocardial Infarction - blood Myocardial Infarction - microbiology Platelet Activation - genetics Receptors, Adrenergic, alpha - blood Receptors, Adrenergic, alpha - genetics Receptors, Adrenergic, beta - blood Receptors, Adrenergic, beta - genetics Risk Factors Stroke - blood Stroke - microbiology Stroke - pathology Thrombosis - genetics Thrombosis - metabolism Thrombosis - microbiology Thrombosis - pathology cardiovascular disease GPCR thrombosis gut microbe metabolomics adrenergic receptors
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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